Results 91 to 100 of about 25,169 (206)

Crystal structures of Fsc1, a novel autophagy factor that mediates autophagosome–vacuole fusion in fission yeast

Acta Crystallographica Section D, Volume 82, Issue 4, Page 358-369, April 2026.
Crystal structures of the autophagy protein Fsc1 reveal conserved fasciclin features and a stable dimer interface that illuminate its possible role as a scaffold in autophagosome–vacuole membrane fusion.Fsc1 is a recently identified autophagy factor in the fission yeast Schizosaccharomyces pombe that is implicated in the autophagosome–vacuole fusion ...
Chidiogo Azuka, Jian Liu, Xiangshu Jin
wiley   +1 more source

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. [PDF]

, 2012
Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease.
Bardy, Cedric, Boscolo, Francesca S, Carson, Christian T, Gage, Fred H, Goldstein, Lawrence SB, Hefferan, Michael P, Herrera, Cheryl, Israel, Mason A, Koo, Edward H, Laurent, Louise C, Marsala, Martin, Mu, Yangling, Nazor, Kristopher L, Remes, Anne M, Reyna, Sol M, Van Gorp, Sebastiaan, Yuan, Shauna H   +16 more
core   +3 more sources

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, Volume 183, Issue 7, Page 1578-1601, April 2026.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour [PDF]

, 2016
The five-subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in
Insall, Robert H., Machesky, Laura M., Spence, Heather J., Strathdee, Douglas, Tyrrell, Benjamin J., Woodham, Emma F.   +5 more
core   +1 more source

Entanglement of plant immunity and endomembrane trafficking revealed by plant–powdery mildew fungal interactions

New Phytologist, Volume 250, Issue 2, Page 799-804, April 2026.
Summary Plant immunity is complex, and studies of leaf epidermal cells attacked by powdery mildew fungi have been instrumental in revealing how it relies on plant endomembrane trafficking. Immunity against these biotrophic fungi is manifested as cell wall deposits (‘papillae’) and the hypersensitive reaction (HR), both involving plant endomembrane ...
Hans Thordal‐Christensen, João Paulo Alves Plácido, Sohini Deb, Mads E. Nielsen   +3 more
wiley   +1 more source

Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation

eLife
The spatiotemporal transition of small GTPase Rab5 to Rab7 is crucial for early-to-late endosome maturation, yet the precise mechanism governing Rab5-to-Rab7 switching remains elusive.
Yue Miao, Yongtao Du, Baolei Wang, Jingjing Liang, Yu Liang, Song Dang, Jiahao Liu, Dong Li, Kangmin He, Mei Ding   +9 more
doaj   +1 more source

TUFT1 promotes metastasis and chemoresistance in triple negative breast cancer through the TUFT1/Rab5/Rac1 pathway

Cancer Cell International, 2019
Background Triple negative breast cancer (TNBC) is a breast cancer (BC) subtype that is characterized by its strong invasion and a high risk of metastasis. However, the specific mechanisms underlying these phenotypes are unclear. TUFT1 plays an important
Weiguang Liu, Jianjun Han, Sufang Shi, Yuna Dai, Jianchao He   +4 more
doaj   +1 more source

FgVps9, a Rab5 GEF, Is Critical for DON Biosynthesis and Pathogenicity in Fusarium graminearum

Frontiers in Microbiology, 2020
Rab GTPases play an important role in vesicle-mediated membrane trafficking in eukaryotes. Previous studies have demonstrated that deletion of RAB5/VPS21 reduces endocytosis and virulence of fungal phytopathogens in their host plants.
Chengdong Yang, Chengdong Yang, Jingjing Li, Jingjing Li, Xin Chen, Xin Chen, Xingzhi Zhang, Xingzhi Zhang, Danhua Liao, Danhua Liao, Yingzi Yun, Wenhui Zheng, Yakubu Saddeeq Abubakar, Guangpu Li, Zonghua Wang, Zonghua Wang, Zonghua Wang, Jie Zhou, Jie Zhou   +18 more
doaj   +1 more source

The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein-coupled receptor lysosomal sorting. [PDF]

, 2015
The sorting of G protein-coupled receptors (GPCRs) to lysosomes is critical for proper signaling and cellular responses. We previously showed that the adaptor protein ALIX regulates lysosomal degradation of protease-activated receptor-1 (PAR1), a GPCR ...
Dores, Michael R, J Grimsey, Neil, Lin, Huilan, Mendez, Francisco, Trejo, JoAnn   +4 more
core   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, Volume 38, Issue 17, 20 March 2026.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source