Results 11 to 20 of about 23,291 (205)
Revisiting Rab7 Functions in Mammalian Autophagy: Rab7 Knockout Studies [PDF]
Cells, 2018 Rab7 (or Ypt7 in yeast) is one of the well-characterized members of the Rab family small GTPases, which serve as master regulators of membrane trafficking in eukaryotes.
Yoshihiko Kuchitsu, Mitsunori Fukuda
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Multiple Roles of the Small GTPase Rab7 [PDF]
Cells, 2016 Rab7 is a small GTPase that belongs to the Rab family and controls transport to late endocytic compartments such as late endosomes and lysosomes. The mechanism of action of Rab7 in the late endocytic pathway has been extensively studied.
Flora Guerra, Cecilia Bucci
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RAB7 GTPases as coordinators of plant endomembrane traffic
Frontiers in Plant Science, 2023 The ras gene from rat brain (RAB) family of small GTPases is highly conserved among eukaryotes and regulates endomembrane trafficking pathways. RAB7, in particular, has been linked to various processes involved in regulating endocytic and autophagic ...
Cecilia Rodriguez-Furlan +2 more
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Phylogeny and evolution of Rab7 and Rab9 proteins [PDF]
BMC Evolutionary Biology, 2009 Background An important role in the evolution of intracellular trafficking machinery in eukaryotes played small GTPases belonging to the Rab family known as pivotal regulators of vesicle docking, fusion and transport.
Wyroba Elżbieta, Mackiewicz Paweł
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Inactivation of Macrophage Rab7 by Burkholderia cenocepacia [PDF]
Journal of Innate Immunity, 2010 Strains of the <i>Burkholderia cepacia </i>complex can survive within macrophages by arresting the maturation of phagocytic vacuoles. The bacteria preclude fusion of the phagosome with lysosomes by a process that is poorly understood. Using murine macrophages, we investigated the stage at which maturation is arrested and analyzed the ...
Huynh, Kassidy K +4 more
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A conserved and regulated mechanism drives endosomal Rab transition
eLife, 2020 Endosomes and lysosomes harbor Rab5 and Rab7 on their surface as key proteins involved in their identity, biogenesis, and fusion. Rab activation requires a guanine nucleotide exchange factor (GEF), which is Mon1-Ccz1 for Rab7. During endosome maturation,
Lars Langemeyer +8 more
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This Is the End: Regulation of Rab7 Nucleotide Binding in Endolysosomal Trafficking and Autophagy
Frontiers in Cell and Developmental Biology, 2018 Rab7 – or in yeast, Ypt7p – governs membrane trafficking in the late endocytic and autophagic pathways. Rab7 also regulates mitochondrion-lysosome contacts, the sites of mitochondrial fission.
Christopher Stroupe
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Structural basis of human PDZD8–Rab7 interaction for the ER-late endosome tethering
Scientific Reports, 2021 The membrane contact sites (MCSs) between the ER and late endosomes (LEs) are essential for the regulation of endosomal protein sorting, dynamics, and motility.
Haider Khan +3 more
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The activation of KSHV lytic cycle blocks autophagy in PEL cells [PDF]
, 2015 This study confirms that autophagy is activated concomitantly with KSHV lytic cycle induction, and that autophagy inhibition by BECN1 knockdown reduces viral lytic gene expression.
CIRONE, Mara +7 more
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Biology Open, 2020 Vps54 is a subunit of the Golgi-associated retrograde protein (GARP) complex, which is involved in tethering endosome-derived vesicles to the trans-Golgi network (TGN).
Prajal H. Patel +5 more
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