Results 91 to 100 of about 10,701 (149)

A Brain‐Targeting Curcumin Analog Inhibits Glioblastoma Progression Through THBS1/TGF‐β1/PI3K–AKT Axis Modulation: Evidence From Experimental and Bioinformatic Analyses

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Glioblastoma (GBM) is the most aggressive primary brain tumour, associated with a dismal prognosis and an urgent need for innovative therapeutic strategies. To address this challenge, our group developed DMC‐GF, a novel brain‐targeted curcumin analog engineered to enhance blood–brain barrier permeability by blocking metabolic sites and ...
Zijian Han, Xuetao Li, Yang Zhu, Zhimin Wang, Yingbo Hou, Huiling Tao, Meng Ma, Xiangtong Xie, HaiYang Zhang   +8 more
wiley   +1 more source

Proteomic insights into the invasiveness and tumor progression of non‐functioning pituitary adenomas: A scoping review

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract Nonfunctioning pituitary adenomas (NFPAs) are common intracranial tumors that, despite being histologically benign, can exhibit invasive growth, as well as postoperative tumor progression. Surgical resection is the primary treatment of choice; however, residual tumor tissue is frequently observed, with between 30% and 50% of these cases ...
Thomas Skoglund, Linus Köster, Annika Thorsell, Oskar Ragnarsson, Gudmundur Johannsson, Tobias Hallén   +5 more
wiley   +1 more source

Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation

Molecular Cancer, 2011
Background Pancreas cancer is one of most aggressive human cancers with the survival rate for patients with metastatic pancreas cancer at 5-6 months. The poor survival demonstrates a clear need for better target identification, drug development and new ...
Vo Kevin, Amarasinghe Barushi, Washington Kay, Gonzalez Adriana, Berlin Jordan, Dang Thao P   +5 more
doaj   +1 more source

Is the oxidant/antioxidant status altered in CADASIL patients?

PLoS ONE, 2013
The altered aggregation of proteins in non-native conformation is associated with endoplasmic reticulum derangements, mitochondrial dysfunction and excessive production of reactive oxygen species. Cerebral autosomal dominant arteriopathy with subcortical
Jonica Campolo, Renata De Maria, Caterina Mariotti, Chiara Tomasello, Marina Parolini, Marina Frontali, Domenico Inzitari, Raffaella Valenti, Antonio Federico, Franco Taroni, Oberdan Parodi   +10 more
doaj   +1 more source

Isolation and characterization of a new basal-like luminal progenitor in human breast tissue

Stem Cell Research & Therapy, 2019
Background Adult stem cells and progenitors are responsible for breast tissue regeneration. Human breast epithelial progenitors are organized in a lineage hierarchy consisting of bipotent progenitors (BPs), myoepithelial- and luminal-restricted ...
Vasudeva Bhat, Victoria Lee-Wing, Pingzhao Hu, Afshin Raouf   +3 more
doaj   +1 more source

易误诊为多发性硬化的伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病1例报道A Case Report of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Easily Misdiagnosed as Multiple Sclerosis

Zhongguo cuzhong zazhi
伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病（cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy，CADASIL）是一种常染色体显性遗传性脑小血管疾病。多发性硬化是一种中枢神经系统的炎症性脱髓鞘疾病。两者在临床表现和影像学特征上有较多类似之处，易造成误诊。本文报道１例因颅内和脊髓同时发生病变，最初诊断为多发性硬化，最终经基因检测明确诊断为Notch受体3（Notch ...
吴慧敏, 游咏, 陈斌WU Huimin, YOU Yong, CHEN Bin
doaj   +1 more source

Advances in induced pluripotent stem cell-based disease modeling for rare neurodegenerative disease: A narrative review [PDF]

Precision and Future Medicine
Understanding the genetic basis and pathomechanisms underlying dementia arising from single-gene mutations is crucial to expand our knowledge in the field of dementia research. In this review, we comprehensively summarize the results of existing research
Seung-yeon Lee, Hyo Jin Son, Sang Won Seo, Duk L. Na, Hee Jin Kim   +4 more
doaj   +1 more source

Bladder Cancer: Uncovering the Predictive Role of NOTCH as an Emerging Candidate Biomarker for Therapeutic Strategies. [PDF]

Cancers (Basel)
Cusumano C, Squillante F, Roma M, Miano R, Felli MP.   +4 more
europepmc   +1 more source

Necessity of Notch3 signaling in myofiber maturation in a pluripotent stem cell transplant model. [PDF]

Skelet Muscle
Yamashita AMS, Crist SB, Garay BI, Kim H, Azzag K, Bosnakovski D, Faria SHDM, Abrahante JE, Abreu P, Ahlquist A, Perlingeiro RCR.   +10 more
europepmc   +1 more source

Genotype-phenotype correlations in a Scottish CADASIL cohort and comparison with sporadic small vessel disease. [PDF]

Eur Stroke J
Neilson SJ, Boadu W, Sitaram A, Davidson R, Moreton F, Dickie DA, Dawson J, Muir KW.   +7 more
europepmc   +1 more source