Results 31 to 40 of about 6,562 (195)

Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis

Acta Neuropathologica Communications, 2018
The complement system is a key driver of neuroinflammation. Activation of complement by all pathways, results in the formation of the anaphylatoxin C5a and the membrane attack complex (MAC).
Iliana Michailidou, Aldo Jongejan, Jeroen P. Vreijling, Theodosia Georgakopoulou, Marit B. de Wissel, Ruud A. Wolterman, Patrick Ruizendaal, Ngaisah Klar-Mohamad, Anita E. Grootemaat, Daisy I. Picavet, Vinod Kumar, Cees van Kooten, Trent M. Woodruff, B. Paul Morgan, Nicole N. van der Wel, Valeria Ramaglia, Kees Fluiter, Frank Baas   +17 more
doaj   +1 more source

Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling. [PDF]

, 2016
The complement cascade is comprised of a highly sophisticated network of innate immune proteins that are activated in response to invading pathogens or tissue injury. The complement activation peptide, C5a, binds two seven transmembrane receptors, namely
Blaskovich, M.A., Clark, R.J., Cooper, M.A., Croker, D.E., Floudas, C.A., Halai, R., Kaeslin, G., Monk, P.N., Morikis, D., Schofield, Z., Woodruff, T.M., Wu, M.C.   +11 more
core   +1 more source

Anaphylatoxin C5a-induced toll-like receptor 4 signaling in bovine neutrophils [PDF]

Journal of Dairy Science, 2011
It is well known that signaling in neutrophils through both the complement component 5a (C5a) and C5a receptor (C5aR) and the toll-like receptor 4 (TLR4) pathways plays an essential role in innate defense. Neutrophil dysfunction, as seen during sepsis in severe mastitis during the periparturient period, is correlated with elevated concentrations of ...
Stevens, M.G.H., van Poucke, M., Peelman, L.J., Rainard, Pascal, de Spiegeleer, B., Rogiers, C., van de Walle, G.R., Duchateau, Laure, Burvenich, Christian   +8 more
openaire   +3 more sources

Deletion of the Complement C5a Receptor Alleviates the Severity of Acute Pneumococcal Otitis Media following Influenza A Virus Infection in Mice [PDF]

, 2014
There is considerable evidence that influenza A virus (IAV) promotes adherence, colonization, and superinfection by S. pneumoniae (Spn) and contributes to the pathogenesis of otitis media (OM).
Bowman, Andrew S., Clancy, Caitlin, Douthitt, Kelsey, He, Yujuan, Lambert, Garrett, Li, Yong Xing, Stahl, Gregory L., Thurman, Joshua M., Tong, Hua Hua   +8 more
core   +6 more sources

Treatment of Rare Inflammatory Kidney Diseases: Drugs Targeting the Terminal Complement Pathway

Frontiers in Immunology, 2020
The complement system comprises the frontline of the innate immune system. Triggered by pathogenic surface patterns in different pathways, the cascade concludes with the formation of a membrane attack complex (MAC; complement components C5b to C9) and ...
Marion Anliker-Ort, Marion Anliker-Ort, Jasper Dingemanse, John van den Anker, John van den Anker, Priska Kaufmann   +5 more
doaj   +1 more source

Bacterial polyphosphates induce CXCL4 and synergize with complement anaphylatoxin C5a in lung injury

Frontiers in Immunology, 2022
Polyphosphates are linear polymers of inorganic phosphates that exist in all living cells and serve pleiotropic functions. Bacteria produce long-chain polyphosphates, which can interfere with host defense to infection.
Julian Roewe, Sarah Walachowski, Arjun Sharma, Arjun Sharma, Kayleigh A. Berthiaume, Christoph Reinhardt, Markus Bosmann, Markus Bosmann   +7 more
doaj   +1 more source

The interaction between C 5a and both C 5a R and C 5 L 2 receptors is required for production of G ‐ CSF during acute inflammation [PDF]

, 2013
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99020/1/eji2635 ...
Bamberg, Bosmann, Bosmann, Bosmann, Bosmann, Bosmann, Bosmann, Cain, Chen, Gerard, Gerard, Gerard, Hawlisch, Hopken, Huber-Lang, Jalili, Kourtzelis, Lajoie, Lalli, Laudes, Lee, Okinaga, Ricklin, Riedemann, Riedemann, Rittirsch, Strainic, Wetsel, Wittmann, Zhang, Zhang, Zheng   +31 more
core   +1 more source

TPST2-mediated receptor tyrosine sulfation enhances leukocidin cytotoxicity and S. aureus infection

Frontiers in Immunology, 2023
BackgroundAn essential fact underlying the severity of Staphylococcus aureus (S. aureus) infection is the bicomponent leukocidins released by the pathogen to target and lyse host phagocytes through specific binding cell membrane receptors.
Jie He, Xianggui Yang, Kai Yang, Honglin Xu, Cheng Chen, Junxiong Wang, Jun Zeng   +6 more
doaj   +1 more source

Cardiopulmonary and hemodynamic changes in complement activation-related pseudoallergy [PDF]

, 2013
Complement activation-related pseudoallergy (CARPA) is a frequent side effect of intravenous therapies with nanoparticle-containing drugs and biologicals that are recognized by the immune system as foreign.
Dézsi, László, Rosivall, László, Szebeni, János, Szénási, Gábor, Urbanics R   +4 more
core   +1 more source

Characterization of a Receptor for C5a Anaphylatoxin on Human Eosinophils

Journal of Biological Chemistry, 1989
The complement anaphylatoxin peptide C5a is well known to activate human polymorphonuclear leukocytes through receptor-mediated processes. C5a has also been reported to activate eosinophils for both chemotaxis and hexose uptake. We characterized the receptor molecule for human C5a on human eosinophils and compared it with the receptor on human ...
N P, Gerard, M K, Hodges, J M, Drazen, P F, Weller, C, Gerard   +4 more
openaire   +2 more sources