Results 61 to 70 of about 77,046 (386)
The role of pyroptosis in cognitive impairment
Frontiers in Neuroscience, 2023 Cognitive impairment is a major global disease, manifests as a decline in cognitive functioning and endangers the health of the population worldwide. The incidence of cognitive impairment has increased rapidly with an increasingly aging population.
Xin Yang, Zhe Tang
openaire +3 more sources
HMGB1 mediates lipopolysaccharide-induced macrophage autophagy and pyroptosis
BMC Molecular and Cell Biology, 2023 Autophagy and pyroptosis of macrophages play important protective or detrimental roles in sepsis. However, the underlying mechanisms remain unclear.
Jiawei Shang +5 more
doaj +1 more source
, 2018 In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation.
Sandstrom, Andrew, VANCE, Russell E.
core +1 more source
Oncolytic Parapoxvirus induces Gasdermin E-mediated pyroptosis and activates antitumor immunity
Nature Communications, 2023 Oncolytic viruses are able to target tumours and thought to induce apoptosis while remodelling the tumour immune microenvironment. Here authors show in an oncolytic parapoxvirus ovis model that pyroptosis, a highly immunogenic Gasdermin-E-dependent cell ...
Jing Lin +22 more
semanticscholar +1 more source
Advanced NanoBiomed Research, 2023 Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two main reasons for the poor outcomes of tumor treatment. Pyroptosis is a newly discovered form of programmed cell death, featuring surprising proinflammatory activity ...
Yuan Ding +4 more
doaj +1 more source
Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]
, 2011 Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle +3 more
core +2 more sources
Pyroptosis and inflammasomes in cancer and inflammation
MedComm, 2023 AbstractNonprogrammed cell death (NPCD) and programmed cell death (PCD) are two types of cell death. Cell death is significantly linked to tumor development, medication resistance, cancer recurrence, and metastatic dissemination. Therefore, a comprehensive understanding of cell death is essential for the treatment of cancer. Pyroptosis is a kind of PCD
Jie‐Lin Wang +5 more
openaire +3 more sources
Pyroptosis Plays a Role in Osteoarthritis [PDF]
Aging and disease, 2020 Recent studies have revealed novel forms of cell death beyond the canonical types of cellular apoptosis and necrosis, and these novel forms of cell death are induced by extreme microenvironmental factors. Pyroptosis, a type of regulated cell death, occurs when pattern recognition receptors (PRRs) induce the activation of cysteine-aspartic protease 1 ...
Yusheng Li, Senbo An, Yihe Hu, Huiyu Hu
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Scientific Reports, 2023 Pyroptosis is a kind of programmed cell death triggered by the inflammasome. Growing evidence has revealed the crucial utility of pyroptosis in tumors.
Jiayi Zeng +11 more
doaj +1 more source
Regulation of Pyroptosis by ncRNA: A Novel Research Direction
Frontiers in Cell and Developmental Biology, 2022 Pyroptosis is a novel form of programmed cell death (PCD), which is characterized by DNA fragmentation, chromatin condensation, cell swelling and leakage of cell contents.
Liyuan Gao +4 more
doaj +1 more source