Pyruvate Kinase Deficiency Causing Priapism
Case Reports in Hematology, 2023 Pyruvate kinase deficiency (PKD) is an autosomal recessive defect of the enzyme pyruvate kinase (PK) which is involved in catalyzing a reaction that produces ATP in the glycolytic pathway. It is the most common defect of the glycolytic pathway associated
Vinay Hanyalu Shankar +6 more
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Proteomic study of the membrane components of signalling cascades of Botrytis cinerea controlled by phosphorylation [PDF]
, 2019 Protein phosphorylation and membrane proteins play an important role in the infection of plants by phytopathogenic fungi, given their involvement in signal transduction cascades.
Amil, Francisco +9 more
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Global Gene Expression Profiling of Individual Human Oocytes and Embryos Demonstrates Heterogeneity in Early Development [PDF]
, 2013 Early development in humans is characterised by low and variable embryonic viability, reflected in low fecundity and high rates of miscarriage, relative to other mammals.
Brison, Daniel R. +4 more
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Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis
Frontiers in Oncology, 2020 Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is catalyzed by Pyruvate Kinase. There are four isomeric, tissue-specific
Kulsoom Zahra +4 more
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The contribution of two isozymes to the pyruvate kinase activity of Vibrio cholerae: One K+-dependent constitutively active and another K+-independent with essential allosteric activation. [PDF]
PLoS ONE, 2017 In a previous phylogenetic study of the family of pyruvate kinase EC (2.7.1.40), a cluster with Glu117 and another with Lys117 were found (numbered according to the rabbit muscle enzyme).
Carlos Guerrero-Mendiola +4 more
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Specificity of pyruvate kinase [PDF]
Biochimica et Biophysica Acta, 1959 Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/32459/1/0000543 ...
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A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation [PDF]
, 2019 Regulation of the energetic metabolism occurs fundamentally at the cellular level, so analytical strategies must aim to attain single cell resolution to fully embrace its inherent complexity.
Behrensen, C. +3 more
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Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]
, 2011 Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Alexei Vazquez +2 more
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Hydrops fetalis associated with erythrocyte pyruvate kinase deficiency [PDF]
, 2000 The authors report a case of hydrops fetalis due to severe pyruvate kinase deficiency, the most unusual clinical manifestation of this disease. Conclusion Pyruvate kinase deficiency, as other erythrocyte enzymopathies, must be considered in the ...
Araújo, Filomena +8 more
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Research Progress on the Effect of Post-translational Modification of Pyruvate Kinase on Meat Quality [PDF]
Shipin KexueThe postmortem conversion of muscle to meat goes through a series of complex physiological and biochemical changes, among which protein post-translational modifications (PTMs) are key factors affecting meat quality.
HUANG Xiaolan, CHEN Li, REN Chi, BAI Yuqiang, HOU Chengli, LI Xin, LUO Ruiming, ZHANG Dequan
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