Pathogenesis of Vitiligo: Integrating Immune and Non‐Immune Cell Crosstalk
ABSTRACT Vitiligo is an acquired autoimmune disease characterized by depigmented macules resulting from melanocyte loss. It is a complex multifactorial disorder in which genetic predisposition is combined with environmental factors; however, its detailed etiology remains unclear.
Shintaro Inoue
wiley +1 more source
Activation of the Ahr-IL-6 Axis by Kynurenic Acid Promotes Bone Marrow-Derived MSC Expansion. [PDF]
Nguyen CH +6 more
europepmc +1 more source
Host Oxidative Response Capacity Determines Longevity Outcomes of Microbial Interventions
Genetic variation determines whether microbial interactions extend or shorten host lifespan via redox homeostasis. This discovery highlights the critical role of host genetics in shaping microbiota‐driven aging, offering a new framework for precision microbiome interventions tailored to individual needs for promoting longevity.
Xusheng Hao +8 more
wiley +1 more source
Intestinal amino acid metabolic response and its roles in inflammatory bowel disease. [PDF]
Niu Y, Wang F, Liu C, Liu Z, Hu X.
europepmc +1 more source
The Effect of Ecopipam on the Pharmacokinetics of Concomitant Medications
ABSTRACT Ecopipam is a first‐in‐class dopamine D1 receptor antagonist under investigation for the treatment of Tourette syndrome. This open‐label, fixed‐sequence, three‐cohort study evaluated whether ecopipam induces or inhibits cytochrome P450 (CYP) 1A2, CYP2B6, CYP2C19, CYP2D6, CYP3A4, organic anion‐transporting polypeptide (OATP) 1B1, and p ...
Virginia D. Schmith +4 more
wiley +1 more source
Identification and validation of aryl hydrocarbon receptor-associated hub genes in ulcerative colitis via integrated bioinformatics analysis. [PDF]
Zhao Y +8 more
europepmc +1 more source
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Greece, and co‐rapporteur Member State, France, for the pesticide active substance paraffin oil (CAS 72623‐86‐0) are reported.
European Food Safety Authority (EFSA) +48 more
wiley +1 more source
The Aryl Hydrocarbon Receptor Mediates the Neurodevelopmental Toxicity of Perfluorooctane Sulfonamide in Zebrafish Larvae. [PDF]
Chen P +4 more
europepmc +1 more source
The absence or the pharmacological blockade of the aryl hydrocarbon receptor promotes neuroprotection in the hippocampus after an ischemic insult. [PDF]
Castañeda-Arellano R +8 more
europepmc +1 more source

