Protective effects of pyrroloquinoline quinone in brain folate deficiency [PDF]
Fluids and Barriers of the CNS, 2023 Background Folates (Vitamin B9) are critical for normal neurodevelopment and function, with transport mediated by three major pathways: folate receptor alpha (FRα), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC).
Vishal Sangha +3 more
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Pyrroloquinoline-quinone to reduce fat accumulation and ameliorate obesity progression [PDF]
Frontiers in Molecular Biosciences, 2023 Obesity is a major health concern worldwide, and its prevalence continues to increase in several countries. Pyrroloquinoline quinone (PQQ) is naturally found in some foods and is available as a dietary supplement in its disodium crystal form.
Nur Syafiqah Mohamad Ishak +1 more
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Pyrroloquinoline quinone: a potential neuroprotective compound for neurodegenerative diseases targeting metabolism [PDF]
Neural Regeneration ResearchPyrroloquinoline quinone is a quinone described as a cofactor for many bacterial dehydrogenases and is reported to exert an effect on metabolism in mammalian cells/tissues.
Alessio Canovai, Pete A. Williams
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Neuroprotective role of pyrroloquinoline quinone in folate deficiency-induced blood-brain barrier disruption [PDF]
Fluids and Barriers of the CNSHealthy neurodevelopment requires adequate folates (vitamin B9), which are critical for key biosynthetic and homeostatic processes in the central nervous system (CNS).
Sara Aboulhassane +3 more
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Pyrroloquinoline Quinone (PQQ): Its impact on human health and potential benefits [PDF]
Current Research in Food SciencePyrroloquinoline Quinone (PQQ) is a redox-active quinone molecule with significant implications for human health. Originally identified as a bacterial cofactor, PQQ has since been lauded for its diverse biological and therapeutic activities. It serves as
Tingdong Yan +10 more
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Pyrroloquinoline quinone inhibits PCSK9-NLRP3 mediated pyroptosis of Leydig cells in obese mice [PDF]
Cell Death and Disease, 2023 Abnormal lipid metabolism and chronic low-grade inflammation are the main traits of obesity. Especially, the molecular mechanism of concomitant deficiency in steroidogenesis-associated enzymes related to testosterone (T) synthesis of obesity dominated a ...
Jinyuan Wang +21 more
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Pyrroloquinoline Quinone Improved Boar Sperm Quality via Maintaining Mitochondrial Function During Cryopreservation [PDF]
AntioxidantsDue to oxidative damage and mitochondrial dysfunction, boar semen cryopreservation remains a significant challenge. This study investigates the effects of pyrroloquinoline quinone (PQQ), a mitochondrial-targeted antioxidant, on the post-thaw boar sperm ...
Shanpeng Wang +6 more
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Effects of pyrroloquinoline quinone on noise-induced and age-related hearing loss in mice [PDF]
Scientific Reports, 2022 We investigated whether the oxidoreductase cofactor pyrroloquinoline quinone (PQQ) prevents noise-induced and age-related hearing loss (NIHL and ARHL) in mice.
Ying Gao +4 more
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Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection [PDF]
Acta Neuropathologica Communications, 2023 Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range.
Alessio Canovai +7 more
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Dietary supplementation with pyrroloquinoline quinone promotes growth, relieves weaning stress, and regulates metabolism of piglets compared with adding zinc oxide [PDF]
Animal Nutrition, 2023 Hindered growth often occurs because of psychological and environmental stress during the weaning period of piglets. This study aimed to compare the effects of growth performance, diarrhea indices, digestibility of nutrients, antioxidant capacity ...
Chenyu Shi +6 more
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