Results 1 to 10 of about 124,832 (334)

Pyruvate kinase activators for treatment of pyruvate kinase deficiency. [PDF]

Hematology Am Soc Hematol Educ Program, 2023
Abstract Pyruvate kinase (PK) deficiency is a congenital hemolytic anemia with wide-ranging clinical symptoms and complications associated with significant morbidity and reduced health-related quality of life in both children and adults.
Grace RF.
europepmc   +3 more sources

Pyruvate kinase directly generates GTP in glycolysis, supporting growth and contributing to guanosine toxicity [PDF]

mBio
Guanosine triphosphate (GTP) is essential for macromolecular biosynthesis, and its intracellular levels are tightly regulated in bacteria. Loss of the alarmone (p)ppGpp disrupts GTP regulation in Bacillus subtilis, causing cell death in the presence of ...
Fukang She, Kuanqing Liu, Brent W. Anderson, Tippapha Pisithkul, Yanxiu Li, Danny K. Fung, Tyler McCue, William Mulhern, Daniel Amador-Noguez, Jue D. Wang   +9 more
doaj   +2 more sources

Pyruvate kinase deficiency

Haematologica, 2007
Over the past few years the inherited disorders of erythrocyte metabolism have been the object of intensive research which has resulted in a better understanding of their molecular basis. However, curative therapy for red blood cell (RBC) enzyme defects still remains undeveloped.
Alberto Zanella, Paola Bianchi, Elisa Fermo   +2 more
doaj   +4 more sources

Allosteric regulation of pyruvate kinase enables efficient and robust gluconeogenesis by preventing metabolic conflicts and carbon overflow [PDF]

mSystems
Gluconeogenesis, the reciprocal pathway of glycolysis, is an energy-consuming process that generates glycolytic intermediates from non-carbohydrate sources. In this study, we demonstrate that robust and efficient gluconeogenesis in bacteria relies on the
Fukang She, Brent W. Anderson, Daven B. Khana, Shenwei Zhang, Wieland Steinchen, Danny K. Fung, Nathalie G. Lesser, Lauren N. Lucas, David M. Stevenson, Theresa J. Astmann, Gert Bange, Jan-Peter van Pijkeren, Daniel Amador-Noguez, Jue D. Wang   +13 more
doaj   +2 more sources

Reaction Engineering and Comparison of Electroenzymatic and Enzymatic ATP Regeneration Systems [PDF]

ChemElectroChem, 2023
Adenosine‐5’‐triphosphate (ATP) plays a crucial role in many biocatalytic reactions and its regeneration can influence the performance of a related enzymatic reaction significantly.
Regine Siedentop, Tobias Prenzel, Prof. Dr. Siegfried R. Waldvogel, Prof. Dr. Katrin Rosenthal, Prof. Dr. Stephan Lütz   +4 more
doaj   +2 more sources

Pyruvate Kinase Deficiency Causing Priapism [PDF]

Case Reports in Hematology, 2023
Pyruvate kinase deficiency (PKD) is an autosomal recessive defect of the enzyme pyruvate kinase (PK) which is involved in catalyzing a reaction that produces ATP in the glycolytic pathway. It is the most common defect of the glycolytic pathway associated
Vinay Hanyalu Shankar, Bharadwaj Adithya-Sateesh, Nicole Gousy, Girma Ayele, Freyr Petursson, Rediet Atalay, Miriam Michael   +6 more
doaj   +2 more sources

Studies on the Enolization of Pyruvate by Pyruvate Kinase [PDF]

Journal of Biological Chemistry, 1960
Irwin A. Rose
openaire   +3 more sources

Pyruvate kinase phosphatase [PDF]

FEBS Letters, 1981
1. Introduction Liver pyruvate kinase can be phosphorylated and simultaneously inactivated by CAMP-dependent pro- tein kinase; the inactivated enzyme can be reactivated by a multifunctional protein phosphatase (review [ 13). The inactivation of pyruvate kinase has been observed in isolated hepatocytes incubated in the presence of glucagon and in this ...
Mary-Frances Jett, Henri-Géry Hers, Louis Hue   +2 more
openaire   +3 more sources

A Sri Lankan girl with a new genetic variant in the PKLR gene causing pyruvate kinase deficiency: a case report

Journal of Medical Case Reports, 2021
Background Erythrocyte pyruvate kinase is expressed under the control of the PKLR gene located on chromosome 1q21. Pyruvate kinase catalyzes the final steps of the glycolytic pathway and creates 50% of the red cell total adenosine triphosphate.
Ahalyaa Sivashangar, Lallindra Gooneratne, Barnaby Clark, David Rees, Saroj Jayasinghe, Claire Laas   +5 more
doaj   +1 more source

Ethyl pyruvate protects SHSY5Y cells against 6-hydroxydopamine-induced neurotoxicity by upregulating autophagy

PLoS ONE, 2023
Parkinson disease is a chronic progressive neurodegenerative disorder with a prevalence that increases with age. The glycolytic end-product pyruvate, has antioxidant and neuroprotective feature. Here, we investigated the effects of ethyl pyruvate (EP), a
Yuening Luo, Kazuichi Sakamoto
doaj   +2 more sources