Results 21 to 30 of about 70,546 (390)

Concise Synthesis of (+)-allo-Kainic Acid via MgI2-Mediated Tandem Aziridine Ring Opening-Formal [3+2] Cycloaddition [PDF]

, 2013
3-Methyl vinyl aziridine undergoes a mild MgI2-promoted S(N)2' ring opening and concomitant cyclization with fumarate Michael acceptors to give trisubstituted pyrrolidines. The process is efficient and highly diastereoselective. This methodology has been
Aggarwal, Varinder K., Arena, Giada, Chen, Chia-Chun, Leonori, Daniele   +3 more
core   +1 more source

Crystal structure of (−)-(5R,7R,8S,9R,10S)-8-methyl-7-[(5R)-3-methyl-2-oxooxolan-3-en-5-yl]-1-aza-6-oxatricyclo[8.3.0.05,9]tridecan-13-one monohydrate

Acta Crystallographica Section E: Crystallographic Communications, 2018
The title compound, C17H23NO4·H2O, is an epimer of the natural tetracyclic alkaloid isosaxorumamide which consists of a fused 5–7–5 tricyclic core and a dihydrofuranone substituent.
Takeshi Oishi, Makoto Yoritate, Takaaki Sato, Noritaka Chida   +3 more
doaj   +1 more source

X=Y–ZH compounds as potential 1,3-dipoles. Part 64: Synthesis of highly substituted conformationally restricted and spiro nitropyrrolidines via Ag(I) catalysed azomethine ylide cycloadditions [PDF]

, 2008
1,3-Dipolar reactions of imines of both acyclic and cyclic α-amino esters with a range of nitroolefins using a combination of AgOAc or Ag2O with NEt3 are described.
Albert, Amornraksa, Ayerbe, Becker, Berger, Bourguignon, Bryce, Cecilia Orgaz de la Cierva, Colin Kilner, Crooks, Dondas, Díaz-Ortiz, Fejes, Fejes, Gentles, Grigg, Grigg, Grigg, Grigg, Grigg, Grigg, Grigg, Grigg, Grigg, H. Ali Dondas, Hill, Kabalka, Krapcho, Lee, Mohammed A.B. Sarker, Nielson, Norman, Nyerges, Nyerges, Nyerges, Nyerges, Nyerges, Pak, Peterli, Pinna, Poornachandran, Poornachandran, Poornachandran, Ram, Rang, Ronald Grigg, Sader-Bakaouni, Shorter, Song, Thurkauf, Vivanco, Yan   +51 more
core   +1 more source

Crystal structure of 3′-(1H-indole-3-carbonyl)-1′-methyl-2-oxo-4′-(4-oxo-4H-chromen-3-yl)spiro[indoline-3,2′-pyrrolidine]-3′-carbonitrile

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C31H22N4O4, the pyrrolidine ring adopts a twist conformation on the N—CH2 bond. The indolin-2-one and the 1H-indole rings are nearly planar (r.m.s.
M. P. Savithri, R. Raja, D. Kathirvelan, B. S. R. Reddy, A. SubbiahPandi   +4 more
doaj   +1 more source

Beyond the Simple Copper(II) Coordination Chemistry with Quinaldinate and Secondary Amines

Molecules, 2020
Copper(II) acetate has reacted in methanol with quinaldinic acid (quinoline-2-carboxylic acid) to form [Cu(quin)2(CH3OH)]∙CH3OH (1) (quin− = an anionic form of the acid) with quinaldinates bound in a bidentate chelating manner.
Barbara Modec, Nina Podjed, Nina Lah
doaj   +1 more source

Ueber Carbonsäuren des Pyrrolidins [PDF]

Berichte der deutschen chemischen Gesellschaft, 1899
n ...
Willstätter, Richard, von Sicherer, Walther   +1 more
openaire   +3 more sources

Stereochemical diversity in pyrrolidine synthesis by catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides.

Chemical Communications, 2019
The pyrrolidine ring is a privileged structural motif in synthetic and medicinal chemisty. This review aims to highlight the high versatility of the catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides for access to different types of ...
J. Adrio, J. Carretero
semanticscholar   +1 more source

1-[6-Chloro-2-(phenanthren-9-yl)quinolin-4-yl]pyrrolidin-2-one

IUCrData, 2016
In the title compound, C27H19ClN2O, the quinoline system is planar, with a maximum deviation from the mean plane of 0.003 Å for the N atom. This ring makes dihedral angles of 56.64 (5) and 49.26 (2)° with phenanthrene and pyrrolidine rings, respectively.
Rajamani Raja, Subramani Kandhasamy, Uma Maheswari Narayanan, Paramasivam T. Perumal, Ramu Dhanapal   +4 more
doaj   +1 more source

Synthesis and biological evaluation of novel PDMP analogues [PDF]

, 2006
A new series of hybrid PDMP analogues, based both on PDMP and styryl analogues of natural ceramide, has been synthesized from D-serine. The synthetic route was developed such that future introduction of different aryl groups is straightforward ...
Boldin-Adamsky, Swetlana, Busson, Roger, Futerman, Anthony H, Hillaert, Ulrik, Rozenski, Jef, Van Calenbergh, Serge   +5 more
core   +1 more source

Discovery of 4-((3′R,4′S,5′R)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

Journal of Medicinal Chemistry, 2017
We previously reported the design of spirooxindoles with two identical substituents at the carbon-2 of the pyrrolidine core as potent MDM2 inhibitors.
A. Aguilar, Jianfeng Lu, Liu Liu, Ding Du, D. Bernard, D. McEachern, S. Przybranowski, Xiaoqin Li, Ruijuan Luo, Bo Wen, Duxin Sun, Hengbang Wang, J. Wen, Guang-Ye Wang, Y. Zhai, M. Guo, Dajun Yang, Shaomeng Wang   +17 more
semanticscholar   +1 more source