Results 71 to 80 of about 31,406 (163)

Silibinin Modulates NF‐κB Activation and Heat Shock Protein in Preeclampsia‐Like Rat Model

American Journal of Reproductive Immunology, Volume 96, Issue 1, July 2026.
ABSTRACT Problem Preeclampsia (PE) is a serious human pregnancy complication and remains the most complex hypertensive disorder due to its multifactorial nature and multisystemic effects. Despite the incomplete understanding of the PE pathophysiology, it is well‐accepted that placental changes in PE are associated with oxidative stress, increasing the ...
C. F. Bannwart‐Castro, M. Romao‐Veiga, V. R. Ribeiro‐Vasques, M. T. S. Peracoli, J. C. Peracoli   +4 more
wiley   +1 more source

Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 24: Suitability of taxonomic units notified to EFSA until March 2026

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The Qualified Presumption of Safety (QPS) process was developed to provide a harmonised safety assessment approach to support EFSA Scientific Panels and Units. The QPS approach assesses the taxonomic identity, body of knowledge and safety of microorganisms intentionally added to the food and feed chain.
EFSA Panel on Biological Hazards (BIOHAZ), Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Liesbeth Jacxsens, Maarten Nauta, Lapo Mughini‐Gras, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panagiotis Skandamis, Elisabetta Suffredini, Marianne Chemaly, Pier Sandro Cocconcelli, Pablo Salvador Fernández Escámez, Miguel Prieto Maradona, Amparo Querol, Lolke Sijtsma, Ingvar Sundh, Fulvio Barizzone, Marta Bisaschi, Sandra Correia, Lieve Herman   +26 more
wiley   +1 more source

A Periplasmic Binding Protein for Pyrroloquinoline Quinone

, 2019
Pyrroloquinoline quinone (PQQ) is an essential redox cofactor in bacterial calcium- and lanthanide-dependent alcohol dehydrogenases. Although certain bacteria are known to synthesize and secrete PQQ, little is known about trafficking of this cofactor ...
Jackson V. Ho (6750866), Joseph A. Cotruvo (2223247)   +1 more
core   +1 more source

A ‘Genome‐First’ Framework for Next‐Generation Bioinputs: From Functional Mining to Rational Synthetic Microbial Communities

Environmental Microbiology, Volume 28, Issue 5, May 2026.
I propose a ‘genome‐first’ framework to collapse the phenotypic bottleneck in bioinput discovery. By integrating multi‐layered genome mining and reverse ecology, this paradigm enables the rational design of stable synthetic microbial communities for a data‐driven and sustainable agricultural bioeconomy.
Osiel Silva Gonçalves
wiley   +1 more source

Pyrroloquinoline Quinone Protects SMA560 Astrocytes Against Thrombin-Induced Cell Death by Improving Mitochondrial Function

Natural Product Communications, 2022
Thrombin activation after cerebral hemorrhage induces the death of neurons and astrocytes. Pyrroloquinoline quinone (PQQ) shows nutritional functions and cell protection.
Xi Xu, Xiaochun Zhang, Yanyan Zhao, Xiangyan Liang, Lijun Zhang, Yu-Feng Zhao   +5 more
doaj   +1 more source

Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone

, 2004
The biosynthesis of pyrroloquinoline quinone (PQQ), a vitamin and redox cofactor of quinoprotein dehydrogenases, is facilitated by an unknown pathway that requires the expression of six genes, pqqA to -F.
Toyama, Hirohide, Magnusson, Olafur Th., Saeki, Megumi, Rojas Mendoza, Ana M., Klinman, Judith P., Liddington, Robert C., Schwarzenbacher, Robert, Reed, John C.   +7 more
core   +1 more source

Discovery of Hydroxylase Activity for PqqB Provides a Missing Link in the Pyrroloquinoline Quinone Biosynthetic Pathway [PDF]

, 2019
Understanding the biosynthesis of cofactors is fundamental to the life sciences, yet to date a few important pathways remain unresolved. One example is the redox cofactor pyrroloquinoline quinone (PQQ), which is critical for C1 metabolism in many ...
Robert L. Evans, Evans, Robert L, Wilmot, Carrie, Iavarone, Anthony, Iavarone, Anthony T, Evans, Robert L., Evans, Robert, Koehn, Eric M., Anthony T. Iavarone (331018), Eric M. Koehn, John A. Latham, Latham, John, Tara Armand (6406352), Armand, Tara, Iavarone, Anthony T., Judith P. Klinman, Latham, John A, Wilmot, Carrie M., Carrie M. Wilmot (1864492), Carrie M. Wilmot, Klinman, Judith, Robert L. Evans (4022570), Tara Armand, Klinman, Judith P, Tu, Xiongying, Xiongying Tu, Anthony T. Iavarone, John A. Latham (1328577), Xiongying Tu (6406355), Judith P. Klinman (189488), Latham, John A., Eric M. Koehn (2107003), Klinman, Judith P., Koehn, Eric, Koehn, Eric M, Wilmot, Carrie M   +35 more
core   +1 more source

Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria‐Mediated Intestinal Aging and Barrier Dysfunction

Aging Cell, Volume 25, Issue 5, May 2026.
Environmentally relevant enrofloxacin accelerates intestinal aging by impairing epithelial mitochondrial function, disrupting barrier integrity, and reshaping the gut microbiota. Mitochondrial restoration with pyrroloquinoline quinone alleviates hypoxia, inflammation, and gut damage.
Kan Yu, Nengzheng Wang, Xinyi Huang, Yushu Qiu, Xuejian He, Xiaofeng Zhu, Xiaolan Zhou, Peng Yu, Gang Wei, Yan Pi, Ting Ni   +10 more
wiley   +1 more source

Pyrroloquinoline‐quinone: a reactive oxygen species scavenger in bacteria

, 2004
Transgenic Escherichia coli expressing pyrroloquinoline-quinone (PQQ) synthase gene from Deinococcus radiodurans showed superior survival during Rose Bengal induced oxidative stress.
Misra, Hari S., Barik, Atanu, Atanu Barik, Priyadarsini, K. Indira, Hari S. Misra, Shree K. Apte, K. Indira Priyadarsini, Nivedita P. Khairnar, Apte, S., Hari Mohan, Khairnar, Nivedita P., Mohan, Hari   +11 more
core   +1 more source

Alpha Hope, via Molecular Hydrogen and Pyrroloquinoline Quinone, Dose-Dependently Increases Nrf2 and PGC-1α Levels in C2C12 Myoblasts

, 2023
Alpha Hope is a dietary supplement containing pyrroloquinoline quinone and elemental magnesium, which produces molecular hydrogen (H2 gas) when dissolved in water.
Joshua Y. Shirazi, Zhang, Yufeng, Keith Martin, Bloomer, Richard J., Tyler W. LeBaron, Yufeng Zhang, Richard J. Bloomer, Jacquelyn Pence, Judi Q. Timmcke, Shirazi, Joshua Y., Chidimma Okegbe, Martin, Keith, Pence, Jacquelyn, Q. Timmcke, Judi, LeBaron, Tyler W., Okegbe, Chidimma   +15 more
core   +1 more source