Results 61 to 70 of about 67,989 (334)
Deficiency of the purinergic receptor 2X7 attenuates nonalcoholic steatohepatitis induced by high-fat diet. possible role of the NLRP3 Inflammasome [PDF]
, 2017 Molecular mechanisms driving transition from simple steatosis to nonalcoholic steatohepatitis (NASH), a critical step in the progression of nonalcoholic fatty liver disease (NAFLD) to cirrhosis, are poorly defined. This study aimed at investigating the
Blasetti Fantauzzi, Claudia +6 more
core +3 more sources
Scientific Reports, 2023 In this study, we examined the impact of demyelinating and neuroinflammation on trigeminal neuralgia (TN) by utilizing models of chronic constriction injury to the infraorbital nerve (CCI).
Mingxing Liu +9 more
doaj +1 more source
iScience, 2023 Summary: Hepatocyte pyroptosis has been shown to be involved in liver damage progression. Previously, we found that growth arrest-specific 5 (GAS5) is a regulator of hepatic stellate cell (HSC) activation. However, whether GAS5 plays a role in hepatocyte
Zhichao Lang +10 more
doaj +1 more source
Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. [PDF]
, 2006 To restrict infection by Legionella pneumophila, mouse macrophages require Naip5, a member of the nucleotide-binding oligomerization domain leucine-rich repeat family of pattern recognition receptors, which detect cytoplasmic microbial products.
Byrne, Brenda G +6 more
core +2 more sources
Pyroptosis in spinal cord injury
Frontiers in Cellular Neuroscience, 2022 Spinal cord injury (SCI) often brings devastating consequences to patients and their families. Pathophysiologically, the primary insult causes irreversible damage to neurons and glial cells and initiates the secondary damage cascade, further leading to inflammation, ischemia, and cells death.
Jian Yin +4 more
openaire +3 more sources
Advanced NanoBiomed Research, 2023 Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two main reasons for the poor outcomes of tumor treatment. Pyroptosis is a newly discovered form of programmed cell death, featuring surprising proinflammatory activity ...
Yuan Ding +4 more
doaj +1 more source
Hyphal growth of phagocytosed fusarium oxysporum causes cell lysis and death of murine macrophages [PDF]
, 2014 Peer reviewedPublisher ...
Bain, Judith M +4 more
core +4 more sources
The regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases
Cell Death Discovery, 2022 Pyroptosis is a controlled form of inflammatory cell death characterized by inflammasome activation, pore formation, and cell lysis. According to different caspases, pyroptosis can be divided into canonical, non-canonical, and other pathways. The role of
Siyu Wang +6 more
doaj +1 more source
Frontiers in Genetics, 2022 Clear cell renal cell carcinoma (ccRCC) is a common urinary system malignant tumor with a high incidence and recurrence rate. Pyroptosis is a kind of programmed cell death caused by inflammasomes.
Ming Zhong +10 more
doaj +1 more source
Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease [PDF]
, 2017 Rabies virus is a highly neurovirulent RNA virus, which causes about 59000 deaths in humans each year. Previously, we described macrophage cytotoxicity upon infection with rabies virus.
Beyaert, Rudi +9 more
core +2 more sources