Results 101 to 110 of about 836,416 (221)
Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy
Frontiers in Immunology, 2018 Recent advances in cancer treatment have emerged from new immunotherapies targeting T-cell inhibitory receptors, including cytotoxic T-lymphocyte associated antigen (CTLA)-4 and programmed cell death (PD)-1.
A. Durgeau +3 more
semanticscholar +1 more source
Molecular Therapy: Oncolytics, 2016 Chimeric antigen receptors (CARs) are synthetic receptors that usually redirect T cells to surface antigens independent of human leukocyte antigen (HLA).
Marcela V Maus +8 more
doaj +1 more source
DapPep: Domain Adaptive Peptide-agnostic Learning for Universal T-cell Receptor-antigen Binding Affinity Prediction [PDF]
arXivIdentifying T-cell receptors (TCRs) that interact with antigenic peptides provides the technical basis for developing vaccines and immunotherapies. The emergent deep learning methods excel at learning antigen binding patterns from known TCRs but struggle with novel or sparsely represented antigens.
arxiv
An Introduction to Rule-based Modeling of Immune Receptor Signaling [PDF]
arXiv, 2017 Cells process external and internal signals through chemical interactions. Cells that constitute the immune system (e.g., antigen presenting cell, T-cell, B-cell, mast cell) can have different functions (e.g., adaptive memory, inflammatory response) depending on the type and number of receptor molecules on the cell surface and the specific ...
arxiv
Inflammation and RegenerationIn recent years, immunotherapy has become a standard cancer therapy, joining surgery, chemotherapy, and radiation therapy. This therapeutic approach involves the use of patient-derived antigen-specific T cells or genetically modified T cells engineered ...
Sota Kurihara +2 more
doaj +1 more source
Population dynamics of immune repertoires [PDF]
arXiv, 2017 The evolution of the adaptive immune system is characterized by changes in the relative abundances of the B- and T-cell clones that make up its repertoires. To fully capture this evolution, we need to describe the complex dynamics of the response to pathogenic and self-antigenic stimulations, as well as the statistics of novel lymphocyte receptors ...
arxiv
T‐cell antigen receptor signal transduction
Immunology, 2002 T-cell activation by foreign antigen induces antigen specific T-cell clonal expansion and differentiation and this response is regulated by signal transduction pathways initiated by antigen receptors and costimulatory molecules. The stimulus that drives T-cell activation is a foreign peptide bound to major histocompatibility complex (MHC)-encoded ...
openaire +4 more sources
Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses
Cell, 2018 J. Cho, J. Collins, W. Wong
semanticscholar +1 more source
A unified cross-attention model for predicting antigen binding specificity to both HLA and TCR molecules [PDF]
arXivThe immune checkpoint inhibitors have demonstrated promising clinical efficacy across various tumor types, yet the percentage of patients who benefit from them remains low. The bindings between tumor antigens and HLA-I/TCR molecules determine the antigen presentation and T-cell activation, thereby playing an important role in the immunotherapy response.
arxiv
Engineering and Design of Chimeric Antigen Receptors
Molecular Therapy: Methods & Clinical Development, 2019 T cells engineered with chimeric antigen receptors (CARs) have emerged as a potent new class of therapeutics for cancer, based on their remarkable potency in blood cancers.
Sonia Guedan +3 more
doaj