Results 51 to 60 of about 6,562 (195)

The N-formyl peptide receptors and the anaphylatoxin C5a receptors: An overview

Biochimie, 2007
Leukocyte recruitment to sites of inflammation and infection is dependent on the presence of a gradient of locally produced chemotactic factors. This review is focused on current knowledge about the activation and regulation of chemoattractant receptors.
Rabiet, Marie-Josèphe, Huet, Emilie, Boulay, François   +2 more
openaire   +4 more sources

Sulfated Tyrosines Contribute to the Formation of the C5a Docking Site of the Human C5a Anaphylatoxin Receptor [PDF]

The Journal of Experimental Medicine, 2001
The complement anaphylatoxin C5a and its seven-transmembrane segment (7TMS) receptor play an important role in host defense and in a number of inflammation-associated pathologies. The NH2-terminal domain of the C5a receptor (C5aR/CD88) contributes substantially to its ability to bind C5a.
M, Farzan, C E, Schnitzler, N, Vasilieva, D, Leung, J, Kuhn, C, Gerard, N P, Gerard, H, Choe   +7 more
openaire   +2 more sources

The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres

Journal of Neuroinflammation, 2009
Background In the periphery, C5a acts through the G-protein coupled receptor CD88 to enhance/maintain inflammatory responses. In the brain, CD88 can be expressed on astrocytes, microglia and neurons.
Taylor Stephen M, Sah Pankaj, Lee John D, Sullivan Robert KP, Baiquni Gilang P, Crane James W, Noakes Peter G, Woodruff Trent M   +7 more
doaj   +1 more source

Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds. [PDF]

PLoS ONE, 2017
Diabetic non-healing wounds are a major clinical problem. The mechanisms leading to poor wound healing in diabetes are multifactorial but unresolved inflammation may be a major contributing factor.
Kenji M Cunnion, Neel K Krishna, Haree K Pallera, Angela Pineros-Fernandez, Magdielis Gregory Rivera, Pamela S Hair, Brittany P Lassiter, Ryan Huyck, Mary A Clements, Antoinette F Hood, George T Rodeheaver, Patrick S Cottler, Jerry L Nadler, Anca D Dobrian   +13 more
doaj   +1 more source

Toxoplasma Infection Induces Sustained Up-Regulation of Complement Factor B and C5a Receptor in the Mouse Brain via Microglial Activation: Implication for the Alternative Complement Pathway Activation and Anaphylatoxin Signaling in Cerebral Toxoplasmosis

Frontiers in Immunology, 2021
Toxoplasma gondii is a neurotropic protozoan parasite, which is linked to neurological manifestations in immunocompromised individuals as well as severe neurodevelopmental sequelae in congenital toxoplasmosis.
Noriko Shinjyo, Noriko Shinjyo, Noriko Shinjyo, Kenji Hikosaka, Yasutoshi Kido, Hiroki Yoshida, Kazumi Norose   +6 more
doaj   +1 more source

Rescue with an anti-inflammatory peptide of chickens infected H5N1 avian flu [PDF]

, 2009
Chickens suffering from avian flu caused by H5N1 influenza virus are destined to die within 2 days due to a systemic inflammatory response. Since HVJ infection (1,2) and influenza virus infection (3,4) cause infected cells to activate homologous serum ...
Alan A. Okada, Ekowati E. Handharyani, Hidechika H. Okada, Kazuhide K. Adachi, Masaki M. Imai, Noriko N. Okada, Retno Damajanti R. D. Soejoedono, Yasuhiro Tsukamoto   +7 more
core   +1 more source

The role of the complement system in traumatic brain injury: a review [PDF]

