Results 61 to 70 of about 2,320,796 (216)

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Effects of castration on the expression of the NGF and TrkA in the vas deferens and accessory male genital glands of the rat

European Journal of Histochemistry, 2009
Nerve Growth Factor (NGF) is a member of the neurotrophin family. Neurotrophins exert their effects by binding to corresponding receptors, which are formed by the tyrosine protein kinases TrkA, TrkB, and TrkC, and the low affinity p75NTR receptor.
C. Squillacioti, A. De Luca, S. Paino, E. Langella, N. Mirabella   +4 more
doaj   +3 more sources

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation.

PLoS ONE, 2019
In the brain, the TrkA receptor for Nerve Growth Factor (NGF) is expressed primarily in the cholinergic system. TrkA/NGF support neuronal health and function, and deficiencies in this axis are associated with progressive cholinergic neuron atrophy and ...
Sylvia Josephy-Hernandez, Iulia Pirvulescu, Mario Maira, Tahar Aboulkassim, Tak Pan Wong, R Anne McKinney, H Uri Saragovi   +6 more
doaj   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

A rich network of S100+/tropomyosin receptor kinase A+ nerve fibers in the connective tissue wall of radicular cysts: An immunohistochemical study of biopsy cases

Saudi Endodontic Journal
Introduction: Limited information is available regarding the presence of nerve fibres in human radicular granulomas and cysts. The aim of the present study was to map the neural network of human radicular cysts by the immunohistochemical expression of ...
Nikolaos P. Kerezoudis, Taxiarchis G. Kontogiannis, Konstantinos I. Tosios   +2 more
doaj   +1 more source

Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons [PDF]

Development, 2003
The TrkA/NGF receptor is essential for the survival and differentiation of sensory neurons. The molecular mechanisms regulating tissue and stage-specific expression of TrkA are largely unknown. The Brn3a POU-domain transcription factor has been implicated in the development of the PNS and proposed as a transcription regulator for TrkA.
Long, Ma, Lei, Lei, S Raisa, Eng, Eric, Turner, Luis F, Parada   +4 more
openaire   +2 more sources

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

MedComm, Volume 7, Issue 2, February 2026.
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu, Zhi‐Shan Ge, Qing‐Yue Cao, Zi‐Han Li, An Zhang, Hai‐Dong Zhu, Gao‐Jun Teng   +6 more
wiley   +1 more source

ProteinDJ: A high‐performance and modular protein design pipeline

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Leveraging artificial intelligence and deep learning to generate proteins de novo (a.k.a. ‘synthetic proteins’) has unlocked new frontiers of protein design. Deep learning models trained on protein structures can generate novel protein designs that explore structural landscapes unseen by evolution.
Dylan Silke, Julie Iskander, Junqi Pan, Andrew P. Thompson, Anthony T. Papenfuss, Isabelle S. Lucet, Joshua M. Hardy   +6 more
wiley   +1 more source

TrkA regulates the regenerative capacity of bone marrow stromal stem cells in nerve grafts

Neural Regeneration Research, 2019
We previously demonstrated that overexpression of tropomyosin receptor kinase A (TrkA) promotes the survival and Schwann cell-like differentiation of bone marrow stromal stem cells in nerve grafts, thereby enhancing the regeneration and functional ...
Mei-Ge Zheng, Wen-Yuan Sui, Zhen-Dan He, Yan Liu, Yu-Lin Huang, Shu-Hua Mu, Xin-Zhong Xu, Ji-Sen Zhang, Jun-Le Qu, Jian Zhang, Dong Wang   +10 more
doaj   +1 more source

Ligand signature in the membrane dynamics of single TrkA receptor molecules [PDF]

Journal of Cell Science, 2013
Summary The neurotrophin receptor TrkA (also known as NTRK1) is known to be crucially involved in several physio-pathological processes. However, a clear description of the early steps of ligand-induced TrkA responses at the cell plasma membrane is missing.
Laura Marchetti1, 2, Andrea Callegari1, Stefano Luin1, Giovanni Signore3, Alessandro Viegi2, Fabio Beltram1, 3, Antonino Cattaneo2   +8 more
openaire   +3 more sources