Results 51 to 60 of about 172,292 (284)
Elevated Level of DNA Damage and Impaired Repair of Oxidative DNA Damage in Patients with Recurrent Depressive Disorder [PDF]
, 2015 Background: Depressive disorder (DD), including recurrent DD (rDD), is a severe psychological disease, which affects a large percentage of the world population.
Bielecka-Kowalska, Anna +9 more
core +1 more source
Deoxyribonucleotide Triphosphate Metabolism in Cancer and Metabolic Disease
Frontiers in Endocrinology, 2018 The maintenance of a healthy deoxyribonucleotide triphosphate (dNTP) pool is critical for the proper replication and repair of both nuclear and mitochondrial DNA.
Raquel Buj, Katherine M. Aird
doaj +1 more source
Synthesis of novel pyrimidine and fused pyrimidine derivatives [PDF]
European Journal of Chemistry, 2011 4-Amino-2-(benzylthio)-6-(4-methoxyphenyl)pyrimidine-5-carbonitrile ( 1 ) was prepared by treatment of s-benzylthiuronium chloride with 2-(4-methoxybenzylidene)malononitrile in ethanolic sodium hydroxide with hydrazine hydrate to afford the hydrazino derivative 2 , which was allowed to react with different electrophilic reagents to give the pyrimidine
Mahmoud R. Mahmoud +3 more
openaire +1 more source
REVIEW OF PYRIMIDINE DERIVATIVES AS PHARMACOLOGICALLY ACTIVE COMPOUNDS
Juvenis Scientia, 2022 Pyrimidine derivatives represent an extensive class of organic compounds that contain in their structure a six-membered heterocycle with two nitrogen atoms at positions 1 and 3.
A. S. Chiriapkin
doaj +1 more source
Molecules, 2021 Enterococcus faecalis is known as a significant nosocomial pathogen due to its natural resistance to many antibacterial drugs. Moreover, it was found that E. faecalis infection causes inflammation, production of reactive oxygen species, and DNA damage to
Marcin Stolarczyk +6 more
doaj +1 more source
Molecules, 2013 Herein we describe NMR experiments and structural modifications of 4-methyl-2-phenylpyrimidine-N-acylhydrazone compounds (aryl-NAH) in order to discover if duplication of some signals in their 1H- and 13C-NMR spectra was related to a mixture of imine ...
Alexandra Basilio Lopes +5 more
doaj +1 more source
The study of the apoptogenic effect of pyrimidine derivatives on murine leukemia cells [PDF]
Archive of Oncology, 2005 BACKGROUND: In the light of the recent findings concerning the role of apoptosis and of tumor cell enzymes in cancer chemotherapy, the interest in pyrimidine derivatives has greatly increased.
Gorneva Galina +3 more
doaj +1 more source
A New Class of Uracil–DNA Glycosylase Inhibitors Active against Human and Vaccinia Virus Enzyme
Molecules, 2021 Uracil–DNA glycosylases are enzymes that excise uracil bases appearing in DNA as a result of cytosine deamination or accidental dUMP incorporation from the dUTP pool. The activity of Family 1 uracil–DNA glycosylase (UNG) activity limits the efficiency of
Inga R. Grin +10 more
doaj +1 more source
Unusual Nucleophilic Addition of Grignard Reagents in the Synthesis of 4-Amino-pyrimidines [PDF]
, 2018 Pyrimidines have always received considerable attention because of their importance in synthesis and elucidation of biochemical roles, in particular that of vitamin B1.
Hughes, David L. +3 more
core +3 more sources
A search for interstellar pyrimidine [PDF]
Monthly Notices of the Royal Astronomical Society, 2003 8 pages, 5 figures, accepted for publication in ...
H. C. Huang +6 more
openaire +3 more sources