Results 91 to 100 of about 13,199 (173)

Enantioselective Biotransformations of Racemic and Meso Pyrrolidine-2,5-dicarboxamides and Their Application in Organic Synthesis

open access: yes, 2016
In this paper, we report the amidase-catalyzed hydrolysis of pyrrolidine-2,5-dicarboxamides and their application in organic synthesis. Catalyzed by Rhodococcus erythropolis AJ270, an amidase containing microbial whole cell catalyst, racemic trans ...
Peng Chen (6514)   +4 more
core   +1 more source

From nature to nanoscale: advances, challenges, and preclinical translation of nanofiber drug delivery systems containing plant‐derived active ingredients

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract Since the early 1960s, nanotechnology has been a critical area of science, allowing for the development of sophisticated nanomaterials. Nanofibers, one of the most widely used nanotechnological drug delivery systems, have emerged as a highly versatile platform within modern pharmaceutical sciences.
Heybet Kerem Polat   +7 more
wiley   +1 more source

Taurine-Based Hybrid Drugs as Potential Anticancer Therapeutic Agents: In Vitro, In Vivo Evaluations

open access: yesPharmaceuticals
Background/Objectives: The development of antitumor agents possessing low toxicity against non-cancerous cells is still a challenge in medicinal chemistry. In this paper, we report the antitumor activity of “hybrid structures” derived from the amino acid
Saltanat Nakypova   +17 more
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

The continuing significance of chiral agrochemicals

open access: yesPest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

General Strategy for the Construction of Enantiopure Pyrrolidine-Based Alkaloids. Total Synthesis of (−)-Monomorine

open access: yes, 2016
An enantiopure cis-2,5-disubstituted pyrrolidine building block was prepared from cocaine. The synthetic utility of this compound as a chiral building block was demonstrated by a short and efficient synthesis of the pyrrolidine-based alkaloid ...
Liang Xu (102656)   +4 more
core   +1 more source

Super‐Electron‐Donor Polymers: From Monomer Design to Redox Functionality

open access: yesSmall, EarlyView.
2,2'‐Bipyridinylidenes are known for their “super‐electron‐donor” properties and have therefore been used beyond the field of organic synthesis. Their two‐electron redox process at a low potential of 1.8 V vs. Li/Li+ makes them attractive negative p‐type electrode‐active materials.
Luisa Rzesny   +9 more
wiley   +1 more source

An infrared investigation of Pyrrolidine-2-thione and -2-selenone

open access: yes, 1978
Pyrrolidine-2-thione and -2-selenone together with their N-deutero and S- and Se-methiodide derivatives have been studied by i.r. spectroscopy over the range 4000-200 cm-1. C=S and C=Se contribute to the bands at around 1000 cm-1 and below 600 cm-1.
FA Devillanova, G Verani
core   +1 more source

Pyrene‐linked heterocyclic pyrazoles: Synthesis, antimicrobial screening, and in silico molecular insights

open access: yesSmart Molecules, EarlyView.
A series of novel pyrene‐linked heterocyclic pyrazoles were synthesized and structurally characterized. The compounds were evaluated for antimicrobial activity against selected bacterial and fungal strains, showing promising inhibitory effects. Molecular docking studies provided insights into binding interactions and structure–activity relationships ...
Dinkal V. Kasundra, Paresh N. Patel
wiley   +1 more source

Recent Developments in Azomethine Ylide-Initiated Double Cycloadditions

open access: yesMolecules
Azomethine ylides (AMYs) have a nitrogen–carbon double bond and an electron lone pair on the nitrogen atom. They are essential 1,3-dipoles for [3+2] cycloadditions in the synthesis of pyrrolidine-containing heterocycles.
Tieli Zhou   +4 more
doaj   +1 more source

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