Results 91 to 100 of about 6,562 (195)

Abstract Supplement

Pulmonary Medicine, Volume 2026, Issue 1, 2026.
 
Marzia Folegani, Semonti Nandi
wiley   +1 more source

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source

Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice [PDF]

, 2014
Sepsis and septic shock, caused by an excessive systemic host-inflammatory response, are associated with high morbidity and mortality. The complement system and TLRs provide important pattern recognition receptors initiating the cytokine storm by ...
Barratt-Due, Andreas, Denk, Stephanie, Espevik, Terje, Gaus, Wilhelm, Huber-Lang, Markus, Mollnes, Tom E., Nilsson, Per H., Nunn, Miles A., Pischke, Søren E., Sandanger, Øystein   +9 more
core   +1 more source

Complement‐mediated vascular inflammation contributes to anti‐amyloid mAb‐induced ARIA in mice

Alzheimer's &Dementia, Volume 21, Issue S7, December 2025.
Abstract Background Anti‐amyloid antibody immunotherapy in Alzheimer’s disease (AD) has been associated with amyloid‐related imaging abnormalities (ARIA) with vasogenic edema and microhemorrhages in the brain, especially in ApoE4 carriers.
Praveen Bathini, Ilina Navani, Cynthia A Lemere   +2 more
wiley   +1 more source

The Complement Anaphylatoxin C5a Receptor Contributes to Obese Adipose Tissue Inflammation and Insulin Resistance [PDF]

The Journal of Immunology, 2013
Abstract Obese adipose tissue (AT) inflammation contributes critically to development of insulin resistance. The complement anaphylatoxin C5a receptor (C5aR) has been implicated in inflammatory processes and as regulator of macrophage activation and polarization.
Phieler, Julia, Chung, Kyoung-Jin, Chatzigeorgiou, Antonios, Klotzsche-von Ameln, Anne, García-Martín, Rubén, Sprott, David, Moisidou, Maria, Tzanavari, Theodora, Ludwig, Barbara, Baraban, Elena, Ehrhart-Bornstein, Monika, Bornstein, Stefan R., Mziaut, Hassan, Solimena, Michele, Karalis, Katia P., Economopoulou, Matina, Lambris, John D., Chavakis, Triantafyllos   +17 more
openaire   +3 more sources

Pulmonary intravascular macrophages: Prime suspects as cellular mediators of porcine CARPA [PDF]

, 2015
Pigs provide a highly sensitive and quantitative in vivo model for complement (C) activation-related pseudoallergy (CARPA), a hypersensitivity reaction caused by some state-of-art nanomedicines.
Aharonson, Aharonson, Atwal, Atwal, Atwal, Atwal, Basu, Basu, Bertram TA, Bertram TA, Bertram TA, Bertram TA, Bhatia, Bhatia, Cantu, Cantu, Carrasco, Carrasco, Carrasco, Carrasco, Castells, Castells, Castells, Castells, Chang, Chang, Chitko, Chitko, DeCamp, DeCamp, Domokos Csukás, Duke, Duke, Dzsi, Dzsi, Ezquerra, Ezquerra, Fine, Fine, Gabizon, Gabizon, Gaca, Gaca, György Wéber, Henson, Henson, Holt, Holt, Humphries, Humphries, Jacobson, Jacobson, János Szebeni, Klingensmith, Klingensmith, Larsen, Larsen, Leifsson, Leifsson, Lohmann, Lohmann, Longworth, Longworth, Longworth, Longworth, László Rosivall, MA, MA, McCarthy, McCarthy, Miot, Miot, Miyamoto, Miyamoto, Mizgerd, Mizgerd, Molina, Molina, Parbhakar, Parbhakar, Parbhakar, Parbhakar, Puchner, Puchner, Rudolf Urbanics, Sakai, Sakai, Schneberger, Schneberger, Singh, Singh, Singh, Singh, Singh, Singh, Singh, Singh, Singh, Singh, Singh, Singh, Siore, Siore, Sone, Sone, Staub, Staub, Staub, Staub, Staub, Staub, Szebeni, Szebeni, Szebeni, Szebeni, Szebeni, Szebeni, Szebeni, Szebeni, Szebeni, Szebeni, Szebeni, Szebeni, Thenappan, Thenappan, Warner, Warner, Warner, Warner, Warner, Warner, Warner, Warner, Winkler, Winkler, Winkler, Winkler   +136 more
core   +1 more source

Inflammation and genetics in myo‐pericardial diseases: Insights from the Italian Study Group on Cardiomyopathies and Pericardial Diseases

ESC Heart Failure, Volume 12, Issue 6, Page 3987-3999, December 2025.
Proposed management of myo‐pericardial diseases. A systematic interdisciplinary approach to myo‐pericardial disease is essential to reach a correct diagnosis, starting from multiparametric characterization including EKG, echocardiography with GLS, laboratory exams and CMR or, in case of electric or haemodynamic instability, EMB.
Marco Merlo, Giulia Bassetto, Antonio Cannatà, Alberto Aimo, Camillo Autore, Barbara Bauce, Elena Biagini, Francesco Cappelli, Silvia Castelletti, Flavio D'Ascenzi, Cesare de Gregorio, Giuseppe Limongelli, Francesca Marzo, Beatrice Musumeci, Giacomo Tini, Roberto Pedrinelli, Pasquale Perrone Filardi, Gianfranco Sinagra, Massimo Imazio   +18 more
wiley   +1 more source

The complement receptor C5aR controls acute inflammation and astrogliosis following spinal cord injury [PDF]

, 2015
This study investigated the role of the complement activation fragment C5a in secondary pathology following contusive spinal cord injury (SCI). C5ar(-/-) mice, which lack the signaling receptor for C5a, displayed signs of improved locomotor recovery and ...
Biggins, Patrick J., Brennan, Faith H., Franklin, Robin J. M., Gordon, Richard, Lao, Hong W., Ruitenberg, Marc J., Taylor, Stephen M., Woodruff, Trent M.   +7 more
core   +1 more source

Phosphatidylinositol‐4,5‐bisphosphate 3‐kinase (PI3K) inhibitors reduce vascular inflammation in vitro and in vivo

British Journal of Pharmacology, Volume 182, Issue 24, Page 6028-6042, December 2025.
Background and Purpose Endothelial cells play central roles in increasing vascular permeability and leukocyte recruitment. Therapeutic approaches for treating endothelial cell barrier dysfunction to reduce unwanted fluid accumulation in tissues are limited.
Hiba Chaudhry, Ali A. Zarban, Silvia Cellone Trevelin, Xenia Kodji, Camilla Cerutti, Xiaoqing Xiong, Fulye Argunhan, Ajay M. Shah, Anne J. Ridley, Susan D. Brain   +9 more
wiley   +1 more source

Labile Heme Aggravates Renal Inflammation and Complement Activation After Ischemia Reperfusion Injury

Frontiers in Immunology, 2019
Background: Ischemia reperfusion injury (IRI) plays a major role in solid organ transplantation. The length of warm ischemia time is critical for the extent of tissue damage in renal IRI.
Li Wang, Vijith Vijayan, Mi-Sun Jang, Anja Thorenz, Robert Greite, Song Rong, Rongjun Chen, Nelli Shushakova, Igor Tudorache, Katja Derlin, Pooja Pradhan, Kukuh Madyaningrana, Nodir Madrahimov, Jan Hinrich Bräsen, Ralf Lichtinghagen, Cees van Kooten, Markus Huber-Lang, Hermann Haller, Stephan Immenschuh, Faikah Gueler   +19 more
doaj   +1 more source