Results 31 to 40 of about 2,320,796 (216)
Journal of Neuroscience, 2005 Nerve growth factor (NGF) and its TrkA receptor exert important bioactivities on neuronal cells such as promoting survival and neurite outgrowth. Activated TrkA receptors are not only localized on the cell surface but also in signaling endosomes, and ...
S. Saxena +3 more
semanticscholar +1 more source
ProNGF and Neurodegeneration in Alzheimer’s Disease
Frontiers in Neuroscience, 2019 Profound and early basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of Alzheimer’s disease (AD). Loss of synapses between basal forebrain and hippocampal and cortical target tissue correlates highly with the degree of dementia and is ...
Margaret Fahnestock, Arman Shekari
doaj +1 more source
Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles
Scientific Reports, 2023 Proper wiring of the peripheral nervous system relies on neurotrophic signaling via nerve growth factor (NGF). NGF secreted by target organs (i.e. eye) binds to the TrkA receptor expressed on the distal axons of postganglionic neurons. Upon binding, TrkA
Ashley J. Mason +4 more
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Receptor tyrosine kinase signaling mechanisms: Devolving TrkA responses with phosphoproteomics [PDF]
Advances in Biological Regulation, 2013 Receptor tyrosine kinases (RTKs) function through protein kinase entities located in the intracellular domain of each protomer. Following activation by ligand binding, they selectively form phosphotyrosine residues by autocatalytic modification. Some of these sites are involved in maintaining the active conformation of the kinase, while others become ...
Bradshaw, RA +3 more
openaire +4 more sources
NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish
Scientific Reports, 2017 Expression of neuroendocrine-associated phosphatase (NEAP, also named as dual specificity phosphatase 26, [DUSP26]) is restricted to neuroendocrine tissues. We found that NEAP, but not its phosphatase-defective mutant, suppressed nerve growth factor (NGF)
Chi-Hwa Yang +9 more
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PLoS Pathogens, 2022 Influenza A virus (IAV) infection causes acute respiratory disease with potential severe and deadly complications. Viral pathogenesis is not only due to the direct cytopathic effect of viral infections but also to the exacerbated host inflammatory ...
Vikram Verma +6 more
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Cells, 2022 The Nerve Growth Factor (NGF) belongs to the neurothrophins protein family involved in the survival of neurons in the nervous system. The interaction of NGF with its high-affinity receptor TrkA mediates different cellular pathways related to Alzheimer’s ...
Serena Vittorio +6 more
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TrkA inhibition alleviates bladder overactivity in cyclophosphamide-induced cystitis by targeting hyperpolarization-activated cyclic nucleotide-gated channels [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): To investigate the potential of Tropomyosin receptor kinase A (TrkA) for the treatment of interstitial cystitis/ bladder pain syndrome (IC/BPS).Materials and Methods: Sixty-four female rats were randomly assigned to the control and ...
Qian Liu +4 more
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International Journal of Molecular Sciences, 2022 Tropomyosin receptor kinase A (TrkA/NTRK1) is a high-affinity receptor for nerve growth factor (NGF), a potent pain mediator. NGF/TrkA signaling elevates synovial sensory neuronal distributions in the joints and causes osteoarthritis (OA) pain.
I. O-Sullivan +11 more
semanticscholar +1 more source
Role of NGF/TrkA signaling milieu in depressogenic induction of rat brain [PDF]
Al Ameen Journal of Medical Sciences, 2013 Objectives: Stress-induced helplessness in rodents constitutes a well-defined model to investigate neurobiological mechanism of depression. In the present investigation, we investigated the correlation between stress induced helplessness and NGF, its ...
Ritabrata Banerjee +3 more
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