Results 21 to 30 of about 128,438 (311)

Pyruvate Kinase Revisited [PDF]

Journal of Biological Chemistry, 2005
Desde hace más de 50 años, se sabe que el K+ es un activador esencial de la piruvato quinasa (Kachmar, J. F., y Boyer, P. D. (1953) J. Biol. Chem. 200, 669-683). Sin embargo, el papel de K+ en la catálisis por piruvato quinasa no se ha entendido completamente.
Jesús Oria‐Hernández, Nallely Cabrera, Ruy Pérez‐Montfort, Leticia Ramírez‐Silva   +3 more
openaire   +3 more sources

Specific tumor-derived CCL2 mediated by pyruvate kinase M2 in colorectal cancer cells contributes to macrophage recruitment in tumor microenvironment

Tumor Biology, 2017
Development of colorectal cancer has been considered as a result of imbalance of pro- and anti-inflammatory intestinal microenvironment accompanied by macrophage recruitment.
Kejian Zou, Yaodong Wang, Yan Hu, Liansheng Zheng, Wanfu Xu, Guoxin Li   +5 more
doaj   +1 more source

Research Progress on the Effect of Post-translational Modification of Pyruvate Kinase on Meat Quality [PDF]

Shipin Kexue
The postmortem conversion of muscle to meat goes through a series of complex physiological and biochemical changes, among which protein post-translational modifications (PTMs) are key factors affecting meat quality.
HUANG Xiaolan, CHEN Li, REN Chi, BAI Yuqiang, HOU Chengli, LI Xin, LUO Ruiming, ZHANG Dequan
doaj   +1 more source

A novel homozygous missense variant p.D339N in the PKLR gene correlates with pyruvate kinase deficiency in a Pakistani family: a case report

Journal of Medical Case Reports, 2022
Background Pyruvate kinase deficiency is an exceptionally rare autosomal recessive Mendelian disorder caused by bi-allelic pathogenic variants in the PKLR gene.
Atta Ur Rehman, Abdur Rashid, Zubair Hussain, Khadim Shah   +3 more
doaj   +1 more source

Characterizing the Effect of the Lysine Deacetylation Modification on Enzyme Activity of Pyruvate Kinase I and Pathogenicity of Vibrio alginolyticus

Frontiers in Veterinary Science, 2022
Pyruvate kinase I (PykF) is one of the key enzymes of glycolysis and plays a crucial role in bacterial metabolism. Several acetylation sites of Vibrio alginolyticus PykF were reported in previous studies and then 11 sites were first verified in this ...
Zhou Xu, Zhou Xu, Zhou Xu, Linjing Wang, Linjing Wang, Linjing Wang, Xudong Wang, Xudong Wang, Xudong Wang, Mingyue Wan, Mingyue Wan, Mingyue Wan, Mei Tang, Mei Tang, Mei Tang, Yu Ding, Yu Ding, Yu Ding   +17 more
doaj   +1 more source

Specificity of pyruvate kinase [PDF]

Biochimica et Biophysica Acta, 1959
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/32459/1/0000543 ...
openaire   +4 more sources

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase [PDF]

Diabetes & Metabolism Journal, 2012
The pyruvate dehydrogenase complex (PDC) activity is crucial to maintains blood glucose and ATP levels, which largely depends on the phosphorylation status by pyruvate dehydrogenase kinase (PDK) isoenzymes.
Ji Yun Jeong, Nam Ho Jeoung, Keun-Gyu Park, In-Kyu Lee   +3 more
doaj   +1 more source

Pyruvate Kinase, Inflammation and Periodontal Disease

Pathogens, 2021
Pyruvate kinase (PK) is the final and rate-limiting enzyme in glycolysis. It has four isoforms PKM1, PKM2, PKL and PKR. PK can form homo tetramers, dimers or monomers. The tetrameric form has the most catalytic activity; however, the dimeric form has non-
Melissa M. Grant
doaj   +1 more source

Pyruvate kinase deficiency mimicking congenital dyserythropoietic anemia type I

The Turkish Journal of Pediatrics, 2022
Background. Pyruvate kinase (PK) deficiency is the most common enzyme abnormality in the glycolytic pathway. Here, we describe two siblings with PK deficiency that mimicked congenital dyserythropoietic anemia (CDA) type I. Case.
Ayça Koca Yozgat, Arzu Yazal Erdem, Dilek Kaçar, Namık Yaşar Özbek, Neşe Yaralı   +4 more
doaj   +1 more source

Probing Conformational Feature of a Recombinant Pyruvate Kinase by Limited Proteolysis [PDF]

Journal of Sciences, Islamic Republic of Iran, 2013
Pyruvate kinase is a key enzyme in glycolytic pathway that catalyzes the transphosphorylation between phosphoenolpyruvate and ADP to yield ATP and Pyruvate.
M. Banijamali, S. Hosseinkhani, J. Fuladi   +2 more
doaj