, 2018
Traumatic brain injury (TBI) is an important cause of disability and mortality in the western world. While the initial injury sustained results in damage, it is the subsequent secondary cascade that is thought to be the significant determinant of ...
A Alawieh, A Jauneau, A Kumar, Adnan Hammad, AG Therien, AH Stephan, AI Faden, AL Vescovi, B Oderfeld-Nowak, B Stevens, B-M Bellander, B-M Bellander, B-M Bellander, BJ Gabbe, BP Morgan, BP Morgan, C Cudrici, C Wang, CA Colton, CG Cochrane, D Cederberg, D Dupret, D Ricklin, D Shlosberg, DG Nicholls, DL Sewell, DN Abrous, DP Ankeny, DP Schafer, DT Fearon, E Makou, ED Ponomarev, EO Samstad, F Orsini, F Qiao, FH Brennan, G Arbore, G Winocur, GM Pasinetti, GT Manley, H Osaka, HD Manthey, HG Rus, HG Rus, HX Nguyen, I Leinhase, I Leinhase, I Leinhase, IP Karve, J Rogers, J van Beek, J van Beek, J Wetherington, JJ Ramirez, JL Cole, JR Dunkelberger, K Fluiter, K Färber, K Heese, K Järlestedt, K Pisalyaput, KA Kigerl, L Berliocchi, L Boos, L Longhi, L Longhi, L Soane, Laura Westacott, LG Coulthard, M Bénard, M Bénard, M Fosbrink, M Lévi-Strauss, M Moriyama, M Rancan, M-C Mathieu, Malik Zaben, MC Carroll, MC Carroll, MC Garrett, MD Saxe, ME Benoit, ME Medof, MJ Rutkowski, MK Liszewski, ML Pearn, MM Ruseva, N Sanai, N Shinjyo, NA Martin, O Butovsky, P Gasque, PF Stahel, PF Stahel, PF Stahel, PF Stahel, PH Yager, Q Shi, R Beschorner, R Knoth, RM Chesnut, RM Ransohoff, RS Ames, S Fumagalli, S Nataf, S Nataf, S Yang, SH Weerth, SK Ludwin, SL Kaczorowski, T Fujita, T Kossmann, TA Rupprecht, TJ Shors, U Amara, VM Holers, W Zheng, WH Kwan, X de la Rosa, X Jin, Y Chu, Y Rahpeymai, Y Xiong, YR Bogestål, Z You   +124 more
core   +1 more source

Reprogramming Immunogenicity of Iron Oxide Nanoparticles through Sulfated Glycan Presentation

Small, EarlyView.
This study presents a comparative analysis of heparin (HP)‐ and dextran sulfate (DS)‐coated superparamagnetic iron oxide nanoparticles (SPIONs) as a tunable immunomodulatory platform where surface chemistry dictates therapeutic function. DS‐SPIONs are preferentially internalized by myeloid cells, reprogramming them into a pro‐healing M2 phenotype ...
Negin Pournoori, Heela Sarlus, Dick J. Sjöström, Rohith Pavan Parvathaneni, Oommen P. Varghese, Vesa P. Hytönen, Robert A. Harris, Per H. Nilsson, Oommen P. Oommen   +8 more
wiley   +1 more source

An unexpected role for the anaphylatoxin C5a receptor in allergic sensitization [PDF]

Journal of Clinical Investigation, 2006
The anaphylatoxins complement component 3a and 5a (C3a and C5a, respectively) are classically seen as proinflammatory mediators of allergic asthma that recruit inflammatory cells, induce edema, and cause bronchoconstriction. A few years ago, controversy arose when it was shown that C5-deficient mice were more susceptible to experimental asthma compared
openaire   +2 more sources

Renal C3 complement component: feed forward to diabetic kidney disease [PDF]

, 2015
BACKGROUND: Diabetic nephropathy is the main cause of end-stage renal disease and has reached epidemic proportions. METHODS: Comprehensive genomic profiling (RNAseq) was employed in the ZS (F1 hybrids of Zucker and spontaneously hypertensive heart ...
Dominguez, Jesus H., Kelly, Katherine J., Liu, Yunlong, Zhang, Jizhong   +3 more
core   +2 more sources