Results 71 to 80 of about 25,588 (204)

Activation of endocytosis as an adaptation to the mammalian host by trypanosomes [PDF]

, 2007
Immune evasion in African trypanosomes is principally mediated by antigenic variation, but rapid internalization of surface-bound immune factors may contribute to survival.
Field, Mark C, Gibson, Wendy, Matthews, Keith, Natesan, Senthil Kumar A, Peacock, Lori   +4 more
core   +2 more sources

Rab5 activation as a tumor cell migration switch [PDF]

Small GTPases, 2014
Increased cell migration is an acquired feature of metastatic cancer cells and relies on derailed signal transduction pathways. Intracellular vesicular trafficking plays a key role in cell migration due to its intricate involvement in cargo transport and membrane composition.
Pablo, Mendoza, Jorge, Díaz, Patricio, Silva, Vicente A, Torres   +3 more
openaire   +3 more sources

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks. [PDF]

, 2018
Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability.
Chen, Hongping, Choi, Eric T., Cueto, Ramon, Drosatos, Konstantinos, Fu, Hangfei, Nanayakkara, Gayani K, Park, Joon Y., Qin, Xuebin, Shao, Lijian, Shao, Ying, Sheng, Haitao, Sun, Jianxin, Sun, Yu, Wang, Hong, Wang, Luqiao, Wu, Na, Yang, Qian, Yang, William Y, Yang, Wuping, Yang, Xiaofeng, Zeng, Huihong, Zhu, Qingxian   +21 more
core   +2 more sources

Infantile‐Onset Ascending Hereditary Spastic Paraplegia due to a Homozygous ALS2 Exons 24–25 Deletion: Expanding the Genotypic Spectrum

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We describe a novel homozygous intragenic deletion in the ALS2 gene in an 8‐year‐old boy with Infantile‐onset Ascending Hereditary Spastic Paraplegia (IAHSP) and oculomotor apraxia, thereby contributing to the expanding genetic landscape of ALS2‐related disorders.
Vito Luigi Colona, Maria Gnazzo, Silvia Genovese, Gessica Vasco, Lorena Travaglini, Maurizio Sabbadini, Marina Macchiaiolo, Francesco Nicita, Jacopo Sartorelli, Carmelo Piscopo, Enrico Castelli, Enrico Bertini, Andrea Bartuli, Antonio Novelli, Gessica Della Bella, Davide Vecchio   +15 more
wiley   +1 more source

The endocytic pathway taken by cationic substances requires Rab14 but not Rab5 and Rab7

Cell Reports, 2021
Summary: Endocytosis and endosome dynamics are controlled by proteins of the small GTPase Rab family. Besides possible recycling routes to the plasma membrane and various organelles, previously described endocytic pathways (e.g., clathrin-mediated ...
Evgeniya Trofimenko, Yuta Homma, Mitsunori Fukuda, Christian Widmann   +3 more
doaj   +1 more source

Molecular Mechanisms Used by Salmonella to Evade the Immune System [PDF]

, 2017
Human and animal pathogens are able to circumvent, at least temporarily, the sophisticated immune defenses of their hosts. Several serovars of the Gram-negative bacterium Salmonella enterica have been used as models for the study of pathogen-host ...
Bernal Bayard, Joaquín, Ramos Morales, Francisco   +1 more
core   +1 more source

Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell–cell junctions during neural tube formation

Developmental Dynamics, EarlyView.
Abstract Background Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout
Derrick Thomas, Brittany M. Hufft‐Martinez, Zarna Lalwani, Vi Pham, Mary Elmeniawi, An J. Tran, Jianming Xu, Irfan Saadi, Walid D. Fakhouri   +8 more
wiley   +1 more source

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance [PDF]

, 2017
Damaged mitochondria pose a lethal threat to cells that necessitates their prompt removal. The currently recognized mechanism for disposal of mitochondria is autophagy, where damaged organelles are marked for disposal via ubiquitylation by Parkin.
A Choudhury, A Hamacher-Brady, A Hoshino, A Kirchhofer, A Kuma, A Marchese, A Roczniak-Ferguson, A Zeigerer, AH Gaspar, C Campsteijn, C Raiborg, CH Davis, CS Zhang, D Narendra, DA Kubli, DA Kubli, DA Kubli, DC Rubinsztein, DJ Yamashiro, E Karwatowska-Prokopczuk, F Kanai, FR Maxfield, G Gong, G Twig, GL McLelland, GL McLelland, IH Lee, J Rink, JR Kremer, K Hayashida, K Hirosako, K Okatsu, KY Kim, M Komatsu, M Kundu, M Matsui, M Song, M Song, N Hariharan, NC McKnight, PA Ney, Q Sun, R Sahu, R Zoncu, RA Hanna, RN Day, S Geisler, S Hwang, S Jean, S Kaushik, S Phan, SG Roy, SJ Martin, SR Sriram, SR Yoshii, SS Lam, T Kitada, TD Cummins, TD Schmittgen, V Soubannier, WM Henne, WW Li, WX Ding, XM Liu, Y Chen, Y Nishida, Y Zhang, YR Chen   +67 more
core   +2 more sources

Interactions of rab5 with cytosolic proteins.

Journal of Biological Chemistry, 1992
Rab proteins, one of the subfamilies of ras-like small GTP-binding proteins, are attached to cellular compartments or transport vesicles and may determine the specificity of fusion between these compartments and vesicles. It has been proposed that they alternate between a membrane-bound and a cytosolic state during their functional cycle.
Kurzchalia, Teymuras V., Gorvel, Jean-Pierre, Dupree, Paul, Parton, Robert, Kellner, Roland, Houthaeve, Tony, Gruenberg, Jean, Simons, Kai   +7 more
openaire   +2 more sources