Results 1 to 10 of about 23,386 (141)

Targeting RAB7 in human B lymphoma by a small molecule inhibitor arrests tumor cell growth [PDF]

Frontiers in Oncology
RAB7, encoded by RAB7A in humans and Rab7 in mice, is a small GTPase that catalyzes endosome maturation. It mediates NF-κB activation through the assembly of intracellular membrane signalosomes in stimulated normal B cells and plays a B cell-intrinsic ...
Maria Fernandez, Rui Wang, Jingwei Wang, Shuai Wu, Kenneth Holder, Alia Nazarullah, Ricardo C. T. Aguiar, Ricardo C. T. Aguiar, Zijun Y. Xu-Monette, Zijun Y. Xu-Monette, Ken H. Young, Ken H. Young, Hui Yan, Zhenming Xu   +13 more
doaj   +2 more sources

AP2A1 activates Rab7 to promote axonal autophagosome transport and slow the progression of Alzheimer’s disease [PDF]

Alzheimer’s Research & Therapy
Background Dysregulation retrograde axonal transport in neurons results in autophagosome accumulation, enhancing amyloid β (Aβ) production and accelerating Alzheimer’s disease (AD) progression.
Yangyang Wang, Siyu Li, Xiao Liang, Jianing Fan, Shijie Li, Fanlin Zhou, Xiaoju Li, Mengmeng Lai, Dianmao Feng, Yu Li   +9 more
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Induced mitochondrial deficit by NDUFS3 transient silencing reduces RAB7 expression and causes lysosomal dysfunction in pancreatic cancer cells [PDF]

Cell Communication and Signaling
Background RAB7 is a small GTPase with multiple cellular roles, regulating late endocytic trafficking and lysosomal biogenesis, influencing mitochondria-lysosome crosstalk, and contributing to many mitochondrial processes.
Giulia Girolimetti, Sinforosa Gagliardi, Paola Cordella, Grazia Bramato, Riccardo Di Corato, Roberta Romano, Flora Guerra, Cecilia Bucci   +7 more
doaj   +2 more sources

Rab14 regulates the maturation of macrophage phagosomes containing the fungal pathogen Candida albicans and the outcome of the host-pathogen interaction [PDF]

, 2015
Date of Acceptance: 02/02/2015 Copyright © 2015, American Society for Microbiology.
Bain, Judith M, Erwig, Lars-Peter, Gow, Neil A R, Lyall, Natalie, Okai, Blessing   +4 more
core   +6 more sources

Expected and unexpected roles for dynein regulation of dendritic late endosomes

Autophagy Reports, 2022
Dendrites differ from axons in multiple ways, including the presence of minus-end out microtubules intermixed with the more conventional plus-end out microtubules.
Chan Choo Yap, Bettina Winckler
doaj   +1 more source

Rab7 is required for mesoderm patterning and gastrulation in Xenopus

Biology Open, 2021
Early embryogenesis requires tightly controlled temporal and spatial coordination of cellular behavior and signaling. Modulations are achieved at multiple levels, from cellular transcription to tissue-scale behavior.
Jennifer Kreis, Fee M. Wielath, Philipp Vick   +2 more
doaj   +1 more source

Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles

Journal of Extracellular Vesicles, 2021
Multivesicular bodies (MVBs) fuse with not only the plasma membranes to release extracellular vesicles (EVs) but also lysosomes for degradation. Rab7 participates in the lysosomal targeting of MVBs.
Xuefeng Fei, Zhijie Li, Diya Yang, Xianghui Kong, Xinliang Lu, Yingying Shen, Xu Li, Shaofang Xie, Jiaoli Wang, Yongchao Zhao, Yi Sun, Jing Zhang, Zhaoming Ye, Jianli Wang, Zhijian Cai   +14 more
doaj   +1 more source

Effects of Rab7 gene up-regulation on renal fibrosis induced by unilateral ureteral obstruction [PDF]

Brazilian Journal of Medical and Biological Research, 2020
Rab7, an important member of the Rab family, is closely related to autophagy, endocytosis, apoptosis, and tumor suppression but few studies have described its association with renal fibrosis.
Qing Xu, Lei Liu, Yiqiong Yang, Zhi Wang, Yingying Cai, Tingting Hong, Pingsheng Chen   +6 more
doaj   +2 more sources

Characterization of Zika virus endocytic pathways in human glioblastoma cells [PDF]

, 2020
Zika virus (ZIKV) infections can cause microcephaly and neurological disorders. However, the early infection events of ZIKV in neural cells remain to be characterized. Here, by using a combination of pharmacological and molecular approaches and the human
Du, T, Fu, M, Griffin, GE, Hu, Q, Li, C, Li, M, Liu, Y, Ni, F, Wang, H, Zhang, D, Zhang, M, Zheng, Z   +11 more
core   +1 more source

A conserved and regulated mechanism drives endosomal Rab transition

eLife, 2020
Endosomes and lysosomes harbor Rab5 and Rab7 on their surface as key proteins involved in their identity, biogenesis, and fusion. Rab activation requires a guanine nucleotide exchange factor (GEF), which is Mon1-Ccz1 for Rab7. During endosome maturation,
Lars Langemeyer, Ann-Christin Borchers, Eric Herrmann, Nadia Füllbrunn, Yaping Han, Angela Perz, Kathrin Auffarth, Daniel Kümmel, Christian Ungermann   +8 more
doaj   +1 more source