Results 101 to 110 of about 22,923 (160)

Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player

Frontiers in Molecular Neuroscience, 2014
The classic neurotrophins Nerve Growth Factor (NGF), Brain Derived Neurotrophic Factor (BDNF) and Neurotrophins NT-3 and NT-4 are well known to regulate various aspects of neuronal differentiation, survival and growth.
Rachel eUren, Ann eTurnley
doaj   +1 more source

Trackins (Trk-Targeting Drugs): A Novel Therapy for Different Diseases

Pharmaceuticals
Many routes may lead to the transition from a healthy to a diseased phenotype. However, there are not so many routes to travel in the opposite direction; that is, therapy for different diseases.
George N. Chaldakov, Luigi Aloe, Stanislav G. Yanev, Marco Fiore, Anton B. Tonchev, Manlio Vinciguerra, Nikolai T. Evtimov, Peter Ghenev, Krikor Dikranian   +8 more
doaj   +1 more source

Deletion of p75NTR prevents vaso-obliteration and retinal neovascularization via activation of Trk- A receptor in ischemic retinopathy model

Scientific Reports, 2018
Ischemic retinopathy is characterized by ischemia followed by retinal neovascularization (RNV) resulting in visual impairment. Given the role of neuron-secreted growth factors in regulating angiogenesis, we examined how genetic deletion of the ...
Sally L. Elshaer, Azza B. El-Remessy
doaj   +1 more source

Effects of the selective TrkA agonist gambogic amide on pigmentation and growth of human hair follicles in vitro.

PLoS ONE, 2019
The human hair follicle is a neuroendocrine mini-organ that can be used to study aging processes in vitro. Neurotrophins maintain homeostasis in hair biology via the Trk-family of receptors. TrkA, the high affinity receptor for nerve growth factor (NGF),
Remo Campiche, Maria Daniltchenko, Dominik Imfeld, Eva M J Peters   +3 more
doaj   +1 more source

The Role of Polyubiquitination in Nerve Growth Factor Signaling and its Alteration in Alzheimer’s Disease [PDF]

, 2016
Nerve growth factor (NGF) is a neurotrophin regulates survival and differentiation of neurons. To execute its antiapoptotic function, NGF binds to selective receptor TrkA and non-selective receptor p75NTR, leading to TrkA dimerization and ...
Zheng, Chen
core  

A Spaetzle-like role for Nerve Growth Factor β in vertebrate immunity to Staphylococcus aureus [PDF]

, 2014
Many key components of innate immunity to infection are shared between Drosophila and humans. However, the fly Toll ligand Spaetzle is not thought to have a vertebrate equivalent.
Antrobus, R, Blunde, T, Brown, K, Bryant,, C, Cachat, J, Connolly, J, Floto, R. A., Foster, S.J., Grogono, D. M., Hammond, K.L., Hegyi, K, Hepburn, L, Holden, M, Kaser, A, Klapholz, C, Ligoxygakis, P, Loynes, C, Minichiello, L, Moreno, P, Ny, T, Ochoa, B, Ogryzko, N.V., Otto, M, Peacock, S. J., Prajsnar, T.K., Renshaw, S.A., Schiebler, M, Seneviratne, S. L., Surewaard, B, Török, M. E., Wang, L, Woods, C. G.   +31 more
core  

Binding Selectivity Analysis from Alchemical Receptor Hopping and Swapping Free Energy Calculations [PDF]

arXiv
We present receptor hopping and receptor swapping free energy estimation protocols based on the Alchemical Transfer Method (ATM) to model the binding selectivity of a set of ligands to two arbitrary receptors. The receptor hopping protocol, where a ligand is alchemically transferred from one receptor to another in one simulation, directly yields the ...
arxiv  

A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells. [PDF]

, 2019
Elevated glucose consumption is fundamental to cancer, but selectively targeting this pathway is challenging. We develop a high-throughput assay for measuring glucose consumption and use it to screen non-small-cell lung cancer cell lines against ...
Chen, Bao Ying, Clark, Peter M, Damoiseaux, Robert, Ghezzi, Chiara, Ribalet, Bernard, Wong, Alicia   +5 more
core   +1 more source

TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis. [PDF]

J Clin Invest, 2018
Singh R, Karri D, Shen H, Shao J, Dasgupta S, Huang S, Edwards DP, Ittmann MM, O'Malley BW, Yi P.   +9 more
europepmc   +1 more source

The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF are increased in squamous cell carcinomas of the lung. [PDF]

Sci Rep, 2018
Gao F, Griffin N, Faulkner S, Rowe CW, Williams L, Roselli S, Thorne RF, Ferdoushi A, Jobling P, Walker MM, Hondermarck H.   +10 more
europepmc   +1 more source