The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]
, 2018 The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J +4 more
core +1 more source
Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing. [PDF]
PLoS ONE, 2017 The anaphylatoxin receptor C5aR1 plays an important role not only in innate immune responses, but also in bone metabolism and fracture healing, being highly expressed on immune and bone cells, including osteoblasts and osteoclasts.
Stephanie Bergdolt +7 more
doaj +1 more source
Complement in the homeostatic and ischemic brain [PDF]
, 2015 The complement system is a component of the immune system involved in both recognition and response to pathogens, and it is implicated in an increasing number of homeostatic and disease processes. It is well documented that reperfusion of ischemic tissue
Aivazian +129 more
core +3 more sources
Frontiers in Immunology, 2023 IntroductionDNA methylation was one of the most important modification in epigenetics and played an important role in immune response. Since the introduction of Scophthalmus maximus, the scale of breeding has continued to expand, during which diseases ...
Yingrui Li +5 more
doaj +1 more source
Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]
, 2015 Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Hristova, M, Rocha-Ferreira, E
core +1 more source
Complement is activated in progressive multiple sclerosis cortical grey matter lesions [PDF]
, 2016 The symptoms of multiple sclerosis (MS) are caused by damage to myelin and nerve cells in the brain and spinal cord. Inflammation is tightly linked with neurodegeneration, and it is the accumulation of neurodegeneration that underlies increasing ...
A Bose +51 more
core +2 more sources
C5L2, the Second C5a Anaphylatoxin Receptor, Suppresses LPS-Induced Acute Lung Injury [PDF]
American Journal of Respiratory Cell and Molecular Biology, 2016 LPS-induced lung injury in the mouse is one of the most robust experimental models used for studies of acute lung injury (ALI) and acute respiratory distress syndrome in humans. Prior clinical and experimental studies support an important role for complement activation, particularly production of C5a, in the pathophysiology of human ALI/acute ...
Ruobing, Wang +3 more
openaire +2 more sources
Mesenchymal stromal cells engage complement and complement receptor bearing innate effector cells to modulate immune responses. [PDF]
PLoS ONE, 2011 Infusion of human third-party mesenchymal stromal cells (MSCs) appears to be a promising therapy for acute graft-versus-host disease (aGvHD). To date, little is known about how MSCs interact with the body's innate immune system after clinical infusion ...
Guido Moll +12 more
doaj +1 more source
Enhancement of Human Cancer Cell Motility and Invasiveness by Anaphylatoxin C5a via Aberrantly Expressed C5a Receptor (CD88) [PDF]
Clinical Cancer Research, 2013 Abstract Purpose: The anaphylatoxin C5a is a chemoattractant that induces leukocyte migration via C5a receptor (C5aR). There is emerging evidence that C5a is generated in the cancer microenvironment. We therefore sought C5aR expression and a direct influence of the C5a–C5aR axis on cancer cells.
Hidetoshi, Nitta +14 more
openaire +2 more sources
An Inflammation-Centric View of Neurological Disease: Beyond the Neuron [PDF]
, 2018 Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair.
Facci, Laura +3 more
core +2 more sources