Infrared Irradiation‐Assisted Pd/Cu Catalysis for Sustainable C–N Cross‐Coupling Reactions
European Journal of Organic Chemistry, EarlyView.A combined Pd/Cu catalytic system is demonstrated to be highly effective in promoting infrared irradiation‐assisted Buchwald–Hartwig aminations under nonanhydrous and open‐air conditions, using only a stoichiometric amount of a green reaction solvent.
Ambra M. Fiore +4 more
wiley +1 more source
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Acid‐Controlled Regional Diverse Synthesis of CF3‐Containing Ketoimines and Application in the Construction of Bispiro[oxindole‐pyrrolidine‐benzothiophenone]s [PDF]
, 2023 Shuo Sun +6 more
openalex +1 more source
The continuing significance of chiral agrochemicals
Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley +1 more source
ChemInform Abstract: An Organocatalytic Direct Mannich—Cyclization Cascade as [3 + 2] Annulation: Asymmetric Synthesis of 2,3‐Substituted Pyrrolidines. [PDF]
, 2012 Indresh Kumar +3 more
openalex +1 more source
Phytotherapy Research, EarlyView.Schematic representation of the experimental design and the proposed mechanisms underlying the cardioprotective and anti‐atherosclerotic effects of Greek‐derived berry extracts. C57BL/6 mice with WD–induced MS and ApoE−/− mice with atherosclerosis received chronic supplementation with WMex or BBex.
Lydia Symeonidi +15 more
wiley +1 more source
Catalytic Enantioselective Intramolecular Aza‐Michael Addition to α,β‐Unsaturated Esters
Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.A general method for accessing enantioenriched saturated N‐heterocycles via a catalytic enantioselective intramolecular aza‐Michael reaction to α,β‐unsaturated esters is described. A superbasic bifunctional iminophosphorane (BIMP) catalyst was key to enabling reactivity of the high pKa sulfonamide pronucleophile, whilst delivering good to excellent ...
Evan G. W. Rutter +5 more
wiley +2 more sources
Recent Developments in Azomethine Ylide-Initiated Double Cycloadditions
MoleculesAzomethine ylides (AMYs) have a nitrogen–carbon double bond and an electron lone pair on the nitrogen atom. They are essential 1,3-dipoles for [3+2] cycloadditions in the synthesis of pyrrolidine-containing heterocycles.
Tieli Zhou +4 more
doaj +1 more source
Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps [PDF]
, 2017 Xiaoqing Zheng +10 more
openalex +1 more source
The Chemical Record, EarlyView.This review highlights recent advances in the use of organic carbonates, dimethyl carbonate (DMC), diethyl carbonate (DEC), and propylene carbonate (PC), as solvents in organic synthesis. Based on over seventy studies from the past 6 years, it shows their application in different organic reaction types, emphasizing their role in safer and more ...
Gabriela T. Quadros +5 more
wiley +1 more source