Results 81 to 90 of about 70,546 (390)

Ethyl 5-(4-Bromophenyl)-4-methyl-1H-pyrrole-2-carboxylate

Molbank, 2017
This note describes a sequence converting an oxime-substituted pyrrolidine into a trisubstituted pyrrole structure. The synthetic route is based on a double chlorination of the pyrrolidine substrate followed by the base induced formation of both an imine
Marcus Baumann, Ian R. Baxendale
doaj   +1 more source

Facile Synthesis of a Carbon Nano Dot‐Based Wearable Flexible Thermoelectric Device

Advanced Materials Technologies, EarlyView.
A wearable proto‐type device made with low‐cost, bio‐friendly, and environmentally safe materials that can be readily fabricated to generate energy from low waste temperatures is demonstrated. The Carbon Nano Dot composite thin films are supported by a flexible cellulose substrate that harnesses thermoelectric principles to generate power from body ...
Al Jumlat Ahmed, Joseph F. Olorunyomi, Shiqin Yan, Christopher D. Easton, Farnaz Zadehahmadi, Yannan Lu, Daniel Liang, Xavier Mulet, Cara M. Doherty   +8 more
wiley   +1 more source

Synthesis of pyrrolo[1,2-a]quinolines by formal 1,3-dipolar cycloaddition reactions of quinolinium salts

Beilstein Journal of Organic Chemistry, 2019
Quinolinium salts, Q+-CH2-CO2Me Br− and Q+-CH2-CONMe2 Br− (where Q = quinoline), were prepared from quinolines. Deprotonation of these salts with triethylamine promoted the reaction of the resulting quinolinium ylides (formally azomethine ylides) with ...
Anthony Choi, Rebecca M. Morley, Iain Coldham   +2 more
doaj   +1 more source

Topical diclofenac: Clinical effectiveness and current uses in osteoarthritis of the knee and soft tissue injuries [PDF]

, 2008
Background: Diclofenac is a commonly used non-steroidal anti-inflammatory drug (NSAID) for symptom control in osteoarthritis (OA) of the knee and soft tissue injuries.
Banning, M
core   +1 more source

Effective and Practical Stereoselective Synthesis of Nutlins Precursors by Immobilization of Privileged Chiral Mono‐Amidine Catalyst

Advanced Synthesis &Catalysis, EarlyView.
Abstract A strategy for the immobilization of Johnston's Mono(AMidine) catalyst (MAM) onto polystyrene, silica and hybrid silica‐polystyrene nanoparticles is presented. The catalyst activity was evaluated in the stereoselective aza‐Henry reaction leading to the pivotal β‐amino nitroalkane precursors of the anti‐cancer agents Nutlins (with Nutlin‐3a as ...
Sofia Toldo, Lorenzo Poletti, Graziano Di Carmine, Olga Bortolini, Carmela De Risi, Simona Felletti, Greta Compagnin, Alessandro Massi, Daniele Ragno   +8 more
wiley   +1 more source

Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone

Chemistry – A European Journal, Volume 28, Issue 67, December 1, 2022., 2022
The chemical evolution of polyketide natural products leads to the unprecedented combination of biosynthetically related fragments in arrangements not found in Nature. The pseudo‐natural product grismonone was identified to be a potent inhibitor of Hedgehog signaling – a bioactivity that is not shared by its guiding fragments.
Michael Grigalunas, Sohan Patil, Adrian Krzyzanowski, Axel Pahl, Jana Flegel, Beate Schölermann, Jianing Xie, Sonja Sievers, Slava Ziegler, Herbert Waldmann   +9 more
wiley   +1 more source

Transaminase‐Triggered Cascades for the Synthesis and Dynamic Kinetic Resolution of Chiral N‐Heterocycles

Angewandte Chemie, EarlyView.
A single‐step biocatalytic route to complex indolizidine and quinolizidine alkaloids is described that relies on transaminase‐triggered double intramolecular aza‐Michael methodology. In one case, a retro‐double intramolecular aza‐Michael reaction enables dynamic kinetic resolution. Abstract Biocatalysis is now a well‐established branch of catalysis and
Adam O'Connell, Marianne B. Haarr, James Ryan, Xingxing Xu, Aoife Martin, Simon N. Smith, Nadia Elghobashi‐Meinhardt, Patricia Fleming, Beatriz Maciá, Vittorio Caprio, Elaine O'Reilly   +10 more
wiley   +2 more sources

1-Ethyl 2-methyl 3,4-bis(acetyloxy)pyrrolidine-1,2-dicarboxylate: crystal structure, Hirshfeld surface analysis and computational chemistry

Acta Crystallographica Section E: Crystallographic Communications, 2020
The title compound, C13H19NO8, is based on a tetra-substituted pyrrolidine ring, which has a twisted conformation about the central C—C bond; the Cm—Ca—Ca—Cme torsion angle is 38.26 (15)° [m = methylcarboxylate, a = acetyloxy and me = methylene].
Sofia Dallasta Pedroso, Ignez Caracelli, Julio Zukerman-Schpector, Monica Soto-Monsalve, Regina H. De Almeida Santos, Carlos Roque D. Correia, Ariel L. Llanes Garcia, Huey Chong Kwong, Edward R. T. Tiekink   +8 more
doaj   +1 more source

Bioactivities of a New Pyrrolidine Alkaloid from the Root Barks of Orixa japonica

Molecules, 2016
A new pyrrolidine alkaloid named (Z)-3-(4-hydroxybenzylidene)-4-(4-hydroxyphenyl)-1-methylpyrrolidin-2-one was isolated from the ethanol extract of the root barks of Orixa japonica. The structure of the new alkaloid was elucidated on the basis of NMR and
X. Liu, D. Lai, Q. Liu, Ligang Zhou, Qiyong Liu, Z. Liu   +5 more
semanticscholar   +1 more source

Synthesis of spirolactones from carbonyls via carboborylation of N‐sulfonylhydrazones with alkoxycarbonylalkylboronic acids

Advanced Synthesis &Catalysis, Accepted Article.
A straightforward synthesis of spirolactones from carbonyls via N‐tosylhydrazones is described. The process consist in the reaction between the N‐tosylhydrazone and ethoxycarbonylethylboronic acid or ethoxycarbonylpropylboronic acid, leading to spiro γ‐butyrolactones or δ‐valerolactones respectively. The transformation takes place by carboborylation of
Lucía López, Sara Filgueira, María-Paz Cabal, Alfonso Carlos Valdés-Gómez   +3 more
wiley   +1 more source