Results 121 to 130 of about 17,768 (339)
Radical cascades using enantioenriched 7-azabenzonorbornenes and their applications in synthesis
Tandem deoxygenation–neophyl-type radical rearrangement–electrophile trapping using xanthates from 7-azabenzonorbornadienes gives 3-exo-substituted 2-aza-5,6-benzonorbornenes, which in some cases undergo isomerisation to (aminomethyl)indenes.
David M. Hodgson, Leonard H. Winning
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Silyl-substituted pyrrolidines have gained increased interest for the design of new catalyst scaffolds. The molecular structures of four enantiomerically-pure 2-silylpyrrolidinium salts are reported.
Jonathan O. Bauer, Carsten Strohmann
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Drug-like spirocyclic scaffolds have been prepared by fusing fully functionalized pyrrolidine with oxindoles in an approach based on 1,3-dipolar cycloaddition.
Wen Ren+5 more
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This article presents the synthesis of new derivatives of spirooxindole-spiropiperidinone- pyrrolidines 6a–j and spirooxindole-spiropiperidinone-pyrrolizines 8a–j, through a 1,3-dipolar cycloaddition reaction of azomethineylides generated from isatin ...
Huwaida M. E. Hassaneen+4 more
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Skeletal contraction: A novel strategy to access multisubstituted cyclobutane
The polysubstituted and spirocyclic cyclobutanes were efficiently constructed by the utilization of a novel skeletal contraction strategy which only took one-step synthesis from the readily accessible pyrrolidines.
Chunfa Xu+2 more
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Advancements in the diastereoselective synthesis of acyl pyrrolidines via the tandem aza-Cope—Mannich cyclization pathway [PDF]
We have developed a Lewis-acid catalyzed, diastereoselective aza-Cope rearrangement— Mannich cyclization to form acyl pyrrolidines from conformationally mobile substrates.
St. Germaine, Danielle
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Studies toward New Anti-Cancer Strategies Based on ?-Mannosidase Inhibition
Changes in the glycosylation pattern of cellular glycoproteins constitute a hallmark in human cancer and influence tumor progression, suggesting that inhibitors of selected glycosidases may control cancer progression.
Sandrine Gerber-Lemaire+1 more
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Plant enzyme reactions leading to the formation of heterocyclic compounds. 1. The formation of unsaturated pyrrolidine and piperidine compounds [PDF]
P. J. Mann, W. R. Smithies
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Novel studies on enamine and acid organocatalysis on carbon-carbon bond forming reactions [PDF]
378 p.Los cicloaductos derivados de prolina no naturales densamente funcionalizados NO2-XL-OMe 5aa y NO2 NL-OMe 5aa poseen un gran interés en los campos de la química y biología ya que pueden complementar a los aminoácidos naturales. Por ello, se decidió
Ruiz-Olalla Fernández, Andrea
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Development of contractive synthesis of cyclobutanes from pyrrolidines [PDF]
Carbocycles are omnipresence in chemical pharmaceuticals, biologically active natural products and organic functional materials. Construction of structurally intriguing, highly functionalized small carbocycles with congested stereocenters remain to be an
Hui, Chun-Ngai
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