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Nephrotoxicity of Pyrroloquinoline Quinone in Rats

Nephrotoxicity of Pyrroloquinoline Quinone in Rats
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Method of enzymatic determination of pyrroloquinoline quinone

Analytical Biochemistry, 1985
An improved enzymatic method for the determination of pyrroloquinoline quinone, a novel prosthetic group of some important oxidoreductases, has been developed with cytoplasmic membrane of Escherichia coli K-12, in which D-glucose dehydrogenase (EC 1.1.99.17) was completely resolved to apo-enzyme by EDTA treatment.
Kazunobu Matsushita, M Ameyama, Emiko Shinagawa   +2 more
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The Cofactor Pyrroloquinoline Quinone

Annual Review of Nutrition, 1990
Article de synthese sur un cofacteur: la pyrroloquinoleine quinone. Etude de ses proprietes; caracteristiques, formes moleculaires, stabilite. Identification et analyse quantitative des formes libres, derivees et liees par liaison covalente. Distribution chez les procaryotes, les eucaryotes, les aliments et les boissons.
J A, Duine, R A, van der Meer, B W, Groen   +2 more
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Microbial synthesis of pyrroloquinoline quinone

World Journal of Microbiology and Biotechnology, 2023
Pyrroloquinoline quinone (PQQ) is a peptide-modified natural product. PQQ has important physiological functions such as anti-oxidation, anti-aging, and immunity enhancement. However, due to the lack of in-depth understanding of PQQ biosynthesis and regulation, inefficient PQQ production level limits its wide application.
Hao, Gao, Yingshan, Wang, Jiahui, Yang, Min, Qiu, Zhixiao, Lei, Wenming, Zhang, Wankui, Jiang, Fengxue, Xin, Min, Jiang   +8 more
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Pyrroloquinoline Quinone Chemistry, Biology, and Biosynthesis

Chemical Research in Toxicology, 2022
The widely distributed, essential redox factor pyrroloquinoline quinone (PQQ, methoxatin) (1) was discovered in the mid-1960s. The breadth and depth of its biological effects are steadily being revealed, and understanding its biosynthesis at the genomic level is a continuing process.
Geoffrey A. Cordell, Sharna-kay Daley
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Nutritional Importance of Pyrroloquinoline Quinone

Science, 1989
Mice fed a chemically defined diet devoid of pyrroloquinoline quinone (PQQ) grew poorly, failed to reproduce, and became osteolathyritic. Moreover, severely affected mice had friable skin, skin collagen that was readily extractable into neutral salt solutions, and decreased lysyl oxidase.
J, Killgore, C, Smidt, L, Duich, N, Romero-Chapman, D, Tinker, K, Reiser, M, Melko, D, Hyde, R B, Rucker   +8 more
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Detection of the cofactor pyrroloquinoline quinone

Analytical Biochemistry, 1987
In order to demonstrate the presence or absence of a pyrroloquinoline quinone (PQQ) synthesizing capacity in microorganisms, we have found that media and equipment must be treated to remove contaminating PQQ. Procedures are described which appear to be effective for that purpose.
M A, van Kleef, P, Dokter, A C, Mulder, J A, Duine   +3 more
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Pyrroloquinoline Quinone: A Novel Cofactor

1989
Publisher Summary This chapter discusses the properties, distribution, and biosynthesis of pyrroloquinoline quinine (PQQ). PQQ is an essential cofactor for several key enzymes in physiological processes in mammals. Development of inhibitors specifically directed to PQQ might reveal the role of PQQ and quinoproteins, but also that of vitamin B, and ...
J A, Duine, J A, Jongejan
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A Periplasmic Binding Protein for Pyrroloquinoline Quinone

Biochemistry, 2019
Pyrroloquinoline quinone (PQQ) is an essential redox cofactor in bacterial calcium- and lanthanide-dependent alcohol dehydrogenases. Although certain bacteria are known to synthesize and secrete PQQ, little is known about trafficking of this cofactor within and between cells.
Jackson V. Ho, Joseph A. Cotruvo
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Nephrotoxicity of pyrroloquinoline quinone in rats.

Hiroshima journal of medical sciences, 1989
When pyrroloquinoline quinone (PQQ) was intraperitoneally injected into rats daily for 4 days at a dose of 11.5 mg/kg body weight/injection, functional and morphologic changes of the kidneys were clearly observed. The most prominent finding was necrotic and degenerative changes of the proximal tubular epithelium as well as hematuria and an elevation of
Watanabe, Akiharu, Hobara, Norio, Ohsawa, Toshiya, Higashi, Toshihiro, Tsuji, Takao   +4 more
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