Results 41 to 50 of about 10,701 (149)

Bruceine H Mediates EGFR-TKI Drug Persistence in NSCLC by Notch3-Dependent β-Catenin Activating FOXO3a Signaling

Frontiers in Oncology, 2022
Tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR) protein serve as a critical pillar in the treatment of non-small cell lung cancer (NSCLC), but resistance is universal.
Jiahui Wu, Xiao He, Ziwei Xiong, Lingyu Shi, Daofeng Chen, Yulin Feng, Quan Wen   +6 more
doaj   +1 more source

CADASIL syndrome in a large Turkish kindred caused by the R90C mutation in the Notch3 receptor

European Journal of Neurology, 2002
Mutations in the Notch3 gene are the cause of the autosomal dominant disorder CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). The CADASIL is an adult‐onset neurologic disorder (average age of onset is 45 years) characterized by recurrent strokes and dementia. Clinical features combined with cerebral
Utku, U, Celik, Y, Uyguner, O, Yüksel-Apak, M, Wollnik, B   +4 more
openaire   +3 more sources

The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation

Cells, 2021
Basal cells (BCs) are stem/progenitor cells of the mucociliary airway epithelium, and their differentiation is orchestrated by the NOTCH signaling pathway.
Manish Bodas, Bharathiraja Subramaniyan, Andrew R. Moore, Jordan P. Metcalf, Sarah R. Ocañas, Willard M. Freeman, Constantin Georgescu, Jonathan D. Wren, Matthew S. Walters   +8 more
doaj   +1 more source

Overexpression of the Notch3 receptor and its ligand Jagged1 in human clinically non-functioning pituitary adenomas

Oncology Letters, 2013
Human clinically non-functioning pituitary adenomas (NFPAs) primarily cause headaches, visual impairment and hypopituitarism due to the effect of the mass of the tumor. Surgery is the first-line treatment for these tumors. To date, no efficacious medical therapy exists for non-functioning adenomas.
LU, RUNCHUN, GAO, HUA, WANG, HONGYUN, CAO, LEI, BAI, JIWEI, ZHANG, YAZHUO   +5 more
openaire   +3 more sources

Sepsis downregulates aortic Notch signaling to produce vascular hyporeactivity in mice

Scientific Reports, 2022
Inhibition of Notch signaling in macrophages is known to reduce inflammation, however, its role in regulating vascular hyporeactivity in sepsis is unknown. Thus we aimed to evaluate the effect of sepsis on vascular Notch signaling.
Vandana Singh, Raut Akash, Gaurav Chaudhary, Rajneesh Singh, Soumen Choudhury, Amit Shukla, Shyama N. Prabhu, Neeraj Gangwar, Satish K. Garg   +8 more
doaj   +1 more source

Pathological changes and molecular ⁃ genetic mechanisms of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a inherited cerebral small vessel disease caused by Notch3 gene mutation. The molecular⁃genetic mechanisms of CADASIL have been still unclear.
SUN Yuan⁃jing, FAN Yu⁃hua
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Novel mechanism of resistance to targeted therapies in lung cancer

Molecular & Cellular Oncology, 2019
We have identified a non-canonical role of0 Notch3 in response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy, whereby Notch3 associates with β-catenin, resulting in increased catenin beta-1 (CTNNB1, best known as β ...
Walter Wang, David P. Carbone, Rajeswara Rao Arasada   +2 more
doaj   +1 more source

SUSD2 Promotes Metastasis and Primary Tumor Growth in Pancreatic Cancer Cells via Integrin-FAK Signaling Activation. [PDF]

Cancer Sci
This study investigates the role of Sushi domain‐containing 2 (SUSD2) in pancreatic ductal adenocarcinoma (PDAC) and demonstrates that SUSD2 enhances both metastasis and primary tumor growth by promoting integrin β1–FAK signaling. SUSD2 interacts with integrin β1, enhancing adhesion to extracellular matrix (ECM) components such as collagen 1 and ...
Yoshida J, Ohishi T, Momose I, Ohba SI, Kurosawa K, Harakawa A, Inoue H, Senoo M, Tatsuda D, Abe H, Masamune A, Kawada M.   +11 more
europepmc   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source