Results 1 to 10 of about 45,973 (207)
SARS-CoV-2 RdRp Inhibitors Selected from a Cell-Based SARS-CoV-2 RdRp Activity Assay System
Biomedicines, 2021 The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), urgently needs effective prophylactic and therapeutic drugs. RNA-dependent RNA polymerase (RdRp), essential for replicating and transcribing a viral RNA genome,
Jung Sun Min, Sunoh Kwon, Young-Hee Jin
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The worldwide search for the new mutations in the RNA-directed RNA Polymerase domain of SARS-CoV-2
Macedonian Veterinary Review, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is an RNA virus, responsible for the current pandemic outbreak. In total, 200 genomes of the SARS‐CoV‐2 strains from four host organisms have been analyzed.
Siarhei A. Dabravolski +1 more
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Медицинская иммунология, 2022 Rapid emergence and evolution of novel SARS-CoV-2 variants has raised concerns about their potential impact on efficiency of currently available vaccines.
Ali A. Dawood
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Analysis the Effectiveness of Remdesivir, Galidesivir, Sofosbuvir, Tenofovir and Ribavirin as Potential Therapeutic Drug target against SARS-Cov-2 RNA-Dependent RNA Polymerase (RdRp): An in Silico Docking Study [PDF]
Journal of Research in Applied and Basic Medical Sciences, 2023 Background & Aims: The active site of RdRp-CoV is highly conserved, with two successive and surface-accessible aspartates in a beta-turn structure. Antiviral drugs Remdesivir, Galidesivir, Tenofovir, Sofosbuvir, and Ribavirin are known as inhibitors of ...
Rajneesh Prajapat, Suman Jain
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RNA-Dependent RNA Polymerase of the Second Human Pegivirus Exhibits a High-Fidelity Feature
Microbiology Spectrum, 2022 The virus-encoded RNA-dependent RNA polymerase (RdRp) is responsible for viral replication, and its fidelity is closely related to viral diversity, pathogenesis, virulence, and fitness.
Shuyi Chen +10 more
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The EuroBiotech Journal, 2021 A reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) is regarded as the most sensitive method available and is being used for screening procedure for all incoming passengers to Northern Cyprus for SARS-CoV-2.
Tuncel Gulten +10 more
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Biomolecules, 2021 SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) protein is the target for the antiviral drug Remdesivir (RDV). With RDV clinical trials on COVID-19 patients showing a reduced hospitalisation time.
Anwar Mohammad +3 more
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Orphanet Journal of Rare Diseases, 2022 Metachromatic Leukodystrophy (MLD) is a rare, autosomal recessive lysosomal storage disorder caused by a deficiency of the enzyme arylsulfatase A (ARSA).
Georgina Morton +5 more
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Molecular Evolution of RNA-Dependent RNA Polymerase Region in Norovirus Genogroup I
Viruses, 2023 Norovirus is the leading viral agent of gastroenteritis in humans. RNA-dependent RNA polymerase (RdRp) is essential in the replication of norovirus RNA. Here, we present a comprehensive evolutionary analysis of the norovirus GI RdRp gene.
Nan Zhou +4 more
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PLoS ONE, 2021 A newly identified coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), has spread rapidly from its epicenter in China to more than 150 countries across six continents.
Woong Sik Jang +10 more
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