Results 1 to 10 of about 10,701 (149)

NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild-Type Receptors: Identification of Highly Selective Inhibitors That Block the Process. [PDF]

FASEB J
CADASIL is the major cause of early‐onset stroke and cognitive dysfunction, including dementia. It is caused by mutations in the NOTCH3 receptor that result in the formation of protein aggregates in the small vessel walls of the brain. We demonstrated that NOTCH3 CADASIL variant receptor aggregation is strictly dependent on interactions with NOTCH3 ...
Wang H, Liu X, Gravesteijn G, Atella A, Liu J, Rutten JW, Ten Dijke P, Gonçalves MAFV, Lesnik Oberstein SAJ, Baker DA.   +9 more
europepmc   +2 more sources

Novel NOTCH3 alteration expanding the molecular spectrum of pericytic tumours: report of two cases. [PDF]

Histopathology
Introduction Myofibromas are part of the pericytic tumour family, which includes myopericytomas, glomus tumours and angioleiomyomas. While they typically display benign behaviour when arising in the skin and subcutaneous tissues of the head and neck, rare aggressive variants have been reported, particularly those with visceral or intracranial ...
Ungureanu IA, Le Quang M, Azmani R, Ancelle M, Margot H, Chotard G, Le Loarer F, Truffaux N.   +7 more
europepmc   +2 more sources

Synergistic effects of mutation and glycosylation on disease progression

Frontiers in Molecular Biosciences
Glycosylation, a post-translational modification, plays a crucial role in proper localization and function of proteins. It is regulated by multiple glycosyltransferases and can be influenced by various factors.
Shodai Suzuki, Motoyuki Itoh, Motoyuki Itoh, Motoyuki Itoh   +3 more
doaj   +1 more source

NOTCH3 attenuates cytotoxicity via RBPJ-dependent PVR upregulation to influence immunotherapy outcomes in colorectal cancer. [PDF]

Front Immunol
Ma Q, Xu S, Ma N, Li K, Liu Y, Ma F.
europepmc   +1 more source

The NOTCH3 extracellular domain is a serum biomarker for pulmonary arterial hypertension. [PDF]

Nat Med
Hernandez M, Winicki NM, Puerta CD, Lakshminarayanan S, Zhang Y, Ramirez-Sanchez I, Besse CE, Liu L, Poch DS, Yuan JX, Shyy JY, Yu PB, Garcia JGN, Thistlethwaite PA.   +13 more
europepmc   +1 more source

Notch3 regulates pericyte phenotypic plasticity in colorectal cancer. [PDF]

Commun Biol
Chalkidi N, Stavropoulou A, Arvaniti VZ, Paraskeva C, Monogyiou A, Sakkou M, Nikolaou C, Koliaraki V.   +7 more
europepmc   +1 more source

The dual role of the Notch signaling pathway in digestive system cancers. [PDF]

Eur J Med Res
Xiang D, Wang T, Wei S, Zhao R, Li L, Lu J.   +5 more
europepmc   +1 more source

Reduced SUMOylation impairs NOTCH3 signaling and cell survival in the pathogenesis of CADASIL. [PDF]

Cell Commun Signal
Long L, Wu D, Xiong X, Xiong H, Qiu X, Ping S.   +5 more
europepmc   +1 more source

Genetic depletion or pharmacological degradation of EZH2 attenuates renal fibrosis via suppressing Notch signaling. [PDF]

Clin Epigenetics
Yu C, Yao L, Du X, Yu J, Wang Y, Hou X, Shen F, Liu N, Zhuang S.   +8 more
europepmc   +1 more source

Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells. [PDF]

J Exp Clin Cancer Res
Sabol HM, Paxton BC, Anloague A, Kaur J, Nester MR, Khan S, Smith J, Croucher PI, McDonald MM, Montgomery CO, Stambough JB, Barnes CL, Ambrogini E, Ebetino FH, Schinke C, Ashby C, Delgado-Calle J.   +16 more
europepmc   +1 more source