Results 21 to 30 of about 81,237 (352)

Discovery of 4-((3′R,4′S,5′R)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

Journal of Medicinal Chemistry, 2017
We previously reported the design of spirooxindoles with two identical substituents at the carbon-2 of the pyrrolidine core as potent MDM2 inhibitors.
A. Aguilar, Jianfeng Lu, Liu Liu, Ding Du, D. Bernard, D. McEachern, S. Przybranowski, Xiaoqin Li, Ruijuan Luo, Bo Wen, Duxin Sun, Hengbang Wang, J. Wen, Guang-Ye Wang, Y. Zhai, M. Guo, Dajun Yang, Shaomeng Wang   +17 more
semanticscholar   +1 more source

Crystal structure of ethyl 1′,1′′-dimethyl-2′′,3-dioxo-3H-dispiro[benzo[b]thiophene-2,3′-pyrrolidine-2′,3′′-indoline]-4′-carboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C23H22N2O4S, the pyrrolidine ring has an envelope conformation with the spiro C atom, shared with the indoline ring system, as the flap. The mean planes of the benzothiophene and indoline ring systems are inclined to the mean plane
M. P. Savithri, M. Suresh, R. Raghunathan, R. Raja, A. SubbiahPandi   +4 more
doaj   +1 more source

Asymmetric organocatalysis of the addition of acetone to 2-nitrostyrene using N-diphenylphosphinyl-1,2-diphenylethane-1,2-diamine (PODPEN) [PDF]

, 2010
The highly enantioselective addition of acetone to 2-nitrostyrene, using N–diphenylphosphinyl-trans-1,2-diphenylethane-1,2-diamine (PODPEN) as catalyst, is ...
A. Simon Partridge, Bernardi, Burns, Charles V. Manville, Chaun, Connon, Dahlin, Daugidas T. Racys, David J. Morris, Denmark, Eder, Fletcher, García-García, Gary Woodward, Gordon Docherty, Hayashi, Hine, Hine, Huang, Ju, Kohmura, Laars, Lattanzi, Li, Liu, Liu, Martin Wills, Massi, Mei, Melchiorre, Ni, Ni, Pansare, Rishel, Seayad, Sulzer-Mosse, Suzuki, Tan, Tan, Tan, Tsandi, Tsogeova, Vijaikumar, Wang, Wang, Wang, Watson, Xu, Xu, Xu, Xu, Xue, Yu, Zhang   +53 more
core   +1 more source

Ethyl 1-benzyl-1,2,3,3a,4,10b-hexa-hydro-pyrrolo-[2',3':3,4]pyrrolo-[1,2-a]benzimidazole-2-carboxyl-ate. [PDF]

, 2011
The title mol-ecule, C(22)H(23)N(3)O(2), was obtained via an intra-molecular cyclo-addition of an azomethine ylide and an alkene tethered by a benzimidazole unit. The benzoimidazole unit is essentially planar, with an r.m.s.
Fettinger, James C, Kurth, Mark J, Meng, Liping   +2 more
core   +2 more sources

N-Sulfinylpyrrolidine-containing ureas and thioureas as bifunctional organocatalysts

Beilstein Journal of Organic Chemistry, 2021
The synthesis of bifunctional N-sulfinylureas and thioureas with an appended pyrrolidine unit is presented. These organocatalysts were evaluated in Michael additions of aldehydes to nitroalkenes both under solvent-free conditions and in solution.
Viera Poláčková, Dominika Krištofíková, Boglárka Némethová, Renata Górová, Mária Mečiarová, Radovan Šebesta   +5 more
doaj   +1 more source

Alkaloids of the Genus Datura: Review of a Rich Resource for Natural Product Discovery

Molecules, 2021
The genus Datura (Solanaceae) contains nine species of medicinal plants that have held both curative utility and cultural significance throughout history.
Maris A. Cinelli, A. Daniel Jones
doaj   +1 more source

Nickel-catalyzed transamidation of aliphatic amide derivatives. [PDF]

, 2017
Transamidation, or the conversion of one amide to another, is a long-standing challenge in organic synthesis. Although notable progress has been made in the transamidation of primary amides, the transamidation of secondary amides has remained ...
Baker, Emma L, Dander, Jacob E, Garg, Neil K   +2 more
core   +1 more source

A Photocatalytic Method for the Degradation of Pyrrolidine in Water [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2000
A method for the degradation of pyrrolidine in water is described. The method relaies on the photocatalytic degradation of pyrrolidine to CO2 and NH3 by UV irradiation and using titanium dixide semiconductor as a photocatalyst.
Mohammad Hossein Habibi, Majid Mir Mohammad Sadeghi   +1 more
doaj  

Interaction of GABA and Excitatory Amino Acids in the Basolateral Amygdala: Role in Cardiovascular Regulation [PDF]

, 1997
Activation of the amygdala in rats produces cardiovascular changes that include increases in heart rate and arterial pressure as well as behavioral changes characteristic of emotional arousal.
Cook, Jennifer C., Gregg, Adam E., Sanders, Brian J., Soltis, Robert P.   +3 more
core   +2 more sources

N-(Pyrrolidin-1-ylcarbothioyl)benzamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
In the title compound, C(12)H(14)N(2)OS, the pyrrolidine ring adopts an envelope conformation with the C atom at the 3-position as the flap and makes a dihedral angle of 65.80 (9)° with the benzene ring. In the crystal, N-H⋯O hydrogen bonds join c-glide related mol-ecules into chains extended along [001] that are further connected into (100) layers via
Al-Abbasi, Aisha A., Mohamed Tahir, Mohamed Ibrahim, Kassim, Mohammad   +2 more
openaire   +3 more sources