Results 31 to 40 of about 10,701 (149)

Low Density Lipoprotein Receptor-related Protein-1 (LRP1) Regulates Thrombospondin-2 (TSP2) Enhancement of Notch3 Signaling [PDF]

Journal of Biological Chemistry, 2010
Intracellular trafficking of Notch and Notch ligands modulates signaling, suggesting that choreography of ligand and receptor translocation is essential for optimal Notch activity. Indeed, a major model for Notch signaling posits that Notch trans-endocytosis into the ligand-expressing (signal sending) cell is a key driving force for Notch signal ...
He, Meng, Xiaojie, Zhang, Soo Jung, Lee, Dudley K, Strickland, Daniel A, Lawrence, Michael M, Wang   +5 more
openaire   +2 more sources

Notch3 Knockout Suppresses Mouse Mammary Gland Development and Inhibits the Proliferation of 4T1 Murine Mammary Carcinoma Cells via CCL2/CCR4 Axis

Frontiers in Cell and Developmental Biology, 2020
Our previous study found that Notch3 knockout mice exhibit defects in mammary gland development. To elucidate the underlying mechanism, tissue samples were subjected to RNA-seq, GO, and KEGG enrichment analyses and qRT-PCR validation.
Wei Xiong, Junyu Tan, Yuxian Guo, Shuzhao Chen, Liping Fan, Yaochen Li, Yaochen Li   +6 more
doaj   +1 more source

Notch receptor expression in neurogenic regions of the adult zebrafish brain. [PDF]

PLoS ONE, 2013
The adult zebrash brain has a remarkable constitutive neurogenic capacity. The regulation and maintenance of its adult neurogenic niches are poorly understood.
Vanessa de Oliveira-Carlos, Julia Ganz, Stefan Hans, Jan Kaslin, Michael Brand, Michael Brand   +5 more
doaj   +1 more source

Dominant-Negative Notch3 Receptor Inhibits Mitogen-Activated Protein Kinase Pathway and the Growth of Human Lung Cancers [PDF]

Cancer Research, 2005
Abstract Notch3 is a member of an evolutionarily conserved family of cell surface receptors important in cell-fate determination in both vertebrates and invertebrates. Significant data support the role of Notch pathway in cancer development, although the conflicting role of Notch signaling pathways in tumorigenesis suggests that its ...
Nobuhiro, Haruki, Keiko S, Kawaguchi, Shannon, Eichenberger, Pierre P, Massion, Sandra, Olson, Adriana, Gonzalez, David P, Carbone, Thao P, Dang   +7 more
openaire   +2 more sources

Immobilization of Jagged1 Enhances Vascular Smooth Muscle Cells Maturation by Activating the Notch Pathway

Cells, 2021
In Notch signaling, the Jagged1-Notch3 ligand-receptor pairing is implicated for regulating the phenotype maturity of vascular smooth muscle cells. However, less is known about the role of Jagged1 presentation strategy in this regulation.
Kathleen Zohorsky, Shigang Lin, Kibret Mequanint   +2 more
doaj   +1 more source

The Skeleton of Lateral Meningocele Syndrome

Frontiers in Genetics, 2021
Notch (Notch1 through 4) are transmembrane receptors that determine cell differentiation and function, and are activated following interactions with ligands of the Jagged and Delta-like families.
Ernesto Canalis
doaj   +1 more source

Clinical and epidemiological profiles from a case series of 26 Brazilian CADASIL patients

Arquivos de Neuro-Psiquiatria, 2023
Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetic cause of ischemic stroke and the most common form of non-atherosclerotic stroke.
Renata Nogueira, Christian Marques Couto, Pérola de Oliveira, Bernardo José Alves Ferreira Martins, Vinícius Viana Abreu Montanaro   +4 more
doaj   +1 more source

Nuclear orphan receptor NR2F6 confers cisplatin resistance in epithelial ovarian cancer cells by activating the Notch3 signaling pathway [PDF]

International Journal of Cancer, 2019
The primary challenge facing treatment of epithelial ovarian cancer (EOC) is the high frequency of chemoresistance, which severely impairs the quality of life and survival of patients with EOC. Our study aims to investigate the mechanisms by which upregulation of NR2F6 induces chemoresistance in EOC. The biological roles of NR2F6 in EOC chemoresistance
Han Li, Weijing Zhang, Chunhao Niu, Chuyong Lin, Xianqiu Wu, Yunting Jian, Yue Li, Liping Ye, Yuhu Dai, Ying Ouyang, Jueming Chen, Jiaqi Qiu, Libing Song, Yanna Zhang   +13 more
openaire   +2 more sources

Analysis of the expression of the Notch3 receptor protein in adult lung cancer

Oncology Letters, 2012
Abnormalities in the Notch signaling system are considered to play a role in the tumorigenesis of bronchiogenic carcinoma. The present study aimed to investigate the expression of Notch3 in adult lung cancer patients and its role in the pathogenesis of primary bronchiogenic carcinoma. The expression of the Notch3 protein in lung squamous cell carcinoma,
ZHOU, MIN, JIN, WEI-YUN, FAN, ZHI-WEN, HAN, RUI-CHAO   +3 more
openaire   +3 more sources

Prevalence and Atypical Clinical Characteristics of NOTCH3 Mutations Among Patients Admitted for Acute Lacunar Infarctions

Frontiers in Aging Neuroscience, 2020
Objectives: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary small vessel disease, with reported frequencies of 2-5/100,000 individuals. Recently, it has been reported that
Takashi Okada, Kazuo Washida, Kenichi Irie, Satoshi Saito, Satoshi Saito, Michio Noguchi, Tsutomu Tomita, Masatoshi Koga, Kazunori Toyoda, Shuhei Okazaki, Takashi Koizumi, Ikuko Mizuta, Toshiki Mizuno, Masafumi Ihara   +13 more
doaj   +1 more source