Results 11 to 20 of about 10,701 (149)

NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells [PDF]

Cell Reports Medicine, 2021
Summary: Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive.
Kenneth G. Geles, Yijie Gao, Andreas Giannakou, Latha Sridharan, Ting-Ting Yamin, Jing Zhang, Riyez Karim, Joel Bard, Nicole Piche-Nicholas, Manoj Charati, Andreas Maderna, Judy Lucas, Jonathon Golas, Magali Guffroy, Steven Pirie-Shepherd, Marc Roy, Jessie Qian, Tania Franks, Wenyan Zhong, Christopher J. O’Donnell, Lioudmila Tchistiakova, Hans-Peter Gerber, Puja Sapra   +22 more
doaj   +3 more sources

CADASIL or NOTCH3 mutaion spectrum diseases? Interpretation of NOTCH3 mutations and clinical heterogeneity in CADASIL [PDF]

Frontiers in Neurology
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal dominant disorder characterized by midlife-onset cerebrovascular disease and dementia.
Yuehui Wang, Yiran Liu, Hongbin Mo, Yue Han, Yuanyuan Jing, Fang Deng   +5 more
doaj   +2 more sources

HCMV promotes viral reactivation through the coordinated regulation of Notch signaling by UL8 and miR-UL36 [PDF]

mBio
Human cytomegalovirus (HCMV) establishes latency in CD34+ hematopoietic progenitor cells (HPCs), where reactivation is intimately linked to cellular differentiation.
Aaron Dirck, Nicole Diggins, Wilma Perez, Christopher Parkins, Michael Daily, Rebekah L. Turner, Luke Slind, Linh Nguyen, Daniel Malouli, Guanming Wu, Meaghan Hancock, Patrizia Caposio   +11 more
doaj   +2 more sources

The Relationship between TSG101 Protein and Notch3 Receptor in Lung Cancer

Chinese Journal of Lung Cancer, 2009
Background and objective TSG101 protein is one of the key factors in Endosomal sorting pathway. The abnormality of this pathway could decrease degradation of Notch receptor which leads to disorder of cell differentiation and development in drosophila. In
Jiahui CHANG, Ping LU, Cunwei CAI,, Fei LI, Zhiyong ZHONG, Daorong ZHANG   +5 more
doaj   +2 more sources

Role of Notch gene receptors as prognostic biomarkers in colorectal cancer [PDF]

Scientific Reports
The incidence of colorectal cancer (CRC) is increasing across the world, especially in younger age groups and the Indian subcontinent. Dysregulation in Notch pathway genes and their Single Nucleotide Polymorphism (SNPs) can potentially lead to aberrant ...
Abhay Kumar Sharma, Nimisha Nimisha, Arun Kumar, Apurva Apurva, Abhishek Kumar, Ejaj Ahmad, Asgar Ali, Birendra Prasad, Sundeep Singh Saluja   +8 more
doaj   +2 more sources

The aggressive colorectal cancer subtype marker HTR2B has a dual role depending on the tumor microenvironment [PDF]

Cell Communication and Signaling
Colorectal cancer (CRC) is the second-third most frequent cancer type in the Western countries, with significant inter- and intra-patient cellular heterogeneity.
Idan Carmi, Adrián Orosz, Szabolcs Hajdó, Anikó Zeöld, Tamás Hegedűs, Dóra Kelemen-Győri, Julianna Pozsár, Tamás Tölgyes, Zoltán Wiener   +8 more
doaj   +2 more sources

Fibrosis and Immune Cell Infiltration Are Separate Events Regulated by Cell-Specific Receptor Notch3 Expression. [PDF]

J Am Soc Nephrol, 2020
Significance StatementIn patients with CKD, receptor Notch3 is strongly upregulated. Conversely, in experimental kidney disease models,Notch3deficiency protects from organ damage. To determine whether Notch3 on immune cells or tissue-resident cells participates in the inflammatory response, animals with bone marrow chimerism were generated.
Brandt S, Ballhause TM, Bernhardt A, Becker A, Salaru D, Le-Deffge HM, Fehr A, Fu Y, Philipsen L, Djudjaj S, Müller AJ, Kramann R, Ibrahim M, Geffers R, Siebel C, Isermann B, Heidel FH, Lindquist JA, Mertens PR.   +18 more
europepmc   +6 more sources

Androgen receptor inhibitor ameliorates pulmonary arterial hypertension by enhancing the apoptosis level through suppressing the Notch3/Hes5 pathway

Frontiers in Pharmacology
BackgroundPulmonary arterial hypertension (PAH) exhibits significant gender differences in prognosis, with male patients typically showing worse outcomes than females.
Jiayan Sun, Jiayan Sun, Jiayan Sun, Jiancheng Lin, Jiancheng Lin, Jiancheng Lin, Di Yin, Di Yin, Di Yin, Zetao Pan, Zetao Pan, Zetao Pan, Yuheng Ye, Yuheng Ye, Yuheng Ye, Yi Wang, Yi Wang, Yi Wang, Xiaowan Wang, Xiaowan Wang, Xiaowan Wang, Qiang Guo, Qiang Guo, Qiang Guo, Qiang Guo   +24 more
doaj   +3 more sources

The Role of Notch3 Signaling in Cancer Stemness and Chemoresistance: Molecular Mechanisms and Targeting Strategies

Frontiers in Molecular Biosciences, 2021
Aberrant Notch signaling profoundly affects cancer progression. Especially the Notch3 receptor was found to be dysregulated in cancer, where its expression is correlated with worse clinicopathological features and poor prognosis. The activation of Notch3
Mengxi Xiu, Mengxi Xiu, Yongbo Wang, Yongbo Wang, Baoli Li, Baoli Li, Xifeng Wang, Fan Xiao, Fan Xiao, Shoulin Chen, Shoulin Chen, Lieliang Zhang, Lieliang Zhang, Bin Zhou, Bin Zhou, Fuzhou Hua, Fuzhou Hua   +16 more
doaj   +1 more source

Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins [PDF]

Molecular and Cellular Biology, 2014
In mammals, there are four NOTCH receptors and five Delta-Jagged-type ligands regulating many aspects of embryonic development and adult tissue homeostasis. NOTCH proteins are type I transmembrane receptors that interact with ligands on adjacent cells and are activated by regulated intramembrane proteolysis (RIP).
Groot, Arjan J., Habets, Roger, Yahyanejad, Sanaz, Hodin, Caroline M., Reiss, Karina, Saftig, Paul, Theys, Jan, Vooijs, Marc   +7 more
openaire   +3 more sources