Results 21 to 30 of about 10,701 (149)

The emerging role of NOTCH3 receptor signalling in human lung diseases

Expert Reviews in Molecular Medicine, 2022
Abstract The mammalian respiratory system or lung is a tree-like branching structure, and the main site of gas exchange with the external environment. Structurally, the lung is broadly classified into the proximal (or conducting) airways and the distal alveolar region, where the gas exchange occurs.
Manish Bodas, Bharathiraja Subramaniyan, Harry Karmouty-Quintana, Peter F. Vitiello, Matthew S. Walters   +4 more
openaire   +2 more sources

The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression

Disease Models & Mechanisms, 2021
Infantile myofibromatosis (IMF) is a benign tumor form characterized by the development of nonmetastatic tumors in skin, bone, muscle and sometimes viscera. Autosomal-dominant forms of IMF are caused by mutations in the PDGFRB gene, but a family carrying
Dan Wu, Sailan Wang, Daniel V. Oliveira, Francesca Del Gaudio, Michael Vanlandewijck, Thibaud Lebouvier, Christer Betsholtz, Jian Zhao, ShaoBo Jin, Urban Lendahl, Helena Karlström   +10 more
doaj   +1 more source

Expressions and Prognostic Values of Notch3 and DLL4 in Human Breast Cancer

Technology in Cancer Research & Treatment, 2023
Background : Notch signaling played a critical role in promoting breast tumorigenesis and progression. However, the role and prognostic value of Notch3 combined with DLL4 expression in breast carcinoma had not been explored.
Lin Wang, Ge Cao, Wei Li, Xiao-Wen Chen, Shi-Shuang Xiong, Ya-Nan Mu, Jin-Fang Jiang, Lan Yang, De-Rui Zhang, Yu-Wen Cao   +9 more
doaj   +1 more source

NOTCH3 limits the epithelial–mesenchymal transition and predicts a favorable clinical outcome in esophageal cancer

Cancer Medicine, 2021
Background Esophageal squamous cell carcinoma (ESCC) is the deadliest of all human squamous cell carcinomas and is characterized by chemotherapy resistance and poor prognosis associated with the epithelial–mesenchymal transition (EMT).
Norihiro Matsuura, Koji Tanaka, Makoto Yamasaki, Kotaro Yamashita, Takuro Saito, Tomoki Makino, Kazuyoshi Yamamoto, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Hidetoshi Eguchi, Hiroshi Nakagawa, Yuichiro Doki   +12 more
doaj   +1 more source

The association between NOTCH3 expression and the clinical outcome in the urothelial bladder cancer patients

Biomolecules & Biomedicine, 2022
Disrupted NOTCH activity is a driving event in urothelial bladder cancer (UBC). After activation by hypoxia, the NOTCH3 receptor participates in tumor cell proliferation, acquisition of the epithelial-mesenchymal transition phenotype, and angiogenesis ...
Ana Ristic Petrovic, Dragana Stokanović, Slavica Stojnev, Milena Potić Floranović, Miljan Krstić, Ivana Djordjević, Aleksandar Skakić, Ljubinka Janković Veličković   +7 more
doaj   +1 more source

The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients [PDF]

Journal of Clinical Investigation, 2000
Mutations in Notch3 cause CADASIL (cerebral autosomal dominant adult onset arteriopathy), which leads to stroke and dementia in humans. CADASIL arteriopathy is characterized by major alterations of vascular smooth muscle cells and the presence of specific granular osmiophilic deposits.
Joutel, A, Andreux, F, Gaulis, S, Domenga, V, Cecillon, M, Battail, N, Piga, N, Chapon, F, Godfrain, C, Tournier-Lasserve, E   +9 more
openaire   +3 more sources

Activation Dynamics and Signaling Properties of Notch3 Receptor in the Developing Pulmonary Artery [PDF]

Journal of Biological Chemistry, 2011
Notch3 signaling is fundamental for arterial specification of systemic vascular smooth muscle cells (VSMCs). However, the developmental role and signaling properties of the Notch3 receptor in the mouse pulmonary artery remain unknown. Here, we demonstrate that Notch3 is expressed selectively in pulmonary artery VSMCs, is activated from late fetal to ...
Shamik, Ghosh, Jesus R, Paez-Cortez, Karthik, Boppidi, Michelle, Vasconcelos, Monideepa, Roy, Wellington, Cardoso, Xingbin, Ai, Alan, Fine   +7 more
openaire   +2 more sources

Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model

EMBO Molecular Medicine, 2022
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of familial small vessel disease; no preventive or curative therapy is available. CADASIL is caused by mutations in the
Daniel V Oliveira, Kirsten G Coupland, Wenchao Shao, Shaobo Jin, Francesca Del Gaudio, Sailan Wang, Rhys Fox, Julie W Rutten, Johan Sandin, Henrik Zetterberg, Johan Lundkvist, Saskia AJ Lesnik Oberstein, Urban Lendahl, Helena Karlström   +13 more
doaj   +1 more source

Notch2 and Notch3 function together to regulate vascular smooth muscle development. [PDF]

PLoS ONE, 2012
Notch signaling has been implicated in the regulation of smooth muscle differentiation, but the precise role of Notch receptors is ill defined. Although Notch3 receptor expression is high in smooth muscle, Notch3 mutant mice are viable and display only ...
Qingqing Wang, Ning Zhao, Simone Kennard, Brenda Lilly   +3 more
doaj   +1 more source

Genetic study of the NOTCH3 gene in CADASIL patients

Egyptian Journal of Medical Human Genetics, 2018
Background: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic, hereditary, neurological syndrome characterized by small vessel disease (SVD), stroke, vascular cognitive impairment and ...
Seyedeh Parisa Chavoshi Tarzjani, Seyed Abolhassan Shahzadeh Fazeli, Mohammad Hossein Sanati, Zahra Mirzayee   +3 more
doaj   +1 more source