Results 91 to 100 of about 33,483 (272)

Trends in new psychoactive substance poisonings in the Netherlands: A 14‐year retrospective analysis (2012–2025)

open access: yesAddiction, EarlyView.
Abstract Background and aims Data on the presence of new psychoactive substances (NPS) mainly originate from drug‐checking, law enforcement and wastewater analysis sources, while data on NPS poisonings are scarce. In Europe, the documented incidence rate of NPS poisonings is highest in the Netherlands.
Johanna J. Nugteren‐van Lonkhuyzen   +5 more
wiley   +1 more source

Comprehensive in vitro profiling of traditional and emerging stimulants at monoamine transporters and the 5‐HT2A receptor

open access: yesBritish Journal of Pharmacology, EarlyView.
A pharmacological profiling of 58 synthetic stimulants of various classes at dopamine, norepinephrine, and serotonin transporters and the 5‐HT2A receptor, most showing distinct class‐dependent profiles, with some indicating a high abuse potential. Background and Purpose New psychoactive substances (NPSs) often emerge on the illicit drug market with ...
Darta Stalberga   +9 more
wiley   +1 more source

Metalloamination/Cyclization of Zinc(II) Amides Derived from N,N-Dimethylhydrazinoalkenes—Applications for the Direct C-SP2 Functionalization of Aryl and Vinyl Electrophiles

open access: yesInorganics
Treatment of N,N-dimethylhydrazinoalkenes with diethylzinc followed by exposure of the resulting ethylzinc amides to high vacuum drives a Schlenck redistribution metalloamination/cyclization to generate the corresponding bis(organozinc) intermediates in ...
Jérome Lépeule   +2 more
doaj   +1 more source

Deciphering Role of Endophytes in Plant Defences and Biotic Stress Resilience Across Families

open access: yesPlant, Cell &Environment, EarlyView.
ABSTRACT Plant families generate distinct repertoires of specialised metabolites that govern their biotic interactions. Endophytes strengthen host plant defence mechanisms and tolerance to biotic challenges by upregulating metabolite biosynthesis, modifying precursor compounds into more potent forms, or by directly synthesising analogous defence ...
S. Aneeqa Noor   +4 more
wiley   +1 more source

GK PUA Domain Modulates Cables, Cooperativity, and Proline Feedback

open access: yesAggregate, Volume 7, Issue 8, August 2026.
EcGK tetramers hierarchically assemble into metabolic filaments and bundle into metabolic cables. Upon substrate binding, this dynamic equilibrium shifts from inactive cables to active tetramers to drive catalysis; meanwhile the inhibitor proline stabilizes an X‐shaped conformation, redirecting assembly toward filaments to enable efficient feedback ...
Tianyi Zhang   +4 more
wiley   +1 more source

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

open access: yesMedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang   +3 more
wiley   +1 more source

Acyclic Hydrocarbon α,ω‐Dienes: From Biomass and Plastic Upcycling to Carbocycles, Precision Polymers, and Cross‐Linked Elastomers

open access: yesChemSusChem, Volume 19, Issue 14, 29 July 2026.
Hydrocarbon α,ω‐dienes are mainly produced from steam‐cracking derivatives, but high costs, complexity, and environmental impact limit their use. This review highlights sustainable paths from biomass and plastic upcycling, and surveys catalytic transformations into carbocycles and specialty polymers, emphasizing their role as modular building blocks ...
Rosa Villaccio, Giuseppe Leone
wiley   +1 more source

Catalytic Functionalization of Unactivated π‐Bonds Enabled by Bidentate Directing Auxiliaries

open access: yesAngewandte Chemie, Volume 138, Issue 28, 6 July 2026.
This review explores how bidentate directing auxiliaries have advanced transition‐metal catalysis for unactivated alkene/alkyne functionalization. By leveraging chelated intermediates, bidentate directing auxiliaries enable precise hydrofunctionalization, difunctionalization, and C─H activation of π‐bonds with unique selectivity and reactivity.
Seunghyeon Cho   +4 more
wiley   +2 more sources

Synthesis and Reactions of Pyrrolidine Derivatives from Succinimide

open access: diamond, 1982
Tatsuo Nagasaka   +5 more
openalex   +1 more source

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