Results 81 to 90 of about 6,562 (195)

Cancer epithelia-derived mitochondrial DNA is a targetable initiator of a paracrine signaling loop that confers taxane resistance. [PDF]

, 2020
Stromal-epithelial interactions dictate cancer progression and therapeutic response. Prostate cancer (PCa) cells were identified to secrete greater concentration of mitochondrial DNA (mtDNA) compared to noncancer epithelia.
Agarwal, Priyanka, Angara, Bryan, Bhowmick, Neil A, Billet, Sandrine, Duong, Frank, Haldar, Subhash, Madhav, Anisha, Mishra, Rajeev, Placencio-Hickok, Veronica R, Posadas, Edwin M, Thiruvalluvan, Manish, Tighiouart, Mourad   +11 more
core  

Bufalin Inhibits Cytokine Storm by Regulating TLR4/TLR3 Signaling Pathway

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Bufalin is one main component of the dried venom from Bufo gargarizans Cantor, which has anti‐tumor, cardiotonic, anti‐inflammatory and other physiological activities. However, in recent years, researchers have mainly paid attention to its anti‐tumor effect and neglected its anti‐inflammatory effect.
Xixi Liu, Chencheng Li, Jing Yang, Weiguang Zhang, Zhongxiao Hu, Xiaoli Zhang, Reaila Jianati, Fang Tian, Xingbin Dai, Zuqiong Xu, Biqing Chen, Xuejun Zhu   +11 more
wiley   +1 more source

Crosstalk between TGF-β1 and complement activation augments epithelial injury in pulmonary fibrosis [PDF]

, 2014
The epithelial complement inhibitory proteins (CIPs) cluster of differentiation 46 and 55 (CD46 and CD55) regulate circulating immune complex-mediated complement activation in idiopathic pulmonary fibrosis (IPF). Our previous studies demonstrated that IL-
Cummings, Oscar W., Gracon, Adam, Gu, Hongmei, Mickler, Elizabeth A., Sandusky, George E., Vittal, Ragini, Weber, Daniel J., Wilkes, David S., Woodruff, Trent   +8 more
core   +1 more source

Mechanisms of Immune Evasion, Dissemination, and Persistence in Leishmania amazonensis Infection

Parasite Immunology, Volume 48, Issue 1, January 2026.
ABSTRACT Leishmania amazonensis is one of the etiological agents of cutaneous leishmaniasis in its localised form. Moreover, this parasite can cause more severe disease conditions, such as diffuse and disseminated cutaneous leishmaniasis. The development of more severe clinical manifestations is associated with the parasite's ability to establish a ...
Arieli Bernardo Portugal, Renato Augusto DaMatta, Edézio Ferreira da Cunha Júnior, João Luiz Mendes Wanderley   +3 more
wiley   +1 more source

Anaphylatoxin C5a Regulates 6-Sulfo-LacNAc Dendritic Cell Function in Human through Crosstalk with Toll-Like Receptor-Induced CREB Signaling

Frontiers in Immunology, 2017
Activation of antigen-presenting dendritic cells (DCs) and the complement system are essential early events in the immune defense against invading pathogens.
Anouk Zaal, Anouk Zaal, Miranda Dieker, Miranda Dieker, Manon Oudenampsen, Manon Oudenampsen, Annelies W. Turksma, Annelies W. Turksma, Suzanne N. Lissenberg-Thunnissen, Suzanne N. Lissenberg-Thunnissen, Diana Wouters, Diana Wouters, S. Marieke van Ham, S. Marieke van Ham, Anja ten Brinke, Anja ten Brinke   +15 more
doaj   +1 more source

Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]

, 2020
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P., Leuvenink, Henri G. D., Nieuwenhuijs-Moeke, Gertrude J., Pischke, Soren E., Ploeg, Rutger J., Pol, Robert A., Sanders, Jan Stephan F., Struys, Michel   +7 more
core   +2 more sources

JAK Inhibitors as a Novel Approach to Autoimmune Bullous Diseases: A Review

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Autoimmune bullous diseases (AIBDs) are a group of chronic disorders characterized by blister formation resulting from abnormal immune responses. Janus kinase (JAK) inhibitors have emerged as promising therapeutic agents for AIBDs. This review discusses the use of JAK inhibitors—such as upadacitinib, baricitinib, tofacitinib, and abrocitinib, among ...
Olga Olisova, Yuliya Kolesova, Natalia Teplyuk, Ekaterina Grekova, Leyi Ni, Alina Mardanova, Karim Karray, Anastasiia Tikhonova, Anfisa Lepekhova, Jaime Piquero-Casals   +9 more
wiley   +1 more source

Demonstration of a specific receptor for human C5a anaphylatoxin on murine macrophages. [PDF]

The Journal of experimental medicine, 1982
Human C5a anaphylatoxin is known to be a potent mediator of the acute inflammatory response. It serves to trigger a wide variety of neutrophil responses after binding to a specific cellular receptor. We have now demonstrated that this bioactive glycopolypeptide is also bound to a specific receptor found on murine resident peritoneal macrophages ...
Chenoweth, D E, Goddman, M G, Weigle, W O   +2 more
openaire   +2 more sources

The Impact of Monkeypox Virus Infection on Pregnancy Outcome: Clinical Features and Potential Pathogenic Mechanisms

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Monkeypox has garnered significant attention following its emergence in multiple countries and its designation as a global health emergency in 2022. There is a notable deficiency in clinical and experimental data regarding pregnancy outcomes following monkeypox infection.
Jingyi Wu, Fangbin Huang, Qingliang Zheng, Poorani Gurumallesh   +3 more
wiley   +1 more source

C5 Variant rs10985126 is Associated with Mortality in Patients with Symptomatic Coronary Artery Disease

Pharmacogenomics and Personalized Medicine, 2021
Jessica Kristin Henes,1,* Patrick Groga-Bada,1,* Elke Schaeffeler,2,3 Stefan Winter,2,3 Luis Hack,1 Monika Zdanyte,1 Karin Mueller,1 Michal Droppa,1 Fabian Stimpfle,1 Meinrad Gawaz,1 Harald Langer,4 Matthias Schwab,2,3,5,6 Tobias Geisler,1 ...
Henes JK, Groga-Bada P, Schaeffeler E, Winter S, Hack L, Zdanyte M, Mueller K, Droppa M, Stimpfle F, Gawaz M, Langer H, Schwab M, Geisler T, Rath D   +13 more
doaj