Results 31 to 40 of about 148,079 (360)

Osteoprotegerin and Soluble Receptor Activator of Nuclear Factor-Kappa B Ligand in Exudative Age-Related Macular Degeneration

Acta Medica Iranica, 2014
Calcification and inflammation are among the important cases of exudative age-related macular degeneration (E-ARMD). The aim of the present study was to elucidate if there is any relationship between serum Osteoprotegerin (OPG), soluble receptor ...
Amir Ghorbanihaghjo, Alireza Javadzadeh, Nadereh Rashtchizadeh, Rana Sorkhabi, Hasan Khalili, Babak Rahimi-Ardabili   +5 more
doaj   +2 more sources

Polycomb Repressive Complex 2 Regulates Genes Necessary for Intestinal Microfold Cell (M Cell) Development [PDF]

, 2021
BACKGROUND & AIMS: Microfold cells (M cells) are immunosurveillance epithelial cells located in the Peyer's patches (PPs) in the intestine and are responsible for monitoring and transcytosis of antigens, microorganisms, and pathogens.
George, Joel Johnson, Iqbal, Md Sharif, Kaikkonen, Minna U., Katajisto, Pekka, Martin-Diaz, Laura, Martins, Fabio Tadeu Arrojo, Niskanen, Henri, Oittinen, Mikko, Rintakangas, Terhi Maria Kristiina, Viiri, Keijo, Zapilko, Veronika   +10 more
core   +2 more sources

Dramatic response of aneurysmal bone cyst to denosumab: Case report and literature review

Clinical Case Reports, 2021
Denosumab, a monoclonal antibody that specifically targets cytokine receptor activator of nuclear factor‐kappa B ligand (RANKL), is a potentially viable option in resistant aneurysmal bone cysts.
Pedram Fadavi, Amir Mohammad Arefpour, Ramyar Hariri, Maryam Vasheghani, Maryam Garousi, Farzad Taghizadeh‐Hesary   +5 more
doaj   +1 more source

Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration

BMC Musculoskeletal Disorders, 2019
Background The expression of the receptor activator of nuclear factor kappa B (RANK) /RANK ligand (RANKL) /osteoprotegerin (OPG) system and its association with the progression of intervertebral disc (IVD) degeneration has recently been reported in a ...
Tomohiko Sano, Koji Akeda, Junichi Yamada, Norihiko Takegami, Takao Sudo, Akihiro Sudo   +5 more
doaj   +1 more source

The Skeletal-Protecting Action and Mechanisms of Action for Mood-Stabilizing Drug Lithium Chloride: Current Evidence and Future Potential Research Areas

Frontiers in Pharmacology, 2020
Lithium, the lightest natural-occurring alkali metal with an atomic number of three, stabilizes the mood to prevent episodes of acute manic and depression.
Sok Kuan Wong, Kok-Yong Chin, Kok-Yong Chin, Soelaiman Ima-Nirwana   +3 more
doaj   +1 more source

Effects and mechanisms of natural alkaloids for prevention and treatment of osteoporosis

Frontiers in Pharmacology, 2022
Natural alkaloids are polycyclic, nitrogen-containing, and basic compounds obtained from plants. In this review, the advances in bioactive alkaloids with respect to their chemical structures, herbal sources, and effects for the prevention and treatment ...
Bingfeng Lin, Pingcui Xu, Juan Zheng, Xuehui Deng, Qitao Ye, Zhongping Huang, Nani Wang   +6 more
doaj   +1 more source

High Expression Levels of Receptor Activator of Nuclear Factor‐Kappa B Ligand Associated With Human Chronic Periodontitis Are Mainly Secreted by CD4⁺ T Lymphocytes

The Journal of Periodontology, 2006
Rolando Vernal, Nicolás Dutzan, Marcela Hernández, Sabrita Chandía, Javier Puente, Rubén León, Leyre García, Ignacio del Valle, Augusto Silva, Jorge Gamonal   +9 more
openalex   +3 more sources

Vav1 inhibits RANKL-induced osteoclast differentiation and bone resorption [PDF]

, 2019
Vav1 is a Rho/Rac guanine nucleotide exchange factor primarily expressed in hematopoietic cells. In this study, we investigated the potential role of Vav1 in osteoclast (OC) differentiation by comparing the ability of bone marrow mononuclear cells (BMMCs)
Cha, Young-Nam, Dinauer, Mary C., Jang, Jin Sun, Kang, In Soon, Kim, Chaekyun, Kim, Young-June, Lee, Zang Hee   +6 more
core   +2 more sources

Efficiency of Estrogen Replacement Therapy in Osteoporosis [PDF]

, 2018
Estrogen therapy has been taken as a settled approach for both prevention and treatment of osteoporosis, especially in post-menopausal women as well as for the treatment of symptoms associated with menopause.
Haq, Aatera, Mazhar Uddin, Syed Mohammad, Sheikh, Haris, Yaqoob, Uzair, Zafar Sayeed, Bushra   +4 more
core   +3 more sources

Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease [PDF]

, 2014
Multiple myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM ...
Blum B, Eriksen EF, Klein B, Lipton A, Mundy GR, Schmitt CP, Shay G   +6 more
core   +1 more source