Results 21 to 30 of about 23,457 (205)
Scientific Reports, 2023 Rab7 is known to function in the autophagy and endocytosis pathways in eukaryocytes and is related to various diseases. We recently reported that Rab7 plays a protective role against acute pancreatitis.
Kenichi Takahashi +7 more
doaj +1 more source
Post-translational modifications: How to modulate Rab7 functions [PDF]
Small GTPases, 2017 The small GTPase Rab7 is the main regulator of membrane trafficking at late endosomes. This small GTPase regulates endosome-to-trans Golgi Network trafficking of sorting receptors, membrane fusion of late endosomes to lysosomes, and autophagosomes to lysosomes during autophagy. Rab7, like all Rab GTPases, binds downstream effectors coordinating several
Graziana Modica, Stephane Lefrancois
openaire +3 more sources
Rubicon controls endosome maturation as a Rab7 effector [PDF]
Proceedings of the National Academy of Sciences, 2010 The activation and recruitment of the small GTPase Rab7 to early endosome is a critical step for early to late endosome maturation, a process that requires the class III phosphatidylinositol 3-kinase (PI3KC3) and GTPase regulators. However, the molecular mechanism underlying Rab7 activation and endosome maturation is still poorly defined.
Qiming, Sun +4 more
openaire +2 more sources
Scientific Reports, 2022 We have shown previously that the lysosomal a3 isoform of the a subunit of vacuolar-type ATPase (V-ATPase) interacts with inactive (GDP-bound form) Rab7, a small GTPase that regulates late endosome/lysosome trafficking, and that a3 recruits Rab7 to ...
Naomi Matsumoto +4 more
doaj +1 more source
The activation of KSHV lytic cycle blocks autophagy in PEL cells [PDF]
, 2015 This study confirms that autophagy is activated concomitantly with KSHV lytic cycle induction, and that autophagy inhibition by BECN1 knockdown reduces viral lytic gene expression.
CIRONE, Mara +7 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2022 Gastrulation denotes a very important developmental process, which includes significant structural tissue rearrangements and patterning events that shape the emerging vertebrate organism.
Jennifer Kreis +4 more
doaj +1 more source
Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA as Rab-effector kinases in malaria parasites [PDF]
, 2011 Background information The pathology causing stages of the human malaria parasite Plasmodium falciparum reside within red blood cells that are devoid of any regulated transport system.
Bourdoncle, P. +9 more
core +1 more source
Structural basis of human ORP1-Rab7 interaction for the late-endosome and lysosome targeting.
PLoS ONE, 2019 Oxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) constitute a family of lipid transfer proteins conserved in eukaryotes. ORP1 transports cholesterol at the interface between the late endosomes/lysosomes (LELs) and the endoplasmic ...
Junsen Tong +3 more
doaj +1 more source
Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy
eLife, 2014 Damaged mitochondria can be selectively eliminated by mitophagy. Although two gene products mutated in Parkinson’s disease, PINK1, and Parkin have been found to play a central role in triggering mitophagy in mammals, how the pre-autophagosomal isolation ...
Koji Yamano +4 more
doaj +1 more source
HUNK Phosphorylates Rubicon to Support Autophagy [PDF]
, 2019 Background: Autophagy is a catabolic cellular recycling pathway that is essential for maintaining intracellular homeostasis. Autophagosome formation is achieved via the coordination of the Beclin-1 protein complex.
Abt, Melissa +5 more
core +1 more source