Results 31 to 40 of about 25,169 (206)
Frontiers in Cellular Neuroscience, 2018 Neurotrophin receptors use endosomal pathways for signaling in neurons. However, how neurotrophins regulate the endosomal system for proper signaling is unknown.
Guillermo Moya-Alvarado +3 more
doaj +1 more source
Electron tomography of late stages of FcRn-mediated antibody transcytosis in neonatal rat small intestine [PDF]
, 2012 The neonatal Fc receptor (FcRn) transports maternal immunoglobulin (IgG) across epithelia to confer passive immunity to mammalian young. In newborn rodents, FcRn transcytoses IgG from ingested milk across the intestinal epithelium for release into the ...
Bjorkman, Pamela J. +2 more
core +2 more sources
Co‐operative regulation of endocytosis by three RAB5 isoforms [PDF]
FEBS Letters, 1995 Rab proteins are small GTPases involved in the regulation of membrane traffic. Rab5a has been shown to regulate transport in the early endocytic pathway. Here we report the isolation of cDNA clones encoding two highly related isoforms, Rab5b and Rab5c. The two proteins share with Rab5a all the structural features required for regulation of endocytosis.
Bucci C +9 more
openaire +6 more sources
Rab7 associates with early endosomes to mediate sorting and transport of Semliki forest virus to late endosomes. [PDF]
PLoS Biology, 2005 Semliki forest virus (SFV) is internalized by clathrin-mediated endocytosis, and transported via early endosomes to late endosomes and lysosomes. The intracellular pathway taken by individual fluorescently labeled SFV particles was followed using ...
Andreas Vonderheit, Ari Helenius
doaj +2 more sources
Probing the druggability of membrane-bound Rab5 by molecular dynamics simulations
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 Rab5 is a small GTPase and a key regulator in early endosomal trafficking. Rab5 and its effectors are involved in a large number of infectious diseases and certain types of cancer.
Eileen Edler, Matthias Stein
doaj +1 more source
Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin
Molecular Brain, 2009 Dysfunction of alsin, particularly its putative Rab5 guanine-nucleotide-exchange factor activity, has been linked to one form of juvenile onset recessive familial amyotrophic lateral sclerosis (ALS2).
Lai Chen +5 more
doaj +1 more source
A conserved and regulated mechanism drives endosomal Rab transition
eLife, 2020 Endosomes and lysosomes harbor Rab5 and Rab7 on their surface as key proteins involved in their identity, biogenesis, and fusion. Rab activation requires a guanine nucleotide exchange factor (GEF), which is Mon1-Ccz1 for Rab7. During endosome maturation,
Lars Langemeyer +8 more
doaj +1 more source
Intrinsic tethering activity of endosomal Rab proteins. [PDF]
, 2011 Rab small G proteins control membrane trafficking events required for many processes including secretion, lipid metabolism, antigen presentation and growth factor signaling.
Brett, Christopher L +6 more
core +3 more sources
Rab5‐dependent endocytosis of KCa2.3
The FASEB Journal, 2011 We demonstrated that recycling of KCa2.3 is dependent upon Rab35/EPI64C and RME‐1. Herein, we report our initial studies on the mechanism by which KCa2.3 is retrieved from the plasma membrane. Using a biotin ligase acceptor peptide‐tagged KCa2.3 construct, we demonstrate that expression of a dominant active Rab5 (Q79L) results in the colocalization of ...
Yajuan Gao, Daniel C Devor
openaire +1 more source
Frontiers in Microbiology, 2017 Classical swine fever virus (CSFV) is a fatal pig pestivirus and causes serious financial losses to the pig industry. CSFV NS4B protein is one of the most important viral replicase proteins.
Jihui Lin +10 more
doaj +1 more source