Results 71 to 80 of about 6,562 (195)

Expression of C5a and its receptor in canine spontaneous tumours: a preliminary finding [PDF]

, 2016
A study of the development of spontaneous tumours in dogs gives many benefits in oncology research due to the similarity between dog and human cancer in terms of epidemiologic, biologic and clinical features.
Ahmad, Hafandi, Bachek, Noor Farhana, Ganti, Norhaifa, Kamarudin, Nurul Hazwani, Kosni, Nurneqman Nashreq, Md. Ajat, Mohd Mokrish, Mohd Noor, Mohd Hezmee, Selvarajah, Gayathri Thevi   +7 more
core  

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Emerging role of C5aR2: novel insights into the regulation of uterine immune cells during pregnancy

Frontiers in Immunology
Pregnancy is a fascinating immunological phenomenon because it allows allogeneic fetal and placental tissues to survive inside the mother. As a component of innate immunity with high inflammatory potential, the complement system must be tightly regulated
Fenna Froehlich, Konstanze Landerholm, Johanna Neeb, Ann-Kathrin Meß, Daniel Leonard Seiler, Tamara Tilburgs, Tamara Tilburgs, Christian Marcel Karsten   +7 more
doaj   +1 more source

Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment

mBio, 2018
Sepsis caused by Neisseria meningitidis (meningococcus) is a rapidly progressing, life-threatening disease. Because its initial symptoms are rather unspecific, medical attention is often sought too late, i.e., when the systemic inflammatory response is ...
Johannes B. Herrmann, Marcel Muenstermann, Lea Strobel, Alexandra Schubert-Unkmeir, Trent M. Woodruff, Scott D. Gray-Owen, Andreas Klos, Kay O. Johswich   +7 more
doaj   +1 more source

Adjunctive Therapies in Periodontitis: Current Concepts and the Future

Journal of Periodontal Research, EarlyView.
This graphical abstract summarizes the translational pathway from preclinical research to clinical implementation of adjunctive therapies for periodontitis, highlighting key barriers, innovative therapeutic strategies, and emerging tools that aim to bridge experimental discoveries with patient care.
Rafael Scaf de Molon, Joao Paulo Steffens, Erica Dorigatti de Avila, Wim Teughels, Thomas E. Van Dyke   +4 more
wiley   +1 more source

Expression and induction of anaphylatoxin C5a receptors in the rat liver.

Histology and histopathology, 2003
The C5a-anaphylatoxin which is generated by limited proteolysis upon activation of the fifth component of complement may be induced by the classical, the alternative or the lectin pathway. C5a has been shown, under normal conditions, to induce the release of prostanoids from Kupffer cells (KC) and hepatic stellate cells (HSC) and thereby indirectly to ...
Schlaf, G., Schmitz, M., Rothermel, E., Jungermann, K., Schieferdecker, H.L., Götze, O.   +5 more
openaire   +3 more sources

Identification of the Major Phosphorylation Sites in Human C5a Anaphylatoxin Receptor in Vivo [PDF]

Journal of Biological Chemistry, 1995
Interaction of human C5a anaphylatoxin with cell surface receptors mediates cell activation and receptor desensitization. Treatment of differentiated HL60 cells or transiently transfected COS-7 cells with C5a or phorbol 12-myristate 12-acetate (PMA) results in rapid hyperphosphorylation of the C5aR.
E, Giannini, L, Brouchon, F, Boulay
openaire   +2 more sources

Microbial neuraminidase induces a moderate and transient myelin vacuolation independent of complement system activation [PDF]

, 2017
Aims: Some central nervous system pathogens express neuraminidase (NA) on their surfaces. In the rat brain, a single intracerebroventricular (ICV) injection of NA induces myelin vacuolation in axonal tracts.
Agamanolis, Banizs, Bergmann, Bergmann, Bhatia, Bhole, Blakemore, Brew, Briggs, Bugiani, Casarsa, Collins, Collins, Corfield, Costa, Crocker, DeMarco, Donin, Duncan, Dyer, Ellison, Francis, Fruttiger, Fujita, Fuvesi, Gomez-Roldan, Granados-Duran, Granados-Duran, Granados-Duran, Greco, Grondona, Howe, Hundgeburth, Isfort, Ji, Johannes, Jubb, Karnovsky, Kelm, Klamm, Klos, Kreutzberg, Kurosawa, Langone, Leenaerts, Liberski, Love, Love, Malik, Marie, Matalon, Mead, Mead, Nardone, Nataf, Ortiz-Hidalgo, Ozkale, Pangburn, Peckham, Pernet, Pérez-Martín, Quarles, Ramaglia, Rollins, Roscoe, Rother, Schmued, Schnaar, Seto, Shibuta, Sonmez, Stoop, Strenge, Sturgill, Stys, Susuki, Szalardy, Tegla, Trapp, Trapp, Trapp, Urich, Vakeva, van der Lugt, van der Lugt, van Dixhoorn, Voudris, Vyas, Walis, Webster, Wells, Wetsel, Yang   +92 more
core   +1 more source

Spatial heterogeneity in microglia‐complement crosstalk: Implications for synaptic pruning in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by synaptic loss, as a key pathological feature in its early stages. Recent studies have highlighted the central role of microglia–complement interactions in synaptic pruning.
Qiuyan Ye, Wei Gao, Jiaping Feng, Xue Li, Jianhui Li, Fengge Yang, Linqing Li, Mingsheng Zi, Xinkai Wu, Hainan Gao, Honglin Li   +10 more
wiley   +1 more source

Cloning and preliminary pharmacological characterization of the anaphylatoxin C5a receptor in the rabbit [PDF]

British Journal of Pharmacology, 1999
The rabbit receptor for C5a was cloned from a genomic library and found to be 79.5% identical to the human homologue, the highest degree of similarity found so far in nonprimate laboratory animals. The rabbit C5a receptor stably expressed in RBL cells binds human 125I‐C5a (2 nM). Unlabelled C5a and the C‐terminal analogue N‐acetyl‐Tyr‐Ser‐Phe‐Lys‐Pro‐
D R, Bachvarov, S, Houle, M, Bachvarova, J, Bouthillier, S A, St-Pierre, Y, Fukuoka, J A, Ember, F, Marceau   +7 more
openaire   +2 more sources