Results 11 to 20 of about 9,953 (212)

Quinoxaline Moiety: A Potential Scaffold against Mycobacterium tuberculosis

Molecules, 2021
Background. The past decades have seen numerous efforts to develop new antitubercular agents. Currently, the available regimens are lengthy, only partially effective, and associated with high rates of adverse events. The challenge is therefore to develop
Marc Montana, Vincent Montero, Omar Khoumeri, Patrice Vanelle   +3 more
doaj   +1 more source

Analgesic and anti-inflammatory activity of quinoxaline derivatives: Design synthesis and characterization

Results in Chemistry, 2023
Medicinal chemistry is a basic science that involves identification, synthesis and development of new drugs for therapeutic use. Biological importance of heterocycles makes them more crucial in pharmaceutical industries.In this work heterocyclics like ...
Geethavani Meka, Ramakrishna Chintakunta
doaj   +1 more source

Push–Pull Derivatives Based on 2,4′-Biphenylene Linker with Quinoxaline, [1,2,5]Oxadiazolo[3,4-B]Pyrazine and [1,2,5]Thiadiazolo[3,4-B]Pyrazine Electron Withdrawing Parts

Molecules, 2022
A series of novel V-shaped quinoxaline, [1,2,5]oxadiazolo[3,4-b]pyrazine and [1,2,5]thiadiazolo[3,4-b]pyrazine push–pull derivatives with 2,4′-biphenylene linker were designed and their electrochemical, photophysical and nonlinear optical properties were
Egor V. Verbitskiy, Pascal le Poul, Filip Bureš, Sylvain Achelle, Alberto Barsella, Yuriy A. Kvashnin, Gennady L. Rusinov, Valery N. Charushin   +7 more
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Synthesis, characterization, and biological target prediction of novel 1,3-dithiolo[4,5-b]quinoxaline and thiazolo[4,5-b]quinoxaline derivatives

Heterocyclic Communications, 2023
Quinoxalines are a family of nitrogen-based heterocyclic compounds that have garnered much interest because of their wide range of applications. 2,3-Dichloroquinoxaline is an aromatic molecule that frequently serves as a synthetic intermediate in ...
El-Gaby Mohamed S. A., Ammar Yousry A., Ismail Mostafa A., Ragab Ahmed, Abusaif Moustafa S.   +4 more
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Chemistry, Synthesis, and Structure Activity Relationship of Anticancer Quinoxalines

Chemistry, 2023
Quinoxaline is a fused heterocycle system of a benzene ring and pyrazine ring. It has earned considerable attention due to its importance in the field of medicinal chemistry.
Mohamed F. Zayed
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Alkoxyallene‐Based LANCA Three‐Component Synthesis of 1,2‐Diketones, Quinoxalines, and Unique Isoindenone Dimers and a Computational Study of the Isoindenone Dimerization [PDF]

, 2020
A series of β‐alkoxy‐β‐ketoenamides was prepared by the well‐established LANCA three‐component reaction of lithiated 1‐(2‐trimethylsilylethoxy)‐substituted allenes, nitriles, and α,β‐unsaturated carboxylic acids.
Bera M. K., Holland J. M., Lechel T., Lechel T., Zimmer R., Zimmer R., Zimmer R.   +6 more
core   +1 more source

Recent Updates on the Synthesis of Bioactive Quinoxaline-Containing Sulfonamides

Applied Sciences, 2021
Quinoxaline is a privileged pharmacophore that has broad-spectrum applications in the fields of medicine, pharmacology and pharmaceutics. Similarly, the sulfonamide moiety is of considerable interest in medicinal chemistry, as it exhibits a wide range of
Ali Irfan, Sajjad Ahmad, Saddam Hussain, Fozia Batool, Haseeba Riaz, Rehman Zafar, Katarzyna Kotwica-Mojzych, Mariusz Mojzych   +7 more
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Induction of Cell Death in Human A549 Cells Using 3-(Quinoxaline-3-yl) Prop-2-ynyl Methanosulphonate and 3-(Quinoxaline-3-yl) Prop-2-yn-1-ol

Molecules, 2019
Despite major advancements in the development of various chemotherapeutic agents, treatment for lung cancer remains costly, ineffective, toxic to normal non-cancerous cells, and still hampered by a high level of remissions.
Mixo Aunny Sibiya, Lerato Raphoko, Dikgale Mangokoana, Raymond Makola, Winston Nxumalo, Thabe Moses Matsebatlela   +5 more
doaj   +1 more source

Electrochemical behavior of indolone-N-oxides: Relationship to structure and antiplasmodial activity [PDF]

, 2012
Indolone-N-oxides exert high parasiticidal activity at the nanomolar level in vitro against Plasmodiumfalciparum, the parasite responsible for malaria.
Fabre, Paul-Louis, Ibrahim, Hany, Montrose, Armelle, Nepveu, Françoise, Nguyen, Thi Hoang Yen, Perio, Pierre, Reybier, Karine   +6 more
core   +3 more sources

Cinnamil- and Quinoxaline-Derivative Indicator Dyes for Detecting Volatile Amines in Fish Spoilage

Molecules, 2019
Colorimetric indicators are versatile for applications such as intelligent packaging. By interacting with food, package headspace, and/or the ambient environment, color change in these indicators can be useful for reflecting the actual quality and/or ...
Xiaoyu Luo, Loong-Tak Lim
doaj   +1 more source