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The gamma T-cell antigen receptor
Journal of Clinical Immunology, 1987The gamma-TCR is encoded by genes composed of V, J, and C elements that demonstrate a limited potential for recombinational diversity. These genes are rearranged, transcribed, and translated into proteins early during thymic ontogeny. Lymphocytes express gamma-TCR proteins on the plasma membrane only in association with the CD3 complex.
Joseph H. Phillips +7 more
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Antigen Receptors of T Helper Cells
1977The function of the immune system is based on a large variety of receptor molecules that differ in their binding specificity. These receptors are located in part on the surfaces of the immunocompetent cells, namely, T and B lymphocytes, and in part appear free in the circulation.
Klaus Rajewsky, Klaus Eichmann
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The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition
Annual Review of Immunology, 1986The genes encoding the alpha and beta chain of the T-cell receptor and the gamma gene have been cloned, and their structure, organization, ontogeny of expression, pattern of rearrangement, and diversification are now generally understood. In most cases, the immunoglobulin paradigm applied very well to the corresponding phenomena in T cells, although as
Leroy Hood +3 more
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Antigen-specific T cell receptors
1987Publisher Summary This chapter discusses immunoglobulin-related T cell receptors. It also presents the production of antibodies to both antigen-binding T cell receptors that are known to be related to immunoglobulin variable regions and to the α/β heterodimers that do not bind antigen, but are encoded by rearranged genes showing sufficient homology ...
John J. Marchalonis, Samuel F. Schluter
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T cell antigen receptor antibodies
Nature, 1987Immunology has a long tradition of using the immune system to study the immune system. Monoclonal antibodies are now being focused upon the antigen receptor of the T lymphocyte.
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Current Opinion in Immunology, 1994
Antigen receptors have a dual role on the surface of B lymphocytes, namely the binding and internalization of antigens and the activation of the antigen-recognizing B cell. The structural requirements for internalization are still a matter of controversy; but as far as signalling is concerned it is becoming increasingly apparent that the antigen ...
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Antigen receptors have a dual role on the surface of B lymphocytes, namely the binding and internalization of antigens and the activation of the antigen-recognizing B cell. The structural requirements for internalization are still a matter of controversy; but as far as signalling is concerned it is becoming increasingly apparent that the antigen ...
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T cell antigen receptors in autoimmunity.
The Journal of Immunology, 1988Abstract Three mAb to variable region determinants of the alpha/beta-chain TCR were used to detect discrete populations of peripheral blood T cells. T cells sharing a TCR determinant defined by such an antibody presumably use the same or similar TCR V or J genes for their alpha- or beta-chains.
D N, Posnett +8 more
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Antigen receptors and dendritic cells
Vaccine, 2000Several age-related alterations occurring in the immune system, especially in T cells and in B cells, may account for an increased susceptibility to infections, autoimmune diseases, and malignancies. In particular, the adaptive immune response has been shown to lose part of its diversity and its memory in old mice.
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Specificity of the T Cell Receptor for Antigen
1988Publisher Summary This chapter discusses the evolutionary and organismal influences of the specificity of the T cell receptor that may have contributed to a particular strategy of immune recognition. Understanding the specificity of recognition in the immune system is uniquely complicated because of the vast diversity of the specific receptors.
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T-cell antigen receptors in rheumatoid arthritis
Immunologic Research, 1994Rheumatoid arthritis (RA) is a systemic disease of unknown etiology characterized by chronic inflammation mainly in the joints. Several lines of evidence suggest that T cells are involved in the pathogenesis of the disease. RA is associated with certain HLA-DR alleles.
Chris D. Platsoucas +2 more
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