Activation of Calcitonin Receptor and Calcitonin Receptor-like Receptor by Membrane-anchored Ligands [PDF]
Journal of Biological Chemistry, 2010 G protein-coupled receptors (GPCRs) are the most important pharmaceutical targets, and more than 40% of drugs in use today modulate GPCR signaling. A major hurdle in the development of therapies targeting GPCRs is the drug candidate's nonselective actions in multiple tissues.
Chia Lin, Chang +2 more
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Biomedicines, 2023 Medullary thyroid cancer originates from parafollicular C-cells in the thyroid. Despite successful thyroidectomy, localizing remnant cancer cells in patients with elevated calcitonin and carcinoembryonic antigen levels remains a challenge.
Hyeon Jeong Lee +9 more
doaj +1 more source
The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]
, 2013 The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Alex C. Conner +13 more
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Solubilization of functional calcitonin receptors [PDF]
Biochemical Journal, 1988 Calcitonin (CT) binding activity has been extracted from a membrane fraction of human placenta using the zwitterionic detergent, 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulphonic acid (Chaps). Approximately two-thirds of the available binding sites were extracted using 5 mM-Chaps. The binding characteristics of 125I-labelled salmon CT(125I-sCT)
Nicholson, G.C. +5 more
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Salmon Calcitonin Exerts an Antidepressant Effect by Activating Amylin Receptors
Frontiers in Pharmacology, 2022 Depressive disorder is defined as a psychiatric disease characterized by the core symptoms of anhedonia and learned helplessness. Currently, the treatment of depression still calls for medications with high effectiveness, rapid action, and few side ...
Jian Jiang +19 more
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The neuropeptide transcriptome of a model echinoderm, the sea urchin Strongylocentrotus purpuratus [PDF]
, 2012 The work reported here was supported by a grant from the University of London Central Research ...
Elphick, MR, Rowe, ML
core +1 more source
Calcitonin receptor-like receptor is expressed on gastrointestinal immune cells [PDF]
, 2002 Background/Aims: Pharmacological and morphological studies suggest that the gut mucosal immune system and local neuropeptide-containing neurones interact.
Göke, B. +5 more
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Calcitonin and calcitonin receptor‐like receptors: common themes with family B GPCRs? [PDF]
British Journal of Pharmacology, 2012 The calcitonin receptor (CTR) and calcitonin receptor‐like receptor (CLR) are two of the 15 human family B (or Secretin‐like) GPCRs. CTR and CLR are of considerable biological interest as their pharmacology is moulded by interactions with receptor activity‐modifying proteins.
Barwell, James +5 more
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Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations
International Journal of Endocrinology, 2020 Calcitonin was discovered as a peptide hormone that was known to reduce the calcium levels in the systemic circulation. This hypocalcemic effect is produced due to multiple reasons such as inhibition of bone resorption or suppression of calcium release ...
Jingbo Xie +9 more
doaj +1 more source
Triptans and CGRP blockade - impact on the cranial vasculature [PDF]
, 2017 The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including serotonin and calcitonin gene-related peptide ...
Alejandro Labastida-Ramírez +9 more
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