Results 81 to 90 of about 13,199 (173)

Crystal structure of ethyl (2S,2′R)-1′-benzyl-3-oxo-3H-dispiro[1-benzothiophene-2,3′-pyrrolidine-2′,11′′-indeno[1,2-b]quinoxaline]-4′-carboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C35H27N3O3S, the spiro-linked five-membered rings both adopt twisted conformations. The pyrrolidine ring makes dihedral angles of 80.5 (1) and 77.4 (9)° with the benzothiophene ring system and the quinoxaline ring system ...
J. Govindaraj, R. Raja, M. Suresh, R. Raghunathan, A. SubbiahPandi   +4 more
doaj   +1 more source

Glycosidase-inhibiting pyrrolidine alkaloids from Hyacinthoides non-scripta

, 1997
The glycosidase-inhibiting pyrrolidine alkaloids (2R,3R,4R,5R)-2,5- dihydroxymethyl-3,4-dihydroxy-pyrrolidine (DMDP), 2,5-dideoxy-2,5-imino-DL- glycero-D-manno-heptitol (homoDMDP), homoDMDP-7-O-apioside and 1,4-dideoxy- 1,4-imino-D-arabinitol have been ...
Robert J. Nash, Mark R. Wormald, David J. Harvey, Rhodri C. Griffiths, Atsushi Kato, Stephen Dealler, Naoki Asano, Andrew J. Cairns, Haruhisa Kizu, Alison A. Watson, Eileen Lees, George W.J. Fleet   +11 more
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Navigating the Radical Oxo‐Functionalization of Alkenes Toward Ketones

European Journal of Organic Chemistry, EarlyView.
Straightforward access to complex ketones in a single synthetic step: This Review surveys the latest advances in three‐component alkene 1,2‐oxo‐functionalizations. The opportunities unlocked by the so‐called single‐electron (1e–) logic, including access to a broad pool of radical precursors and carbonyl oxygen atom sources, are highlighted.
Mattia Lepori, Luigi Dolcini, Alexander Bell, Joshua P. Barham   +3 more
wiley   +1 more source

The crystal structures of 6′-(4-chlorophenyl)- and 6′-(4-methoxyphenyl)-6a′-nitro-6a′,6b′,7′,9′,10′,12a′-hexahydro-2H,6′H,8′H-spiro[acenaphthylene-1,12′-chromeno[3,4-a]indolizin]-2-one

Acta Crystallographica Section E: Crystallographic Communications, 2019
In the title compounds, C32H25ClN2O4 (I) and C33H28N2O5 (II), the six-membered pyran and piperidine rings adopt envelope and chair conformations, respectively. The five-membered pyrrolidine rings adopt twist conformations. Compound (II) crystallizes with
S. Syed Abuthahir, M. NizamMohideen, V. Viswanathan, D. Velmurugan, J. Nagasivarao   +4 more
doaj   +1 more source

Gold‐Catalyzed Cyclization of Indole‐Tethered Alkynes Enabling Synthesis of Exocyclic Alkenyl Tetrahydrocarbazoles

European Journal of Organic Chemistry, EarlyView.
An efficient gold‐catalyzed intramolecular cyclization of indole‐tethered alkynes using AgNTf2 as an additive has been developed, which provides bioactive exocyclic alkenyl tetrahydrocarbazoles with up to 85% yield. Control experiments and DFT studies indicate that the reaction proceeds via a 6‐exo‐dig cyclization pathway, with gold acetylide complexes
Haibo Mei, Jingrui He, Chengting Wang, Jorge Escorihuela, Jianlin Han   +4 more
wiley   +1 more source

Alkaloids: Biosynthesis, Classification, and Biogenetic Relationships

Natural Product Communications, 2014
Stemona alkaloids form a unique class, which can be attributed to hemiterpenoid pyrrolidine- and monoterpenoid pyrrolidine-class alkaloids originated from L-ornithine and glutamic acid.
Feng-Peng Wang, Qiao-Hong Chen
doaj   +1 more source

Crystal structure of ethyl 2′′,3-dioxo-7′,7a'-dihydro-1′H,3H,3′H-dispiro[benzo[b]thiophene-2,6′-pyrrolo[1,2-c]thiazole-5′,3′′-indoline]-7′-carboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C23H20N2O4S2, the central pyrrolidine ring adopts an envelope conformation with the spiro C atom, shared with the benzothiophene ring system, as the flap.
M. P. Savithri, M. Suresh, R. Raghunathan, R. Raja, A. SubbiahPandi   +4 more
doaj   +1 more source

Fluorinated Iminosugar Glycomimetics: Synthesis and Activity as GCase Ligands

European Journal of Organic Chemistry, EarlyView.
DAST‐mediated deoxyfluorination of suitably functionalized piperidines provided regio‐ and stereoselective access to fluorinated piperidine and pyrrolidine glycomimetics, the latter arising from an unusual ring‐contraction process. Fluorination generally enhanced β‐glucocerebrosidase (GCase) inhibitory potency, but lost PC activity toward L444P/L444P ...
Francesca Mangiavacchi, Alessio Morano, Cosimo Margheri, Cristina Faggi, Amelia Morrone, Camilla Matassini, Francesca Clemente, Andrea Goti, Martina Cacciarini, Francesca Cardona   +9 more
wiley   +1 more source

Nutritional, Functional, and Analytical Characterization of Banana Blossom: A Waste Valorization Approach

Future Postharvest and Food, EarlyView.
Banana blossom (Musa paradisiaca spp.). Segregation of different parts (Pistil, Calyx, Bract, Stem). Nutritional, Functional and Analytical Characterisation. Bract has high carbohydrate, aminoacids and nutrient profile. Stem has high protein and colour stability. Pistil has better flavour binding, lipid interactions and strong cooking stability. Banana
Aamnesh Antonisamy, Sanakya Murugesan, Srithar Harimuthuvel, Suresh Kumar Kalakandan, Gururaj Pejavara Narayana, Sushmita Mandal   +5 more
wiley   +1 more source

Pyrrolidine derivatives

, 2015
[[abstract]]Pyrrolidine compounds described herein and methods for using them to inhibit dipeptidyl peptidase IV and treat Type II ...
Jiaang, WT;Chao, YS;Tsai, TY;Hsu, T
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