Results 91 to 100 of about 22,802 (228)

trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT2 receptor family

Beilstein Journal of Organic Chemistry, 2012
A strategy to replace the ethylamine side chain of 2,5-dimethoxy-4-iodoamphetamine (DOI, 1a), and 2,5-dimethoxy-4-bromoamphetamine (DOB, 1b) with a cyclopropylamine moiety was successful in leading to compounds with high affinity at the 5-HT2 family of ...
Adam Pigott, Stewart Frescas, John D. McCorvy, Xi-Ping Huang, Bryan L. Roth, David E. Nichols   +5 more
doaj   +1 more source

New Imide 5-HT1A Receptor Ligands – Modification of Terminal Fragment Geometry

Molecules, 2004
Two sets of new o-methoxyphenylpiperazine (MPP; series a) and 1,2,3,4-tetrahydroisoquinoline (THIQ; series b) derivatives, containing various imide moietiesderived from NAN190, were synthesized and evaluated in vitro for their ability to bind tothe ...
Ryszard Bugno, Aneta Kozioł, Beata Duszyńska, Maria J. Mokrosz, Andrzej J. Bojarski   +4 more
doaj   +1 more source

Central serotonin2C receptor : from physiology to pathology [PDF]

, 2006
Since the 1950s, when serotonin (5-HT) was discovered in the mammalian central nervous system (CNS), an enormous amount of experimental evidence has revealed the pivotal role of this biogenic amine in a number of cognitive and behavioural functions ...
Benigno, Arcangelo, Di Giovanni, Giuseppe, Esposito, Ennio, Matteo, Vincenzo di, Pierucci, Massimo   +4 more
core   +1 more source

The Viloxazine Paradox: A Noradrenergic Agent's Journey From Antidepressant Obscurity to ADHD Precision Therapy

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
Viloxazine, a serotonin–norepinephrine modulating agent, has been repurposed from an antidepressant to a novel non‐stimulant for ADHD. Its multimodal mechanism and Phase II/III trials demonstrate clinically meaningful symptom reduction with a distinct safety and interaction profile, offering an alternative for patients who cannot tolerate stimulants ...
Ghaith K. Mansour, Sabry Babiker H. Sayed, Sajjad Ghanim Al‐Badri, Mohammed Gamaleldin Abdulrahim Abdalla, Dina Essam Abo‐elnour   +4 more
wiley   +1 more source

A Single Dose of LSD Does Not Alter Gene Expression of the Serotonin 2A Receptor Gene (HTR2A) or Early Growth Response Genes (EGR1-3) in Healthy Subjects

Frontiers in Pharmacology, 2017
Rationale: Renewed interest has been seen in the use of lysergic acid diethylamide (LSD) in psychiatric research and practice. The repeated use of LSD leads to tolerance that is believed to result from serotonin (5-HT) 5-HT2A receptor downregulation.
Patrick C. Dolder, Edna Grünblatt, Edna Grünblatt, Edna Grünblatt, Felix Müller, Stefan J. Borgwardt, Matthias E. Liechti   +6 more
doaj   +1 more source

Influence of mirtazapine on salivary cortisol in depressed patients [PDF]

, 2003
Unlike other antidepressants, mirtazapine does not inhibit the reuptake of norepinephrine or serotonin but acts as an antagonist at presynaptic alpha(2)-receptors, at postsynaptic 5-HT2 and 5-HT3 receptors, and at histaminergic H1 receptors. Furthermore,
Baghai, Thomas C., Hennig, J., Laakmann, G., Schule, C.   +3 more
core   +1 more source

Predicting Long‐Term Depression Progression in Parkinson's Disease: A Machine‐Learning Survival Analysis and Risk Score

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
We developed and internally validated a machine learning–based survival model for predicting long‐term progression of dPD. Supported by SHAP analysis, the model identified that depressive symptom severity, cognitive impairment, and autonomic dysfunction were the main key clinical predictors for dPD progression.
Defu Liu, Chong Qi, Jiansong Huang, Hutao Xie, Yutong Zhuang, Quan Zhang, Xuemin Zhao, Tianqi Hu, Guofan Qin, Yue Lu, Xin Zhang, Sizhe Li, Mingyu Yang, Jianguo Zhang, Yin Jiang   +14 more
wiley   +1 more source

Withdrawal from chronic alcohol impairs the serotonin-mediated modulation of GABAergic transmission in the infralimbic cortex in male rats

Neurobiology of Disease
The infralimbic cortex (IL) is part of the medial prefrontal cortex (mPFC), exerting top-down control over structures that are critically involved in the development of alcohol use disorder (AUD).
Roman Vlkolinsky, Sophia Khom, Valentina Vozella, Michal Bajo, Marisa Roberto   +4 more
doaj   +1 more source

Repeated Clozapine Increases the Level of Serotonin 5-HT1AR Heterodimerization with 5-HT2A or Dopamine D2 Receptors in the Mouse Cortex

Frontiers in Molecular Neuroscience, 2018
G-protein–coupled receptor (GPCR) heterodimers are new targets for the treatment of schizophrenia. Dopamine D2 receptors and serotonin 5-HT1A and 5-HT2A receptors play an important role in neurotransmission and have been implicated in many human ...
Marta Szlachta, Maciej Kuśmider, Paulina Pabian, Joanna Solich, Magdalena Kolasa, Dariusz Żurawek, Marta Dziedzicka-Wasylewska, Agata Faron-Górecka   +7 more
doaj   +1 more source

Unraveling monoamine receptors involved in the action of typical and atypical antipsychotics on glutamatergic and serotonergic transmission in prefrontal cortex [PDF]

, 2013
El pdf del artículo es la versión post-print.The systemic administration of noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists has been considered as a pharmacological model of schizophrenia.
Adell, Albert, Artigas, Francesc, López-Gil, Xavier   +2 more
core   +2 more sources