Synthesis of enantiomeric polyhydroxyalkylpyrrolidines from 1,3-dipolar cycloadducts. Evaluation as inhibitors of a β-galactofuranosidase [PDF]
, 2016 Enantiomeric 2,3,4-tris(hydroxyalkyl)-5-phenylpyrrolidines have been synthesized from the major cycloadducts obtained by the 1,3-dipolar cycloaddition of sugar enones with azomethine ylides derived from natural amino acids.
Oliveira Udry, Guillermo Alejandro +3 more
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Synthesis of 1-phenyl-3-pyrroline in water
Orbital: The Electronic Journal of Chemistry, 2012 Pyrrolines are bioactive compounds and can be used as starting materials or as intermediates in the synthesis of natural products [1,2]. N-phenyl-pyrrolines have been prepared by reaction of N-propargylanilines catalyzed by Cu(I) [3] or the ring-closing ...
Thiago Muniz de Souza +2 more
doaj +1 more source
Copper(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of 1,3-enynes and azomethine ylides
Nature Communications, 2023 Herein, we report a copper(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides and 1,3-enynes, which provides a series of chiral poly-substituted pyrrolidines in high regio-, diastereo-, and enantioselectivities. Both 4-aryl-1,3-enynes
Bo-Ran Wang +6 more
doaj +1 more source
Silver and platinum-catalysed addition of O–H and N–H bonds to allenes [PDF]
, 2014 Transition-metal catalysed nucleophile addition to allenes is a very powerful tool for the synthesis of functionalised molecules containing heteroatoms, heterocycles in the intramolecular version, or allyl derivatives in the intermolecular version.
Munoz-Herranz, Maria
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1,3-Dipolar Cycloadditions of N-Benzyl Furfuryl Nitrones with Electron-rich Alkenes
Molecules, 2000 The 1,3-dipolar cycloaddition reaction of N-benzyl-C-(2-furyl)nitrones with electron-rich alkenes gives preferentially trans-substituted 3,5-disubstituted isoxazolidines (endo approach).
Tomas Tejero +3 more
doaj +1 more source
Concise Synthesis of (+)-allo-Kainic Acid via MgI2-Mediated Tandem Aziridine Ring Opening-Formal [3+2] Cycloaddition [PDF]
, 2013 3-Methyl vinyl aziridine undergoes a mild MgI2-promoted S(N)2' ring opening and concomitant cyclization with fumarate Michael acceptors to give trisubstituted pyrrolidines. The process is efficient and highly diastereoselective. This methodology has been
Aggarwal, Varinder K. +3 more
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Buflomedil for intermittent claudication [PDF]
, 2013 Background : Intermittent claudication (IC) is pain caused by chronic occlusive arterial disease, that develops in a limb during exercise and is relieved with rest. Buflomedil is a vasoactive agent used to treat peripheral vascular disease.
De Backer, Tine, Vander Stichele, Robert
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Stereoselective synthesis of functionalized pyrrolidines by the diverted NH insertion reaction of metallocarbenes with β-aminoketone derivatives [PDF]
, 2016 A highly stereoselective route to functionalized pyrrolidines from the metal catalyzed diverted N-H insertion of a range of diazocarbonyl compounds with β-aminoketone derivatives is described. A number of catalysts (rhodium(II) carboxylate dimers, copper(
Aviv +38 more
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Bis(oxotremorine) fumarate bis(fumaric acid)
IUCrData, 2022 The title compound, bis(oxotremorine) fumarate bis(fumaric acid) {systematic name: 1-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]pyrrolidinium (2E)-but-2-enedioate bis[(2E)-but-2-enedioic acid]}, 2C12H19N2O+·C4H2O42−·2C4H4O4, has a single oxotremorine monocation
Marilyn Naeem +3 more
doaj +1 more source
Recent advances in the catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides [PDF]
, 2014 Catalytic asymmetric 1,3-dipolar cycloadditions of azomethine ylides have turned out to be one of the most efficient methods for the preparation of enantioenriched pyrrolidines.
Adrio, Javier, Carretero, Juan C.
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