Results 81 to 90 of about 12,430 (191)

Comparative Sleep Architecture Profiles of Antidepressants in Mice: Pharmacological Characterization of Paroxetine, Sertraline, Duloxetine, Mirtazapine and Vortioxetine

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
This study compared five antidepressants (paroxetine, sertraline, duloxetine, mirtazapine, and vortioxetine) in mice using EEG/EMG, revealing distinct effects on REM and NREM sleep. The figure illustrates changes in sleep architecture during the light phase (ZT0–12).
Junya Maruoka, Ryo Egami, Yuto Akita, Kohei Kozuka, Yusuke Kakumoto, Tetsuro Kikuchi, Kazuhiko Kume   +6 more
wiley   +1 more source

Puerarin Acts Through Brain Serotonergic Mechanisms to Induce Thermal Effects

Journal of Pharmacological Sciences, 2004
The present study was attempted to investigate the effect of puerarin, an isoflavone compound isolated from Pueraria lobata, on both the basal body temperature and pyrogenic fever in unanesthetized, restrained rats.
Fu-Shin Chueh, Ching-Ping Chang, Chung-Ching Chio, Mao-Tsun Lin   +3 more
doaj   +1 more source

Hippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging

Addiction, Volume 121, Issue 6, Page 1541-1556, June 2026.
Abstract Background and aims Recreational ketamine use has increased globally and is associated with psychiatric and cognitive concerns. The hippocampus in preclinical models shows damage and working‐memory disruption with repeated dosing. However, whether specific hippocampal subregions may differ in people with chronic ketamine use remains unclear ...
Yi‐Hsuan Liu, Chia‐Chun Hung, Marc N. Potenza, Kun‐Hsien Chou, Pei‐Lin Lee, Chu‐Chung Huang, Chiang‐Shan R. Li, Tony Szu‐Hsien Lee, Ching‐Po Lin   +8 more
wiley   +1 more source

Biased signaling via serotonin 5-HT2A receptor: From structural aspects to in vitro and in vivo pharmacology

Acta Pharmaceutica Sinica B
G protein-coupled receptors (GPCRs) represent key drug targets, with approximately 30%–40% of all medications acting on these receptors. Recent advancements have uncovered the complexity of GPCR signaling, including biased signaling, which allows ...
Michał K. Jastrzębski, Piotr Wójcik, Angelika Grudzińska, Giorgia Andreozzi, Tommaso Vetrò, Ayesha Asim, Akanksha Mudgal, Jakub Czapiński, Tomasz M. Wróbel, Damian Bartuzi, Katarzyna M. Targowska-Duda, Agnieszka A. Kaczor   +11 more
doaj   +1 more source

Limited Associations Between 5-HT Receptor Gene Polymorphisms and Treatment Response in Antidepressant Treatment-Free Patients With Depression

Frontiers in Pharmacology, 2019
Major depressive disorder has become a prominent cause of disability, as lifetime prevalence has increased to ~15% in the Western world. Pharmacological effects of serotonin (5-hydroxytryptamine, 5-HT) are mediated through 5-hydroxytryptamine receptor (5-
Taichi Ochi, Natalya M. Vyalova, Innokentiy S. Losenkov, Diana Z. Paderina, Diana Z. Paderina, Ivan V. Pozhidaev, Ivan V. Pozhidaev, Anton J. M. Loonen, Anton J. M. Loonen, German G. Simutkin, Nikolay A. Bokhan, Nikolay A. Bokhan, Nikolay A. Bokhan, Svetlana A. Ivanova, Svetlana A. Ivanova, Svetlana A. Ivanova, Bob Wilffert, Bob Wilffert   +17 more
doaj   +1 more source

Neuroreceptor imaging in depression

Neurobiology of Disease, 2013
The in vivo study of receptor binding potential in the human brain is made possible by positron emission tomography (PET) imaging. Here we review PET studies of neuroreceptor function in mood disorders — specifically, major depressive disorder (MDD) and ...
Jonathan B. Savitz, Wayne C. Drevets
doaj   +1 more source

Serotonin 5-HT2A and 5-HT2C receptors differentially modulate the acquisition and expression of voluntary alcohol drinking in male mice

Frontiers in Neuroscience
IntroductionStudies suggest that serotonin (5-HT) plays an important role in alcohol use disorder (AUD). While several receptor subtypes modulate the role of 5-HT in AUD, evidence suggests that 5-HT2A and 5-HT2C receptors may be directly involved in ...
Sandy C. Simões, Livia N. Amorim, Yasmim A. Serra, Camila S. Abreu, Maria Clara E. Santana, João P. C. Leite, Carla M. Kaneto, Roberta C. A. Costa, Kaio R. Ferreira, Isabelle C. S. de Oliveira, Alexandre J. Oliveira-Lima, Agnieszka Sulima, Kenner C. Rice, Eduardo A. V. Marinho, Lais F. Berro, Lais F. Berro   +15 more
doaj   +1 more source

5-HT2A Serotonin Receptor Density in Adult Male Rats’ Hippocampus after Morphine-based Conditioned Place Preference

Basic and Clinical Neuroscience, 2016
Introduction: A close interaction exists between the brain opioid and serotonin (5-HT) neurotransmitter systems. Brain neurotransmitter 5-HT plays an important role in the regulation of reward-related processing.
Rabie Mohammadi, Mehrdad Jahanshahi, Seyed Behnamedin Jameie   +2 more
doaj  

Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors

Neuropsychiatric Disease and Treatment, 2018
Michael De Santis,1,2 Xu-Feng Huang,2 Chao Deng1,2 1Antipsychotic Research Laboratory, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia; 2School of Medicine, University of Wollongong, Wollongong, NSW,
De Santis M, Huang XF, Deng C
doaj  

Behavioral Mechanisms That Depend on Dopamine and Serotonin in Interact With the Antipsychotics Risperidone and Aripiprazole

Journal of Experimental Neuroscience, 2018
The neurotransmitters dopamine and serotonin participate in specific behavioral neuromuscular mechanisms in the nematode Caenorhabditis elegans . Dopamine is involved in the gentle touch response and serotonin in the pharyngeal pumping rate.
Jaime Osuna-Luque, Ángel Rodríguez-Ramos, María del Mar Gámez-del-Estal, Manuel Ruiz-Rubio   +3 more
doaj   +1 more source