Results 71 to 80 of about 25,169 (206)

Complex polarity: building multicellular tissues through apical membrane traffic [PDF]

, 2016
The formation of distinct subdomains of the cell surface is crucial for multicellular organism development. The most striking example of this is apical-basal polarization.
Adams, Allaire, Altschuler, Ang, Aranda, Assemat, Bai, Baker, Balda, Balklava, Bedzhov, Benton, Betschinger, Blankenship, Boehlke, Bryant, Bryant, Bryant, Bulgakova, Butty, Campbell, Cancino, Chen, Chiba, Colley, Denef, Devenport, Dhekne, Eaton, Elias, Feldman, Ferrari, Fletcher, Galvez-Santisteban, Gamblin, Gangar, Gao, Gao, Gassama-Diagne, Georgiou, Gillard, Goldstein, Grawe, Graybill, Hammer, Hao, Hariharan, Harris, Harris, Harris, Hehnly, Hehnly, Hung, Hurd, Hurov, Hutterer, Hyenne, Izumi, Izumi, Joberty, Johnson, Kemphues, Klebes, Klinkert, Klose, Krahn, Kroschewski, Kumar, Kumichel, Kusakabe, Langevin, Leibfried, Lerner, Li, Li, Li, Lin, Lin, Ling, Liu, Lock, Lu, Macara, Martin-Belmonte, McGill, Melendez, Menut, Michaux, Moberg, Morais-de-Sa, Morrison, Mrozowska, Muller, Musch, Nakayama, Nakayama, Nakayama, Neisch, Ozdamar, Parsons, Pellikka, Pinal, Plant, Pocha, Pocha, Richards, Robinson, Rodriguez-Boulan, Rodriguez-Fraticelli, Rodriguez-Fraticelli, Roeth, Roland, Rossi, Sahlender, Sakamori, Sato, Satoh, Schluter, Schottenfeld-Roames, Shafaq-Zadah, Sherrard, Shewan, Shivas, Sobajima, Sollier, Stepensky, Suzuki, Takahama, Taniguchi, Tepass, Tepass, Tepass, Thuenauer, Toro, Vaccari, Vaccari, Varelas, Vermeer, Vogel, Vogel, Vreede, Wang, Wang, Wang, Wedlich-Soldner, Wei, Wiegerinck, Willenborg, Winter, Xiong, Xiong, Yamanaka, Yamanaka, Zhang, Zhang, Zhou, Zihni, Zou   +157 more
core   +1 more source

Rab5 activation as a tumor cell migration switch [PDF]

Small GTPases, 2014
Increased cell migration is an acquired feature of metastatic cancer cells and relies on derailed signal transduction pathways. Intracellular vesicular trafficking plays a key role in cell migration due to its intricate involvement in cargo transport and membrane composition.
Pablo, Mendoza, Jorge, Díaz, Patricio, Silva, Vicente A, Torres   +3 more
openaire   +3 more sources

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks. [PDF]

, 2018
Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability.
Chen, Hongping, Choi, Eric T., Cueto, Ramon, Drosatos, Konstantinos, Fu, Hangfei, Nanayakkara, Gayani K, Park, Joon Y., Qin, Xuebin, Shao, Lijian, Shao, Ying, Sheng, Haitao, Sun, Jianxin, Sun, Yu, Wang, Hong, Wang, Luqiao, Wu, Na, Yang, Qian, Yang, William Y, Yang, Wuping, Yang, Xiaofeng, Zeng, Huihong, Zhu, Qingxian   +21 more
core   +2 more sources

Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov, Natalie Reitz, Marley Dewey, Colin L. Hisey   +3 more
wiley   +1 more source

The endocytic pathway taken by cationic substances requires Rab14 but not Rab5 and Rab7

Cell Reports, 2021
Summary: Endocytosis and endosome dynamics are controlled by proteins of the small GTPase Rab family. Besides possible recycling routes to the plasma membrane and various organelles, previously described endocytic pathways (e.g., clathrin-mediated ...
Evgeniya Trofimenko, Yuta Homma, Mitsunori Fukuda, Christian Widmann   +3 more
doaj   +1 more source

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance [PDF]

, 2017
Damaged mitochondria pose a lethal threat to cells that necessitates their prompt removal. The currently recognized mechanism for disposal of mitochondria is autophagy, where damaged organelles are marked for disposal via ubiquitylation by Parkin.
A Choudhury, A Hamacher-Brady, A Hoshino, A Kirchhofer, A Kuma, A Marchese, A Roczniak-Ferguson, A Zeigerer, AH Gaspar, C Campsteijn, C Raiborg, CH Davis, CS Zhang, D Narendra, DA Kubli, DA Kubli, DA Kubli, DC Rubinsztein, DJ Yamashiro, E Karwatowska-Prokopczuk, F Kanai, FR Maxfield, G Gong, G Twig, GL McLelland, GL McLelland, IH Lee, J Rink, JR Kremer, K Hayashida, K Hirosako, K Okatsu, KY Kim, M Komatsu, M Kundu, M Matsui, M Song, M Song, N Hariharan, NC McKnight, PA Ney, Q Sun, R Sahu, R Zoncu, RA Hanna, RN Day, S Geisler, S Hwang, S Jean, S Kaushik, S Phan, SG Roy, SJ Martin, SR Sriram, SR Yoshii, SS Lam, T Kitada, TD Cummins, TD Schmittgen, V Soubannier, WM Henne, WW Li, WX Ding, XM Liu, Y Chen, Y Nishida, Y Zhang, YR Chen   +67 more
core   +2 more sources

Amyloid‐β aggregates induce vasculopathy via ferroptosis in brain endothelial cells

Brain Pathology, EarlyView.
Blood–brain barrier (BBB) disruption is evident in brains with amyloidopathy. In this study, we demonstrate that amyloid β (Aβ) drives abnormal lipid metabolism and lipid droplet formation in brain endothelial cells, leading to lipid peroxidation and ferroptosis.
Suhyeon Son, Suji Kim, Min‐Tae Jeon, Moonseok Choi, Kyu‐Sung Kim, Suji Lee, Seung‐Yeol Nah, Do‐Geun Kim   +7 more
wiley   +1 more source

Molecular Mechanisms Used by Salmonella to Evade the Immune System [PDF]

, 2017
Human and animal pathogens are able to circumvent, at least temporarily, the sophisticated immune defenses of their hosts. Several serovars of the Gram-negative bacterium Salmonella enterica have been used as models for the study of pathogen-host ...
Bernal Bayard, Joaquín, Ramos Morales, Francisco   +1 more
core   +1 more source

Interactions of rab5 with cytosolic proteins.

Journal of Biological Chemistry, 1992
Rab proteins, one of the subfamilies of ras-like small GTP-binding proteins, are attached to cellular compartments or transport vesicles and may determine the specificity of fusion between these compartments and vesicles. It has been proposed that they alternate between a membrane-bound and a cytosolic state during their functional cycle.
Kurzchalia, Teymuras V., Gorvel, Jean-Pierre, Dupree, Paul, Parton, Robert, Kellner, Roland, Houthaeve, Tony, Gruenberg, Jean, Simons, Kai   +7 more
openaire   +2 more sources