Results 91 to 100 of about 172,292 (284)

Synthesis and Antioxidant Activities of Novel Pyrimidine Acrylamides as Inhibitors of Lipoxygenase: Molecular Modeling and In Silico Physicochemical Studies

Molecules
The pyrimidine ring is present in various biomolecules such as DNA and RNA bases, aminoacids, vitamins, etc. Additionally, many clinically used drugs including methotrexate and risperidone contain the pyrimidine heterocyclic scaffold as well.
Michail Saragatsis, Eleni Pontiki
doaj   +1 more source

Synthesis of New Pyrazole and Pyrimidine Steroidal Derivatives

Molecules, 2003
The synthesis of steroidal heterocycles containing the pyrazole and pyrimidine ring fused to the 16,17-position of the steroid nucleus is reported. Androstenolone acetate (1) reacted with carbon disulfide, iodomethane and sodium hydride to furnish 3β ...
Francisco Coll, Reinaldo Molina, Alina Montero, Isabel Jomarrón, Klaus Peseke, Daniel G. Rivera   +5 more
doaj   +1 more source

Serendipitous Identification of Azine Anticancer Agents Using a Privileged Scaffold Morphing Strategy

Molecules
The use of privileged scaffolds as a starting point for the construction of libraries of bioactive compounds is a widely used strategy in drug discovery and development.
Silvia Cesarini, Ilaria Vicenti, Federica Poggialini, Silvia Filippi, Eleonora Mancin, Lia Fiaschi, Elisa De Marchi, Federica Giammarino, Chiara Vagaggini, Bruno Mattia Bizzarri, Raffaele Saladino, Elena Dreassi, Maurizio Zazzi, Lorenzo Botta   +13 more
doaj   +1 more source

The LANCA three-component reaction to highly substituted β-ketoenamides – versatile intermediates for the synthesis of functionalized pyridine, pyrimidine, oxazole and quinoxaline derivatives

Beilstein Journal of Organic Chemistry, 2019
The LANCA three-component reaction of lithiated alkoxyallenes LA, nitriles N and carboxylic acids CA leads to β-ketoenamides KE in good to excellent yields.
Tilman Lechel, Roopender Kumar, Mrinal K. Bera, Reinhold Zimmer, Hans-Ulrich Reissig   +4 more
doaj   +1 more source

The accumulation of orotic acid by a pyrimidineless mutant of Neurospora [PDF]

, 1948
The discovery of orotic acid (1,2-carboxyuracil) in cow's milk by Biscaro and Belloni (1), followed by its identification and synthesis (2-4), led to a number of speculations as to its biological origin and significance (,3,5,6).
Houlahan, Mary B., Mitchell, Herschel K., Nyc, Joseph F.   +2 more
core  

Nitrogen doping of carbon nanoelectrodes for enhanced control of DNA translocation dynamics

, 2017
Controlling the dynamics of DNA translocation is a central issue in the emerging nanopore-based DNA sequencing. To address the potential of heteroatom doping of carbon nanostructures to achieve this goal, herein we carry out atomistic molecular dynamics ...
Cho, Art E., Jung, Sang Won, Kim, Han Seul, Kim, Yong-Hoon   +3 more
core   +9 more sources

In Plane Vibration of Pyrimidine and some Deuterated Pyrimidines [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1991
On the basis of 102 assigned frequencies to in plane vibrations of pyrimidine, pyrimidine-2-d2, pyrimidine-2, 5-d2, pyrimidine-4,6-d2, pyrimidine-2,4,6-d3 and pyrimidine-d4, 35 valance force field constants including 14 principals and 21 interaction force constants are calculated.
openaire   +2 more sources

DNA viewed as an out-of-equilibrium structure

, 2013
The complexity of the primary structure of human DNA is explored using methods from nonequilibrium statistical mechanics, dynamical systems theory and information theory.
Nicolis, C., Nicolis, G., Provata, A.
core   +1 more source

RESEARCHES ON PYRIMIDINES: SYNTHESIS OF URACIL-4-ACETIC ACID. [PDF]

, 1908
Henry L. Wheeler, Leonard M. Liddle
openalex   +1 more source

Studies on the Physiology of Pyrimidines. The Metabolism of the Pyrimidine Nucleosides

Experimental Biology and Medicine, 1929
The results of previous work by one of us1 indicated that the pyrimidines uracil and thymine, when fed in small amounts to dogs, are to a large extent metabolized. In the case of cytosine it was found that this substance was not utilized. It was partly excreted unchanged, partly deaminized and excreted in the form of uracil.These experiments were ...
O. H. Emerson, L. R. Cerecedo
openaire   +2 more sources