Results 1 to 10 of about 2,150 (202)
SARS-CoV-2 RdRp Inhibitors Selected from a Cell-Based SARS-CoV-2 RdRp Activity Assay System
Biomedicines, 2021 The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), urgently needs effective prophylactic and therapeutic drugs. RNA-dependent RNA polymerase (RdRp), essential for replicating and transcribing a viral RNA genome,
Jung Sun Min, Sunoh Kwon, Young-Hee Jin
doaj +3 more sources
Experimental Gerontology, 2021 RT-qPCR is the most reliable molecular method for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we analyzed results of RT-qPCR obtained for 3044 patients diagnosed as SARS-CoV-2-positive using four different molecular tests utilizing five RNA sequences.
Justyna Mikuła‐Pietrasik +1 more
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RdRp mutations are associated with SARS-CoV-2 genome evolution
PeerJ, 2020 AbstractCOVID-19, caused by the novel SARS-CoV-2 virus, started in China in late 2019, and soon became a global pandemic. With the help of thousands of viral genome sequences that have been accumulating, it has become possible to track the evolution of viral genome over time as it spread across the world.
Doğa Eskier +3 more
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RNA-dependent RNA polymerase (RdRp) natural antiviral inhibitors: a review [PDF]
Medicinal Chemistry Research, 2022 Viral diseases are the cause of many global epidemics, leading to deaths, affecting the quality of life of populations, and impairing public health. The limitations in the treatment of viral diseases and the constant resistance to conventional antiviral treatments encourage researchers to discover new compounds.
Daniela Regina Buch Leite +9 more
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Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity. [PDF]
PLoS Pathogens, 2015 For many emerging and re-emerging infectious diseases, definitive solutions via sterilizing adaptive immunity may require years or decades to develop, if they are even possible.
Meghan M Painter +11 more
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An OTU deubiquitinating enzyme in Eimeria tenella interacts with Eimeria tenella virus RDRP [PDF]
Parasites & Vectors, 2018 Background Chicken coccidiosis, a disease caused by seven species of Eimeria (Apicomplexa: Coccidia), inflicts severe economic losses on the poultry industry. Eimeria tenella is the one of the most virulent species pathogenic to chickens.
Pu Wang +5 more
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RdRp or RT, That is the Question [PDF]
Molecular Biology and Evolution, 2021 Abstract The RNA-dependent RNA polymerase (RdRp) of all known double-stranded RNA viruses is located within the viral particle and is responsible for the transcription and replication of the viral genome. Through an RT-PCR assay, we determined that purified virions, in vitro translated RdRp proteins, and purified recombinant RdRp ...
Mahtab Peyambari +2 more
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Snapshots of a Non-Canonical RdRP in Action [PDF]
Viruses, 2021 RNA viruses typically encode their own RNA-dependent RNA polymerase (RdRP) to ensure genome replication and transcription. The closed “right hand” architecture of RdRPs encircles seven conserved structural motifs (A to G) that regulate the polymerization activity.
Diego S. Ferrero +2 more
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Exploring RdRp–remdesivir interactions to screen RdRp inhibitors for the management of novel coronavirus 2019-nCoV [PDF]
SAR and QSAR in Environmental Research, 2020 A novel coronavirus recently identified in Wuhan, China (2019-nCoV) has resulted in an increasing number of patients globally, and has become a highly lethal pathogenic member of the coronavirus family affecting humans. 2019-nCoV has established itself as one of the most threatening pandemics that human beings have faced, and therefore analysis and ...
Singh, P.K., Pathania, S., Rawal, R.K.
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The worldwide search for the new mutations in the RNA-directed RNA Polymerase domain of SARS-CoV-2
Macedonian Veterinary Review, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is an RNA virus, responsible for the current pandemic outbreak. In total, 200 genomes of the SARS‐CoV‐2 strains from four host organisms have been analyzed.
Siarhei A. Dabravolski +1 more
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