Results 81 to 90 of about 836,416 (221)

Developing T-cell therapies for lymphoma without receptor engineering

Blood Advances, 2017
: T-cell therapy has emerged from the bench for the treatment of patients with lymphoma. Responses to T-cell therapeutics are regulated by multiple factors, including the patient's immune system status and disease stage.
Melanie Grant, Catherine M. Bollard
doaj  

Prospects for γδ T cells and chimeric antigen receptor γδ T cells in cancer immunotherapy

Frontiers in Immunology
γδ T cells, a type of specialized T cell, differ from alpha-beta T cells due to the presence of γ and δ chain surface T cell receptors. These receptors allow them to directly recognize and bind antigenic molecules without the requirement of attachment to
Lu Wang, Jiaqi Li, Yaping Xuan, Jinrui Zhang, Xiao Wang, Wei Hu, Wei Hu, Wei Hu, Lei Xiu   +8 more
doaj   +1 more source

Molecular Design, Optimization, and Genomic Integration of Chimeric B Cell Receptors in Murine B Cells

Frontiers in Immunology, 2019
Immune cell therapies based on the integration of synthetic antigen receptors comprise a powerful strategy for the treatment of diverse diseases, most notably T cells engineered to express chimeric antigen receptors (CAR) for targeted cancer therapy.
Theresa Pesch, Lucia Bonati, William Kelton, Cristina Parola, Cristina Parola, Roy A. Ehling, Lucia Csepregi, Lucia Csepregi, Daisuke Kitamura, Sai T. Reddy   +9 more
doaj   +1 more source

A mathematical model of the effects of aging on naive T-cell population and diversity [PDF]

arXiv, 2019
The human adaptive immune response is known to weaken in advanced age, resulting in increased severity of pathogen-born illness, poor vaccine efficacy, and a higher prevalence of cancer in the elderly. Age-related erosion of the T-cell compartment has been implicated as a likely cause, but the underlying mechanisms driving this immunosenescence have ...
arxiv  

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

Science Translational Medicine, 2011
Adoptively transferred gene-modified T cells expand in vivo, eliminate leukemic cells, and form functional memory cells in patients. Go CAR-Ts in the Fast Lane As members of the body’s police force, cells of the immune system vigilantly pursue bad actors
M. Kalos, B. Levine, D. Porter, Sharyn I. Katz, S. Grupp, A. Bagg, C. June   +6 more
semanticscholar   +1 more source

Limits on Inferring T-cell Specificity from Partial Information [PDF]

A key challenge in molecular biology is to decipher the mapping of protein sequence to function. To perform this mapping requires the identification of sequence features most informative about function. Here, we quantify the amount of information (in bits) that T-cell receptor (TCR) sequence features provide about antigen specificity.
arxiv   +1 more source

Model for Diversity Analysis of Antigen Receptor Repertoires [PDF]

arXiv, 2010
In most of the recent immunological literature the differences across antigen receptor populations are examined via non-parametric statistical measures of species overlap and diversity borrowed from ecological studies. While this approach is robust in a wide range of situations, it seems to provide little insight into the underlying clonal size ...
arxiv  

Nr4a transcription factors limit CAR T cell function in solid tumors

Nature, 2019
T cells expressing chimeric antigen receptors (CAR T cells) targeting human CD19 (hCD19) have shown clinical efficacy against B cell malignancies1,2.
Joyce Chen, Isaac F. López-Moyado, Hyungseok Seo, C. Lio, Laura J. Hempleman, T. Sekiya, A. Yoshimura, J. Scott-Browne, A. Rao   +8 more
semanticscholar   +1 more source

Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases

Journal of Immunology Research, 2019
Chimeric antigen receptor T (CAR-T) cells are T cells engineered to express specific synthetic antigen receptors that can recognize antigens expressed by tumor cells, which after the binding of these antigens to the receptors are eliminated, and have ...
Yuehong Chen, Jianhong Sun, Huan Liu, Geng Yin, Qibing Xie   +4 more
doaj   +1 more source

T Cells Genetically Modified to Express an Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor Cause Remissions of Poor-Prognosis Relapsed Multiple Myeloma.

Journal of Clinical Oncology, 2018
Purpose Therapies with novel mechanisms of action are needed for multiple myeloma (MM). T cells can be genetically modified to express chimeric antigen receptors (CARs), which are artificial proteins that target T cells to antigens.
Jennifer N. Brudno, I. Maric, Steven D Hartman, J. Rose, Michael L. Wang, Norris Lam, M. Stetler-Stevenson, Dalia A. Salem, C. Yuan, S. Pavletic, J. Kanakry, S. A. Ali, Lekha Mikkilineni, S. Feldman, D. Stroncek, B. Hansen, Judith Lawrence, Rashmika Patel, F. Hakim, R. Gress, J. Kochenderfer   +20 more
semanticscholar   +1 more source