Results 11 to 20 of about 124,832 (334)
Inferring Compensatory Kinase Networks in Yeast using Prolog [PDF]
EPTCS 385, 2023, pp. 260-273, 2023 Signalling pathways are conserved across different species, therefore making yeast a model organism to study these via disruption of kinase activity. Yeast has 159 genes that encode protein kinases and phosphatases, and 136 of these have counterparts in humans.
arxiv +1 more source
LIGHT-SABRE hyperpolarizes 1-^{13}C-pyruvate continuously, without magnetic field cycling [PDF]
J. Phys. Chem. C 2023, 127, 14, 6744-6753, 2023 Nuclear spin hyperpolarization enables real-time observation of metabolism and intermolecular interactions in vivo. 1-13C-Pyruvate is the leading hyperpolarized tracer currently under evaluation in several clinical trials as a promising molecular imaging agent.
arxiv +1 more source
Technology in Cancer Research & Treatment, 2020 Warburg effect describes the abnormal energy metabolism in cancer cells and pyruvate kinase type M2 is involved in the regulation of this effect.
Penglong Zhao MBBS +3 more
doaj +1 more source
Protein kinase function of pyruvate kinase M2 and cancer
Cancer Cell International, 2020 Pyruvate kinase is a terminal enzyme in the glycolytic pathway, where it catalyzes the conversion of phosphoenolpyruvate to pyruvate and production of ATP via substrate level phosphorylation.
Xun Chen, Shangwu Chen, Dongsheng Yu
doaj +1 more source
Crystal structure of Cryptosporidium parvum pyruvate kinase. [PDF]
PLoS ONE, 2012 Pyruvate kinase plays a critical role in cellular metabolism of glucose by serving as a major regulator of glycolysis. This tetrameric enzyme is allosterically regulated by different effector molecules, mainly phosphosugars.
William J Cook +3 more
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Plants, 2020 Glycolysis is a central catabolic pathway in every living organism with an essential role in carbohydrate breakdown and ATP synthesis, thereby providing pyruvate to the tricarboxylic acid cycle (TCA cycle).
Sabine Wulfert +2 more
doaj +1 more source
Rapid inhibition of pyruvate dehydrogenase: an initiating event in high dietary fat-induced loss of metabolic flexibility in the heart. [PDF]
PLoS ONE, 2013 Cardiac function depends on the ability to switch between fatty acid and glucose oxidation for energy production in response to changes in substrate availability and energetic stress.
Clair Crewe +2 more
doaj +1 more source
Frontiers in Physiology, 2020 A metabolic hallmark of many cancers is the increase in glucose consumption coupled to excessive lactate production. Mindful that L-lactate originates only from pyruvate, the question arises as to how can this be sustained in those tissues where pyruvate
Christos Chinopoulos
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A monomeric form of pyruvate kinase in human pyruvate kinase deficiency. [PDF]
Proceedings of the National Academy of Sciences, 1977 A mutant pyruvate kinase (ATP:pyruvate 2-O-phosphotransferase, EC 2.7.1.40) from human erythrocytes which is easily separated into monomers and dimers by gel chromatography is described. Tht mutant enzyme shows almost the same pH optimum and thermostability as normal enzyme, but has a decreased stability on shaking with air, a decreased Km for ...
Toshio Asakura +3 more
openaire +3 more sources
Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis
Frontiers in Oncology, 2020 Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is catalyzed by Pyruvate Kinase. There are four isomeric, tissue-specific
Kulsoom Zahra +4 more
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