Results 101 to 110 of about 35,351 (202)
ChemMedChem, Volume 21, Issue 5, 13 March 2026.The topoisomerase I inhibition and antiproliferative activities of phosphorated indenoquinoline derivatives were investigated. The target hybrid quinoline and tetrahydroquinoline compounds were synthesized via a two‐step Povarov‐type cycloaddition.
Alba Rodriguez +5 more
wiley +1 more source
Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)
ChemMedChem, Volume 21, Issue 5, 13 March 2026.DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley +1 more source
A Nitroreductase‐Activatable Lapachol Against Bacillus subtilis Unveils Antimicrobial Specificity
ChemMedChem, Volume 21, Issue 5, 13 March 2026.A nitroreductase‐activatable lapachol prodrug overcomes toxicity to mammalian cells b selectively releases the antimicrobial natural product only in bacteria, addressing antimicrobial resistance. Enzymatic reduction in Bacillus subtilis triggers self‐immolative uncaging to restore antibacterial activity while sparing healthy cells.
Ivonne R. Lopez‐Miranda +3 more
wiley +1 more source
Beyond Cocrystals: Hierarchical Functional Assemblies via Noncovalent Synthesis
Advanced Science, Volume 13, Issue 13, 3 March 2026.Non‐covalent interactions (NCIs) drive the formation of organic cocrystals with diverse structures and tunable optoelectronic properties. This review explores the essential factors governing these properties, highlighting how the sequential nucleation of cocrystals leads to the self‐assembly of organic hierarchical structures (OHSs).
Ya‐Nan Zhu +6 more
wiley +1 more source
Aggregate, Volume 7, Issue 3, March 2026.The multi‐component doping strategy, involving self‐assembly, host‐guest systems, and crystal engineering, has gained attention for its simplicity, cost‐effectiveness, structural diversity, and adjustable room‐temperature phosphorescence (RTP). This review summarizes and evaluates the progress in creating RTP materials using this strategy, highlighting
Zhenjie Zhou +10 more
wiley +1 more source
ChemistryEurope, Volume 4, Issue 3, March 2026.A tetracarbonyl tungsten complex bearing a bis‐triazolylidene ligand exhibits excellent catalytic activity in the acceptorless dehydrogenative coupling of 1‐phenylethanol and 2‐aminobenzyl alcohol to form 2‐phenylquinoline with H2 evolution. Mechanistic investigations combining experimental and DFT studies reveal the unprecedented base‐promoted ...
Beatriz Garcia +2 more
wiley +1 more source
Food Frontiers, Volume 7, Issue 2, March 2026.ABSTRACT Medicago sativa L. (alfalfa) harbors a remarkably diverse reservoir of bioactive secondary metabolites. Flavonoids, isoflavones, and triterpenoid saponins dominate its bioactivity landscape, driving potent antioxidant, anti‐inflammatory, antimicrobial, estrogenic, hypolipidemic, and cytotoxic actions through redox modulation, membrane ...
Parham Joolaei Ahranjani +3 more
wiley +1 more source
Stable BF2 Boracycles as Versatile Reagents for Selective Ortho C–H Functionalization
Angewandte Chemie, Volume 138, Issue 8, 16 February 2026.We report a robust, metal‐free and scalable synthesis of stable BF2 boracycles via directed ortho CH borylation, delivering isolable, shelf‐stable reagents without chromatographic purification. These BF2 boracycles exhibit unique and tunable reactivity, enabling highly selective ipso‐functionalization across a broad range of transformations.
Ganesh H. Shinde +11 more
wiley +2 more sources
Ximenia americana L. From Popular Use to Anti‐Inflammatory Activities: A Comprehensive Review
Food Frontiers, Volume 7, Issue 2, March 2026.ABSTRACT Ximenia americana (L.), known as “yellow plum,” “sea lemon,” or “Brazilian plum,” is a tropical/subtropical plant widely used in traditional medicine. Its roots, leaves, flowers, stem, and fruits are traditionally employed to treat various inflammatory disorders.
Bruno Anderson F. Silva +9 more
wiley +1 more source
MedComm, Volume 7, Issue 3, March 2026.In normal cells, FBXW7 promotes ubiquitylation and degradation of SPT6 and ΔNp63 to keep their pro‐proliferative functions under control. During esophageal tumorigenesis, FBXW7 is inactivated by mutations or deletion, leading to the accumulation of SPT6 and ΔNp63, with ΔNp63 also being up‐regulated by SPT6.
Jiagui Zhang +4 more
wiley +1 more source