Results 21 to 30 of about 3,612 (183)

Microwave assisted synthesis of quinoxaline derivatives

Results in Chemistry, 2023
Substituted quinoxalines are known building blocks for compounds with pharmacological, agricultural, and material uses. Forming carbon-heteroatom bonds at the 2,3-positions on quinoxaline can be challenging. 2,3-chloroquinoxaline can undergo nucleophilic aromatic substitution however it must be in the presence of metal catalysts.
Lucas K. Beagle, Eric Horsting, Jacob Buechele, Judit K. Beagle   +3 more
openaire   +2 more sources

Synthesis, Biological Evaluation and Structure-Activity Relationships of New Quinoxaline Derivatives as Anti-Plasmodium falciparum Agents

Molecules, 2014
We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains.
Ana Gil, Adriana Pabón, Silvia Galiano, Asunción Burguete, Silvia Pérez-Silanes, Eric Deharo, Antonio Monge, Ignacio Aldana   +7 more
doaj   +1 more source

Antimicrobial Evaluation and Synthesis of Some Phenylpyrazolo benzothiazolo quinoxaline Derivatives

E-Journal of Chemistry, 2009
2,3-Diphenyl quinoxaline (SI) was fused with 2-amino benzothiazoles (SII) by a methylene bridge, which was then allowed for acetylation. The acetylated product (SIV) was made to react with different aromatic aldehydes to give chalcones (SV1-SV5 ...
CH. Sridevi, K. Balaji, A. Naidu, R. Sudhakaran   +3 more
doaj   +1 more source

Reduction Potential Predictions for Thirty-Seven 1,4-di-N-Oxide Quinoxaline-2-Carboxamide Derivatives with Anti-Tuberculosis Activity

Compounds, 2023
The ability for density functional theory with the B3LYP functional with the lanl2dz basis set to predict the 1st (Wave 1) and 2nd (Wave 2) reductions of the diazine ring in a series of thirty-seven (37) 1,4-di-N-oxide quinoxaline-2-carboxamide ...
Faranak Pooladian, Philip W. Crawford, Jonathan M. Kessler, Garrett R. Casey, Christina M. Ragain   +4 more
doaj   +1 more source

Quinoxaline 1,4-Dioxides: Advances in Chemistry and Chemotherapeutic Drug Development

Pharmaceuticals, 2023
N-Oxides of heterocyclic compounds are the focus of medical chemistry due to their diverse biological properties. The high reactivity and tendency to undergo various rearrangements have piqued the interest of synthetic chemists in heterocycles with N ...
Galina I. Buravchenko, Andrey E. Shchekotikhin   +1 more
doaj   +1 more source

Improved Computational Prediction of the Electrochemical Reduction Potential of Twenty 3-Aryl-Quinoxaline-2-Carbonitrile 1,4-Di-N-Oxide Derivatives

Computation, 2023
The ability of density functional theory (DFT) using the functional B3LYP with the cc-pVTZ basis set to accurately predict the electrochemical properties of 20 3-aryl-quinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives in dimethylformamide (DMF) was ...
Shambhu Bhattarai, Pradeep Mareta, Philip W. Crawford, Jonathan M. Kessler, Christina M. Ragain   +4 more
doaj   +1 more source

Synthesis of Some Phenylpyrazolo Benzimidazolo Quinoxaline Derivatives as Potent Antihistaminic Agents

E-Journal of Chemistry, 2010
2,3-Diphenyl quinoxaline (NI) was fused with benzimidazole (NII) by a methylene bridge, which was then allowed for acetylation. The acetylated product (NIV) was made to react with different aromatic aldehydes to give chalcones (NV1-NV5).
C. H. Sridevi, K. Balaji, A. Naidu, R. Sudhakaran   +3 more
doaj   +1 more source

Synthesis and Reactions of Quinoxaline Derivatives [PDF]

Bulletin of the Chemical Society of Japan, 1984
Abstract Reaction of 3-methyl-2(1H)quinoxalinone (1) with alkyl, benzyl, and arenesulfonyl halides in the presence of K2CO3 in dry acetone gave 1-substituted 3-methyl-2(1H)-quinoxalinones (2a–g). However 1 reacts with benzoyl chloride under the same conditions to give 3-methyl-2-quinoxalinyl benzoate, while it reacts with P2S5 in dry ...
Mahmoud Zarif Amin Badr, Galal Moustafa El-Naggar, Hassan Ahmad Hassan El-Sherief, Safar Ahmed Mahgoub   +3 more
openaire   +1 more source

Synthesis of quinoxaline 1,4-di-N-oxide derivatives on solid support using room temperature and microwave-assisted solvent-free procedures

Química Nova, 2011
We describe the synthesis of 12 new ethyl and methyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives on solid supports with room temperature and microwave-assisted solvent-free procedures.
Lilia C Gómez-Caro, Mario Sánchez-Sánchez, Virgilio Bocanegra-García, Gildardo Rivera, Antonio Monge   +4 more
doaj   +1 more source

Bromination of quinoxaline and derivatives: Effective synthesis of some new brominated quinoxalines

Tetrahedron, 2017
Abstract The synthesis of brominated quinoxaline derivatives starting from several kinds of quinoxaline by different bromination strategies was studied. First the synthesis of some brominated quinoxalines was accomplished along with the development of an alternative and effective synthesis of some known compounds.
Ucar, Sefa, Essiz, Selcuk, Dastan, Arif
openaire   +4 more sources