Results 11 to 20 of about 1,119,388 (379)
Mitapivat, a novel pyruvate kinase activator, for the treatment of hereditary hemolytic anemias
Therapeutic Advances in Hematology, 2021 Mitapivat (AG-348) is a novel, first-in-class oral small molecule allosteric activator of the pyruvate kinase enzyme. Mitapivat has been shown to significantly upregulate both wild-type and numerous mutant forms of erythrocyte pyruvate kinase (PKR ...
Hanny Al‐Samkari, E. V. van Beers
semanticscholar +1 more source
Journal of Medical Case Reports, 2021 Background Erythrocyte pyruvate kinase is expressed under the control of the PKLR gene located on chromosome 1q21. Pyruvate kinase catalyzes the final steps of the glycolytic pathway and creates 50% of the red cell total adenosine triphosphate.
Ahalyaa Sivashangar +5 more
doaj +1 more source
Pyruvate kinase controls signal strength in the insulin secretory pathway
bioRxiv, 2020 Pancreatic β-cells couple nutrient metabolism with appropriate insulin secretion. Here, we show that pyruvate kinase (PK), which converts ADP and phosphoenolpyruvate (PEP) into ATP and pyruvate, underlies β-cell sensing of both glycolytic and ...
Sophie L. Lewandowski +15 more
semanticscholar +1 more source
PLoS ONE, 2023 Parkinson disease is a chronic progressive neurodegenerative disorder with a prevalence that increases with age. The glycolytic end-product pyruvate, has antioxidant and neuroprotective feature. Here, we investigated the effects of ethyl pyruvate (EP), a
Yuening Luo, Kazuichi Sakamoto
doaj +2 more sources
Technology in Cancer Research & Treatment, 2020 Warburg effect describes the abnormal energy metabolism in cancer cells and pyruvate kinase type M2 is involved in the regulation of this effect.
Penglong Zhao MBBS +3 more
doaj +1 more source
Crystal structure of Cryptosporidium parvum pyruvate kinase. [PDF]
PLoS ONE, 2012 Pyruvate kinase plays a critical role in cellular metabolism of glucose by serving as a major regulator of glycolysis. This tetrameric enzyme is allosterically regulated by different effector molecules, mainly phosphosugars.
William J Cook +3 more
doaj +1 more source
Management of Pyruvate Kinase Deficiency in Children and Adults.
Blood, 2020 Pyruvate Kinase Deficiency (PKD) is an autosomal recessive enzyme defect of the glycolytic pathway that causes congenital, non-spherocytic hemolytic anemia.
R. Grace, W. Barcellini
semanticscholar +1 more source
From meadows to milk to mucosa – adaptation of Streptococcus and Lactococcus species to their nutritional environments [PDF]
, 2011 Lactic acid bacteria (LAB) are indigenous to food-related habitats as well as associated with the mucosal surfaces of animals. The LAB family Streptococcaceae consists of the genera Lactococcus and Streptococcus.
Adab, P. +12 more
core +8 more sources
Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts. [PDF]
, 2019 Pancreatic cancer is a complex disease, in need of new therapeutic approaches. In this study, we explored the effect and mechanism of action of epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, alone and in combination with current ...
Hackman, Robert M +3 more
core +1 more source
Plants, 2020 Glycolysis is a central catabolic pathway in every living organism with an essential role in carbohydrate breakdown and ATP synthesis, thereby providing pyruvate to the tricarboxylic acid cycle (TCA cycle).
Sabine Wulfert +2 more
doaj +1 more source