Results 101 to 110 of about 81,237 (352)

Diastereodivergent synthesis of chiral tetrahydropyrrolodiazepinediones via a one-pot intramolecular aza-Michael/lactamization sequence [PDF]

, 2018
A modular and diastereodivergent synthesis of tetrahydro-1H-pyrrolo[1,2d]diazepine-(2,5)-diones is presented. The tetrahydropyrrolodiazepinedione scaffold is obtained via a base-mediated three-step isomerization/tandem cyclization of amino acid-coupled ...
Brown, Lauren E., Chennamadhavuni, Spandan, Panek, James S., Porco, John A.   +3 more
core   +1 more source

Further Insights Into the Metabolism of LGD‐4033 in Human Urine. Part 1. Structure Elucidation of Additional Important Metabolites

Drug Testing and Analysis, EarlyView.
Well‐characterized, chemically synthesized molecules related to LGD‐4033 metabolism were used as analytical standards for the analysis of LGD‐4033 post‐administration urine samples. This approach offered further insights into LGD‐4033 metabolism, providing solid experimental proof for the structure of important previously reported metabolites and ...
Yiannis S. Angelis, Panagiotis Sakellariou, Mario Thevis, Andreas Thomas, Michael Petrou, Emmanuel N. Pitsinos   +5 more
wiley   +1 more source

5-Chloro-5′′-(4-chlorobenzylidene)-4′-(4-chlorophenyl)-1′′-ethyl-1′-methyldispiro[indoline-3,2′-pyrrolidine-3′,3′′-piperidine]-2,4′′-dione

Acta Crystallographica Section E, 2014
Two spiro links are found in the title compound, C31H28Cl3N3O2, one connecting the piperidine and pyrrolidine rings, and the other connecting the pyrrolidine ring and indole residue.
I. S. Ahmed Farag, Adel S. Girgis, A. A. Ramadan, A. M. Moustafa, Edward R. T. Tiekink   +4 more
doaj   +1 more source

Synthesis of thiazolidin-4-ones and thiazinan-4-ones from 1-(2-aminoethyl)pyrrolidine as acetylcholinesterase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
The present study describes the synthesis of a novel series of thiazolidin-4-one and thiazinan-4-one using 1-(2-aminoethyl)pyrrolidine as amine precursor. All compounds were synthesised by one-pot three component cyclocondensation reaction from the amine,
Adriana M. das Neves, Gabriele A. Berwaldt, Cinara T. Avila, Taís B. Goulart, Bruna C. Moreira, Taís P. Ferreira, Mayara S. P. Soares, Nathalia S. Pedra, Luiza Spohr, Anita A. A. dE Souza, Roselia M. Spanevello, Wilson Cunico   +11 more
doaj   +1 more source

Effect of Epigallocatechin‐3‐Gallate on Depression‐Related Cytokines in Thalassemia Patients: Molecular and Cellular Evaluation

Journal of Clinical Laboratory Analysis, EarlyView.
This study investigates the effects of Epigallocatechin‐3‐Gallate (EGCG), a potent anti‐inflammatory polyphenol isolated from Winged Marigold, on cytokine expression linked to depression in β‐thalassemia patients. EGCG demonstrated dose‐dependent suppression of key inflammatory cytokines (IL‐6, IL‐1β, TNF‐α, IFN‐γ) at both gene and protein levels ...
Mohammed N. Salman, Fouad Razzaq Al‐Burki, Hazim Ali Hussein, Laith A. Younus, Fadhil A. Nasser, Hasanain A. A. Almohseni   +5 more
wiley   +1 more source

The crystal structures and Hirshfeld surface analysis of 6-(naphthalen-1-yl)-6a-nitro-6,6a,6b,7,9,11a-hexahydrospiro[chromeno[3′,4′:3,4]pyrrolo[1,2-c]thiazole-11,11′-indeno[1,2-b]quinoxaline] and 6′-(naphthalen-1-yl)-6a′-nitro-6′,6a′,6b′,7′,8′,9′,10′,12a′-octahydro-2H-spiro[acenaphthylene-1,12′-chromeno[3,4-a]indolizin]-2-one

Acta Crystallographica Section E: Crystallographic Communications, 2019
The title compounds, 6-(naphthalen-1-yl)-6a-nitro-6,6a,6 b,7,9,11a-hexahydrospiro[chromeno[3′,4′:3,4]pyrrolo[1,2-c]thiazole-11,11′-indeno[1,2-b]quinoxaline], C37H26N4O3S, (I), and 6′-(naphthalen-1-yl)-6a′-nitro-6′,6a′,6b′,7′,8′,9′,10′,12a′-octahydro-2H ...
G. Foize Ahmad, A. Syed Mohammed Mujaheer, M. NizamMohideen, M. Gulam Mohamed, V. Viswanathan   +4 more
doaj   +1 more source

The role of copper in disulfiram-induced toxicity and radiosensitisation of cancer cells. [PDF]

, 2013
Disulfiram has been used for several decades in the treatment of alcoholism. It now shows promise as an anti-cancer drug and radiosensitizer. Proposed mechanisms of action include the induction of oxidative stress and inhibition of proteasome activity ...
Babich, John W, Boyd, Marie, Mairs, Robert J., Rae, Colin, Sorensen, Annette, Tesson, M.   +5 more
core   +1 more source

Influence of EDTA Coverage Density on Optical Fiber Sensor for Heavy Metal Ion Detection

Nano Select, EarlyView.
This study investigates the influence of chelating agent coverage on the performance of optical fiber sensors for heavy metal ion detection. Ethylenediaminetetraacetic acid (EDTA) was employed to functionalize single‐mode 28 optical fibers (SMF‐28), and the influence of surface coverage uniformity on zinc ion sensing performance was investigated ...
Zhejun Xu, Arun Jaiswal, Xiaochen Liu, Zhenxu Yang, Qiankun Yin, Ken‐Tye Yong   +5 more
wiley   +1 more source

Vinylogous aldol reaction of heterocyclic silyloxy dienes. Application in synthesis [PDF]

, 2000
A versatile, readily accessible triad of 2-enoxy silane synthons derived from furan, pyrrole, and thiophene is presented. These heterocycles, in reacting with carbonyl and carbonyl- related acceptors, act as vinylogous nucleophile modules, giving rise ...
Casiraghi, Giovanni, Rassu, Gloria Maria Rita, Zanardi, Franca   +2 more
core  

Opposite effects of two zinc(II) dithiocarbamates on NF-kB pathway [PDF]

, 2007
Inhibiting nuclear factor-kappaB (NF-kB) activation in anticancer and antiinflammatory therapy is of topical interest. Current research in molecular biology has dramatically advanced in the understanding of the cellular events involved in NF-kB induction.
Boris Cvek, Jan Taraba, Jitka Ulrichova, Lukas Muller, Radim Vrzal, Zdenek Dvorak   +5 more
core   +2 more sources