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Pyruvate kinase activators for treatment of pyruvate kinase deficiency. [PDF]

Hematology Am Soc Hematol Educ Program, 2023
Abstract Pyruvate kinase (PK) deficiency is a congenital hemolytic anemia with wide-ranging clinical symptoms and complications associated with significant morbidity and reduced health-related quality of life in both children and adults.
Grace RF.
europepmc   +4 more sources

Protein kinase function of pyruvate kinase M2 and cancer

Cancer Cell International, 2020
Pyruvate kinase is a terminal enzyme in the glycolytic pathway, where it catalyzes the conversion of phosphoenolpyruvate to pyruvate and production of ATP via substrate level phosphorylation.
Xun Chen, Shangwu Chen, Dongsheng Yu
doaj   +2 more sources

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis

Frontiers in Oncology, 2020
Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is catalyzed by Pyruvate Kinase. There are four isomeric, tissue-specific
Kulsoom Zahra, Tulika Dey, Ashish, Surendra Pratap Mishra, Uma Pandey   +4 more
doaj   +2 more sources

Pyruvate kinase deficiency

Haematologica, 2007
Over the past few years the inherited disorders of erythrocyte metabolism have been the object of intensive research which has resulted in a better understanding of their molecular basis. However, curative therapy for red blood cell (RBC) enzyme defects still remains undeveloped.
Alberto Zanella, Paola Bianchi, Elisa Fermo   +2 more
doaj   +4 more sources

Pyruvate kinase directly generates GTP in glycolysis, supporting growth and contributing to guanosine toxicity [PDF]

mBio
Guanosine triphosphate (GTP) is essential for macromolecular biosynthesis, and its intracellular levels are tightly regulated in bacteria. Loss of the alarmone (p)ppGpp disrupts GTP regulation in Bacillus subtilis, causing cell death in the presence of ...
Fukang She, Kuanqing Liu, Brent W. Anderson, Tippapha Pisithkul, Yanxiu Li, Danny K. Fung, Tyler McCue, William Mulhern, Daniel Amador-Noguez, Jue D. Wang   +9 more
doaj   +2 more sources

Allosteric regulation of pyruvate kinase enables efficient and robust gluconeogenesis by preventing metabolic conflicts and carbon overflow [PDF]

mSystems
Gluconeogenesis, the reciprocal pathway of glycolysis, is an energy-consuming process that generates glycolytic intermediates from non-carbohydrate sources. In this study, we demonstrate that robust and efficient gluconeogenesis in bacteria relies on the
Fukang She, Brent W. Anderson, Daven B. Khana, Shenwei Zhang, Wieland Steinchen, Danny K. Fung, Nathalie G. Lesser, Lauren N. Lucas, David M. Stevenson, Theresa J. Astmann, Gert Bange, Jan-Peter van Pijkeren, Daniel Amador-Noguez, Jue D. Wang   +13 more
doaj   +2 more sources

Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells

Cancer & Metabolism, 2019
Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options. Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in PDAC cells, but its role in pancreatic cancer remains controversial.
Lei Yu, Shao Thing Teoh, Elliot Ensink, Martin P. Ogrodzinski, Che Yang, Ana I. Vazquez, Sophia Y. Lunt   +6 more
doaj   +2 more sources

Studies on the Enolization of Pyruvate by Pyruvate Kinase [PDF]

Journal of Biological Chemistry, 1960
Irwin A. Rose
openalex   +3 more sources

Mitapivat versus Placebo for Pyruvate Kinase Deficiency.

New England Journal of Medicine, 2022
BACKGROUND Pyruvate kinase deficiency is a rare, hereditary, chronic condition that is associated with hemolytic anemia. In a phase 2 study, mitapivat, an oral, first-in-class activator of erythrocyte pyruvate kinase, increased the hemoglobin level in ...
Hanny Al‐Samkari, F. Galactéros, A. Glenthøj, J. Rothman, O. Andres, R. Grace, Marta Morado-Arias, D. Layton, Koichi Onodera, M. Verhovsek, W. Barcellini, S. Chonat, M. Judge, E. Zagadailov, Rengyi Xu, P. Hawkins, V. Beynon, S. Gheuens, E. V. van Beers   +18 more
semanticscholar   +1 more source

Pyruvate kinase phosphatase [PDF]

FEBS Letters, 1981
1. Introduction Liver pyruvate kinase can be phosphorylated and simultaneously inactivated by CAMP-dependent pro- tein kinase; the inactivated enzyme can be reactivated by a multifunctional protein phosphatase (review [ 13). The inactivation of pyruvate kinase has been observed in isolated hepatocytes incubated in the presence of glucagon and in this ...
Mary-Frances Jett, Henri-Géry Hers, Louis Hue   +2 more
openaire   +3 more sources