Results 121 to 130 of about 17,768 (339)

Radical cascades using enantioenriched 7-azabenzonorbornenes and their applications in synthesis

open access: yesBeilstein Journal of Organic Chemistry, 2008
Tandem deoxygenation–neophyl-type radical rearrangement–electrophile trapping using xanthates from 7-azabenzonorbornadienes gives 3-exo-substituted 2-aza-5,6-benzonorbornenes, which in some cases undergo isomerisation to (aminomethyl)indenes.
David M. Hodgson, Leonard H. Winning
doaj   +1 more source

Molecular Structures of Enantiomerically-Pure (S)-2-(Triphenylsilyl)- and (S)-2-(Methyldiphenylsilyl)pyrrolidinium Salts

open access: yesInorganics, 2017
Silyl-substituted pyrrolidines have gained increased interest for the design of new catalyst scaffolds. The molecular structures of four enantiomerically-pure 2-silylpyrrolidinium salts are reported.
Jonathan O. Bauer, Carsten Strohmann
doaj   +1 more source

Efficient Synthesis of Fully Substituted Pyrrolidine-Fused 3-Spirooxindoles via 1,3-Dipolar Cycloaddition of Aziridine and 3-Ylideneoxindole

open access: yesMolecules, 2016
Drug-like spirocyclic scaffolds have been prepared by fusing fully functionalized pyrrolidine with oxindoles in an approach based on 1,3-dipolar cycloaddition.
Wen Ren   +5 more
doaj   +1 more source

Facial Regioselective Synthesis of Novel Bioactive Spiropyrrolidine/Pyrrolizine-Oxindole Derivatives via a Three Components Reaction as Potential Antimicrobial Agents

open access: yesMolecules, 2017
This article presents the synthesis of new derivatives of spirooxindole-spiropiperidinone- pyrrolidines 6a–j and spirooxindole-spiropiperidinone-pyrrolizines 8a–j, through a 1,3-dipolar cycloaddition reaction of azomethineylides generated from isatin ...
Huwaida M. E. Hassaneen   +4 more
doaj   +1 more source

Skeletal contraction: A novel strategy to access multisubstituted cyclobutane

open access: yesGreen Synthesis and Catalysis, 2022
The polysubstituted and spirocyclic cyclobutanes were efficiently constructed by the utilization of a novel skeletal contraction strategy which only took one-step synthesis from the readily accessible pyrrolidines.
Chunfa Xu   +2 more
doaj  

Advancements in the diastereoselective synthesis of acyl pyrrolidines via the tandem aza-Cope—Mannich cyclization pathway [PDF]

open access: yes, 2014
We have developed a Lewis-acid catalyzed, diastereoselective aza-Cope rearrangement— Mannich cyclization to form acyl pyrrolidines from conformationally mobile substrates.
St. Germaine, Danielle
core   +1 more source

Studies toward New Anti-Cancer Strategies Based on ?-Mannosidase Inhibition

open access: yesCHIMIA, 2010
Changes in the glycosylation pattern of cellular glycoproteins constitute a hallmark in human cancer and influence tumor progression, suggesting that inhibitors of selected glycosidases may control cancer progression.
Sandrine Gerber-Lemaire   +1 more
doaj   +1 more source

Novel studies on enamine and acid organocatalysis on carbon-carbon bond forming reactions [PDF]

open access: yes, 2016
378 p.Los cicloaductos derivados de prolina no naturales densamente funcionalizados NO2-XL-OMe 5aa y NO2 NL-OMe 5aa poseen un gran interés en los campos de la química y biología ya que pueden complementar a los aminoácidos naturales. Por ello, se decidió
Ruiz-Olalla Fernández, Andrea
core   +1 more source

Development of contractive synthesis of cyclobutanes from pyrrolidines [PDF]

open access: yes, 2021
Carbocycles are omnipresence in chemical pharmaceuticals, biologically active natural products and organic functional materials. Construction of structurally intriguing, highly functionalized small carbocycles with congested stereocenters remain to be an
Hui, Chun-Ngai
core  

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