Results 61 to 70 of about 2,150 (202)
Identification of novel mutations in RNA-dependent RNA polymerases of SARS-CoV-2 and their implications on its protein structure [PDF]
PeerJ, 2020 The rapid development of the SARS-CoV-2 mediated COVID-19 pandemic has been the cause of significant health concern, highlighting the immediate need for effective antivirals. SARS-CoV-2 is an RNA virus that has an inherently high mutation rate.
Gyanendra Bahadur Chand +2 more
doaj +2 more sources
Molecular Plant Pathology, Volume 24, Issue 2, Page 179-187, February 2023., 2023 Interaction between binding immunoglobulin protein 2 (BiP2) and NIb of potyvirus promotes virus infections, making BiP2 a good candidate for gene modification to generate a resistant cultivar against potyviruses. Abstract Infection of viruses from the genera Bromovirus, Potyvirus, and Potexvirus in Nicotiana benthamiana induces significant up ...
Kristin Widyasari +2 more
wiley +1 more source
Advanced Science, 2023 Photoinduced reversible deactivation radical polymerization (photo‐RDRP) or photoinduced controlled/living radical polymerization has emerged as a versatile and powerful technique for preparing functional and advanced polymer materials under mild ...
Zilong Wu, Cyrille Boyer
doaj +1 more source
Targeting RdRp of SARS-CoV-2 with De Novo Molecule Generation
ACS Applied Bio Materials, 2023 Viruses are known for their extremely high mutation rates, allowing them to evade both the human immune system and many forms of standard medicine. Despite this, the RNA Dependent RNA Polymerase (RdRp) of the RNA viruses has been largely conserved, and any significant mutation to this protein is unlikely.
Amal Vijay +2 more
openaire +2 more sources
Virology Journal, 2021 Background The development of an influenza RNA-dependent RNA polymerase (RdRp) inhibitor is required; therefore, a method for evaluating the activity of influenza RdRp needs to be developed.
Yuka Horio +2 more
doaj +1 more source
Predicting inhibitors for SARS-CoV-2 RNA-dependent RNA polymerase using machine learning and virtual screening [PDF]
arXiv, 2020 Global coronavirus disease pandemic (COVID-19) caused by newly identified SARS- CoV-2 coronavirus continues to claim the lives of thousands of people worldwide. The unavailability of specific medications to treat COVID-19 has led to drug repositioning efforts using various approaches, including computational analyses.
arxiv
Cu(0)-RDRP of acrylates using an alkyl iodide initiator
Polymer Chemistry, 2023 In the vast majority of atom transfer radical polymerizations, alkyl bromides or alkyl chlorides are commonly employed as initiators. Herein, alkyl iodides are demonstrated as ATRP initiators.
Kostas Parkatzidis +3 more
openaire +2 more sources
Antiviral effects and mechanism of Qi pi pill against influenza viruses
Animal Models and Experimental Medicine, EarlyView.Qi pi pill presents anti‐influenza effect and inhibits viral replication in vitro by targeting both the viral RNA replication and the release of new viral particles. Furthermore, QPP modulates the production of proinflammatory cytokines induced by influenza infection in host cells.
Chengcheng Zhang +10 more
wiley +1 more source
International Journal of TechnologyThe previous outbreaks of syndrome coronavirus 2 (SARS-CoV-2) are indications of the need for effective antiviral agents to mitigate disease severity and future outbreaks. In this context, natural products such as propolis have gained attention for their
Safira Candra Asih +8 more
doaj +1 more source
Frontiers in Microbiology, 2019 The RNA-dependent RNA polymerases (RdRPs) encoded by the RNA viruses are a unique class of nucleic acid polymerases. Each viral RdRP contains a 500–600 residue catalytic module with palm, fingers, and thumb domains forming an encircled human right hand ...
Hengxia Jia, Hengxia Jia, Peng Gong
doaj +1 more source