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Pyruvate kinase activators for treatment of pyruvate kinase deficiency. [PDF]

Hematology Am Soc Hematol Educ Program, 2023
Pyruvate kinase (PK) deficiency is a congenital hemolytic anemia with wide-ranging clinical symptoms and complications associated with significant morbidity and reduced health-related quality of life in both children and adults.
Grace RF.
europepmc   +4 more sources

Pyruvate kinase deficiency [PDF]

Haematologica, 2007
Over the past few years the inherited disorders of erythrocyte metabolism have been the object of intensive research which has resulted in a better understanding of their molecular basis.
Alberto Zanella, Paola Bianchi, Elisa Fermo   +2 more
doaj   +7 more sources

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis

Frontiers in Oncology, 2020
Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is catalyzed by Pyruvate Kinase. There are four isomeric, tissue-specific
Kulsoom Zahra, Tulika Dey, Ashish, Surendra Pratap Mishra, Uma Pandey   +4 more
doaj   +2 more sources

Protein kinase function of pyruvate kinase M2 and cancer

Cancer Cell International, 2020
Pyruvate kinase is a terminal enzyme in the glycolytic pathway, where it catalyzes the conversion of phosphoenolpyruvate to pyruvate and production of ATP via substrate level phosphorylation.
Xun Chen, Shangwu Chen, Dongsheng Yu
doaj   +2 more sources

Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase [PDF]

J Theor Biol 240: 464-474 (2006), 2005
Integrating biological information from different sources to understand cellular processes is an important problem in systems biology. We use data from mRNA expression arrays and chemical kinetics to formulate a metabolic model relevant to K562 erythroleukemia cells. MAP kinase pathway activation alters the expression of metabolic enzymes in K562 cells.
Akesson, Baker, Barkai, Borgmann, Dang, Fan, Ferea, Goodacre, Griffiths, Gross, Joel R. Sevinsky, Joshua Downer, Jungmann, Kal, Karan, Katheryn A. Resing, Kim, Kitano, Kondoh, Koslowski, Koukourakis, Lambeth, Lewis, Lewis, Li, M.D. Betterton, Maekawa, Mazurek, Mulquiney, Munoz-Pinedo, Natalie G. Ahn, Newell, Osthus, Papas, Press, Riera, Segal, Sevinsky, Shim, Stambaugh, Stephanopoulos, Stubbs, Tilton, Unwin, Voet, von Dassow, Walenta, Warburg   +47 more
arxiv   +3 more sources

Pyruvate Kinase Deficiency Causing Priapism [PDF]

Case Reports in Hematology, 2023
Pyruvate kinase deficiency (PKD) is an autosomal recessive defect of the enzyme pyruvate kinase (PK) which is involved in catalyzing a reaction that produces ATP in the glycolytic pathway. It is the most common defect of the glycolytic pathway associated
Vinay Hanyalu Shankar, Bharadwaj Adithya-Sateesh, Nicole Gousy, Girma Ayele, Freyr Petursson, Rediet Atalay, Miriam Michael   +6 more
doaj   +2 more sources

Reaction Engineering and Comparison of Electroenzymatic and Enzymatic ATP Regeneration Systems [PDF]

ChemElectroChem, 2023
Adenosine‐5’‐triphosphate (ATP) plays a crucial role in many biocatalytic reactions and its regeneration can influence the performance of a related enzymatic reaction significantly.
Regine Siedentop, Tobias Prenzel, Prof. Dr. Siegfried R. Waldvogel, Prof. Dr. Katrin Rosenthal, Prof. Dr. Stephan Lütz   +4 more
doaj   +2 more sources

Defective Erythrocyte Pyruvate Kinase with Impaired Kinetics and Reduced Optimal Activity [PDF]

, 1972
A unique mutant form of erythrocyte pyruvate kinase has been found associated with chronic haemolytic anaemia in a child who is apparently doubly heterozygous for the mutant isoenzyme and for pyruvate kinase deficiency of the classical quantitative type.
Baughan M.A., Boivin P., Borvnsr P., Bucher T., Koutras G.A., Krimsky I., Mentzer W., Minakami S., Ohyama H., Paglia D.E., Paglia D.E., Paglia D.E., Schneider A.S., Selwyn J.G., Tanaka K.R., Tanaka K.R., Tanaka K.R., Valentine W.N., Valentine W.N., Valentine W.N., Valentine W.N., Waller H.D., Zuelzer W.W.   +22 more
core   +2 more sources

Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells

Cancer & Metabolism, 2019
Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options. Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in PDAC cells, but its role in pancreatic cancer remains controversial.
Lei Yu, Shao Thing Teoh, Elliot Ensink, Martin P. Ogrodzinski, Che Yang, Ana I. Vazquez, Sophia Y. Lunt   +6 more
doaj   +2 more sources

Studies on the Enolization of Pyruvate by Pyruvate Kinase [PDF]

Journal of Biological Chemistry, 1960
Irwin A. Rose
openalex   +3 more sources